LOCUS NC_001735 53423 bp DNA circular CON 26-AUG-2013 DEFINITION Enterobacter aerogenes plasmid R751, complete sequence. ACCESSION NC_001735 VERSION NC_001735.4 GI:113911681 DBLINK Project: 187842 BioProject: PRJNA187842 KEYWORDS RefSeq. SOURCE Enterobacter aerogenes ORGANISM Enterobacter aerogenes Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Enterobacter. REFERENCE 1 (bases 1 to 53423) AUTHORS Thorsted,P.B., Macartney,D.P., Akhtar,P., Haines,A.S., Ali,N., Davidson,P., Stafford,T., Pocklington,M.J., Pansegrau,W., Wilkins,B.M., Lanka,E. and Thomas,C.M. TITLE Complete sequence of the IncPbeta plasmid R751: implications for evolution and organisation of the IncP backbone JOURNAL J. Mol. Biol. 282 (5), 969-990 (1998) PUBMED 9753548 REFERENCE 2 (bases 15169 to 18580) AUTHORS Thorsted,P.B., Shah,D.S., Macartney,D., Kostelidou,K. and Thomas,C.M. TITLE Conservation of the genetic switch between replication and transfer genes of IncP plasmids but divergence of the replication functions which are major host-range determinants JOURNAL Plasmid 36 (2), 95-111 (1996) PUBMED 8954881 REFERENCE 3 (bases 4371 to 9118) AUTHORS Thomas,C.M., Smith,C.A., Ibbotson,J.P., Johnston,L. and Wang,N. TITLE Evolution of the korA-oriV segment of promiscuous IncP plasmids JOURNAL Microbiology 141 (Pt 5), 1201-1210 (1995) PUBMED 7773415 REFERENCE 4 (bases 14730 to 15330) AUTHORS Smith,C.A., Pinkney,M., Guiney,D.G. and Thomas,C.M. TITLE The ancestral IncP replication system consisted of contiguous oriV and trfA segments as deduced from a comparison of the nucleotide sequences of diverse IncP plasmids JOURNAL J. Gen. Microbiol. 139 (Pt 8), 1761-1766 (1993) PUBMED 8409919 REFERENCE 5 (bases 10032 to 10181) AUTHORS Smith,C.A. and Thomas,C.M. TITLE Comparison of the organisation of the genomes of phenotypically diverse plasmids of incompatibility group P: members of the IncP beta sub-group are closely related JOURNAL Mol. Gen. Genet. 206 (3), 419-427 (1987) PUBMED 3035342 REFERENCE 6 (bases 9180 to 10049) AUTHORS Smith,C.A. and Thomas,C.M. TITLE Comparison of the nucleotide sequences of the vegetative replication origins of broad host range IncP plasmids R751 and RK2 reveals conserved features of probable functional importance JOURNAL Nucleic Acids Res. 13 (2), 557-572 (1985) PUBMED 4000925 REFERENCE 7 (bases 10032 to 14729) AUTHORS Davidson,P. and Thomas,C.M. TITLE Evolutionary relationships of a cryptic transposon, Tn4321, from the IncPbeta plasmid R751 JOURNAL Unpublished REFERENCE 8 (bases 71 to 4844) AUTHORS Macartney,D.P., Williams,D.R., Stafford,T., Foster,A. and Thomas,C.M. TITLE Evolution of the partitioning and global regulation functions of the IncP central control region JOURNAL Unpublished REFERENCE 9 (bases 1 to 53423) AUTHORS Haines,A.S. and Thomas,C.M. TITLE Direct Submission JOURNAL Submitted (15-JUL-2005) School of Biological Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK REMARK Sequence update by submitter REFERENCE 10 (bases 1 to 53423) AUTHORS Haines,A.S., Cheung,M. and Thomas,C.M. TITLE Direct Submission JOURNAL Submitted (19-APR-2005) School of Biological Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK REMARK Sequence update by submitter REFERENCE 11 (bases 1 to 53423) AUTHORS Haines,A.S. and Thomas,C.M. TITLE Direct Submission JOURNAL Submitted (30-JUL-2001) School of Biological Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK REMARK Sequence update by submitter REFERENCE 12 (bases 1 to 53423) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (24-OCT-2000) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 13 (bases 1 to 53423) AUTHORS Thomas,C.M. TITLE Direct Submission JOURNAL Submitted (19-AUG-1996) School of Biological Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U67194. On Sep 1, 2006 this sequence version replaced gi:62765883. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..53423 /organism="Enterobacter aerogenes" /mol_type="genomic DNA" /db_xref="taxon:548" /plasmid="R751" /note="broad host range; IncP plasmid" terminator 135..167 /note="bidirectional transcriptional terminator" gene complement(166..832) /gene="upf54.4" /locus_tag="R751p01" /db_xref="GeneID:877465" CDS complement(166..819) /gene="upf54.4" /locus_tag="R751p01" /function="unknown" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044213.1" /db_xref="GI:10955184" /db_xref="GeneID:877465" /translation="MKRLTIPGSGTESRATKPARVSAPATLGGAAFGASREDTGADLL EAAQAAEIEQQATLEAAPVEQSYPETLALYVQARARPGGHIEDRLENLIDRQQARLQQ TQASAPGRLSLPGSKRAWQNQQAQQQARLQTLHARLEAVREIKEGMGLHSPKIEELAT RKMRAENPELASDWDAMREAARRHELLMRKQEQERKQSQAQERPGRSQSLGLSARPA" RBS complement(827..832) /gene="upf54.4" /locus_tag="R751p01" gene complement(848..1369) /gene="upf54.8" /locus_tag="R751p02" /db_xref="GeneID:877476" CDS complement(848..1195) /gene="upf54.8" /locus_tag="R751p02" /function="unknown" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044214.1" /db_xref="GI:10955185" /db_xref="GeneID:877476" /translation="MKQRLLVMNGQRIVQAEKDGAWTNQKVDKAGALKPGIYNLYTAQ AADKKQTHAGVIVHADATNVYQQIGKNFVMHARSDFDKVPEIGSAKSISYNAQGKAAV AAEAPKLTRGRSM" RBS complement(1211..1215) /gene="upf54.8" /locus_tag="R751p02" terminator complement(1264..1295) /gene="upf54.8" /locus_tag="R751p02" -10_signal complement(1342..1347) /gene="upf54.8" /locus_tag="R751p02" -35_signal complement(1364..1369) /gene="upf54.8" /locus_tag="R751p02" gene complement(1366..2461) /gene="kfrA" /locus_tag="R751p03" /db_xref="GeneID:877477" CDS complement(1366..2394) /gene="kfrA" /locus_tag="R751p03" /function="regulation of krfA transcription" /note="the bulk of KfrA is predicted to be largely alpha helical and shows numerous potential heptad repeat structures" /codon_start=1 /transl_table=11 /product="KfrA" /protein_id="NP_044215.1" /db_xref="GI:10955186" /db_xref="GeneID:877477" /translation="MAISKEQIFAVADELDAAGQNPTLANVRKQLGSGSFTTISEAMN EWRARKASQAAPIREPAPQAITDKLAELGGDLWAVALEMANNRLAAEREALEAVRQET EAARQEAAELADQLTGELDEAKARVAALEAVEAAAKGEADELRGKLAATSERAATAEA RAGELRTELDHAHQEARQARAERDKAQERATASADQVEALRADLAAANSRTAEIERRA GELRADLERANQATDQARAAQAEQRKAEVAAAERDQVRAELVKVQAKAEAAEQAHQEQ RKAMAAEAHRQAERLTAAQGERDQAKRDAAQAREEAAGLRGRLEALETVMAQGRAADP TSGGRKKT" misc_feature complement(<2146..2388) /gene="kfrA" /locus_tag="R751p03" /note="Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740" /db_xref="CDD:221198" RBS complement(2401..2405) /gene="kfrA" /locus_tag="R751p03" protein_bind 2414..2455 /note="putative KrfA operator on the basis of analogy to plasmid RK2/RP4 (GenBank Accession Number L27758) in which this gene autoregulates its own operon by binding to an operator overlapping the -10 region; KfrA of RK2 and R751 have diverged sufficiently to lose DNA recognition identity but the KfrA promoter is also regulated by KfrA in R751 and the most obvious candidate is this extended inverted repeat" /bound_moiety="KrfA" -10_signal complement(2433..2438) /gene="kfrA" /locus_tag="R751p03" -35_signal complement(2456..2461) /gene="kfrA" /locus_tag="R751p03" protein_bind 2465..2476 /bound_moiety="KorA" protein_bind 2480..2494 /bound_moiety="KorB" gene complement(2574..3635) /gene="korB" /locus_tag="R751p04" /db_xref="GeneID:877478" CDS complement(2574..3623) /gene="korB" /locus_tag="R751p04" /function="regulation of gene expression" /codon_start=1 /transl_table=11 /product="KorB" /protein_id="NP_044216.1" /db_xref="GI:10955187" /db_xref="GeneID:877478" /translation="MSAKTNAKKKEQDKPQSSGLGLDGLGDLAGLLNEQPAANAGGAG PQELPLDLIDEDPHQPRTADNPGFSPESIAEIGETIKARGVKSPISVRENPDAPGRYL INHGARRYRGSKWAHKTTIPAFIDNDYNEADQVIENLQRNELTAREIADFIGRELAKG KKKGEIAKEIGKSPAFVTQHVTLLDLPEPIAEAFNSGRGKDVTVINELVTAYKKNPDE VAAWLADDSQELTRGSVKLLREFLEDKRSHDDGDRDPNTVDALTGKTDAEAGDGEQGP QDDDAKGKKEPKEADPDKLKKAIIQVKHDDRPARLILNRRPPAEGWAWLKYEDDGQEF EADLGTVQLVALLEG" misc_feature complement(2952..3503) /gene="korB" /locus_tag="R751p04" /note="ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180" /db_xref="CDD:232860" misc_feature complement(3207..3485) /gene="korB" /locus_tag="R751p04" /note="ParB-like nuclease domain; Region: ParBc; pfam02195" /db_xref="CDD:251149" misc_feature complement(2880..3152) /gene="korB" /locus_tag="R751p04" /note="KorB domain; Region: KorB; pfam08535" /db_xref="CDD:254862" misc_feature complement(2577..2756) /gene="korB" /locus_tag="R751p04" /note="KorB C-terminal beta-barrel domain; Region: KorB_C; pfam06613" /db_xref="CDD:115283" misc_feature 3091..3153 /note="encodes a region which is predicted to form an alpha helix-turn-alpha helix structure responsible for binding to KorB operator in DNA" gene complement(3620..4704) /gene="incC1" /locus_tag="R751p05" /db_xref="GeneID:877479" CDS complement(3620..4696) /gene="incC1" /locus_tag="R751p05" /function="plasmid partitioning" /codon_start=1 /transl_table=11 /product="IncC1" /protein_id="NP_044217.1" /db_xref="GI:10955189" /db_xref="GeneID:877479" /translation="MGAIHEETANRSPIPDGHQGAGDRAADHRHSARRAGRWPAPGGV CHFAGADQGGGVAGGQSRMGSSRGTAPRGLRASDGGTAGASSVHRQEVGSRRQEETGT QVMKTLVTAIQKGGQGKTFATCHLAFDFLERGLRVAVIDLDTQGNASFTLSAYQSGYL ASQLFTGDTDDLRYWFGKREGESLALIAADANLANLDKMELSQAAAALRASVAALGEF FDVCLIDTAPSLGVAMTAAVLTADYMLSPIEMEAYSLQGMKKMVAVISNLRKQNPKLR FLGMVPNKVDARKPRHVNNLATLQQAYPQLILPFSIGARDSIAEALGEQMPVWKIKKT AARKATQEVRALADYVFTKMEIAQ" misc_feature complement(3848..4378) /gene="incC1" /locus_tag="R751p05" /note="ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042" /db_xref="CDD:238997" misc_feature complement(3737..4375) /gene="incC1" /locus_tag="R751p05" /note="CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656" /db_xref="CDD:250775" misc_feature complement(4337..4357) /gene="incC1" /locus_tag="R751p05" /note="P-loop; other site" /db_xref="CDD:238997" misc_feature complement(order(4022..4024,4337..4339)) /gene="incC1" /locus_tag="R751p05" /note="Magnesium ion binding site [ion binding]; other site" /db_xref="CDD:238997" gene complement(3620..4397) /gene="incC2" /locus_tag="R751p06" /db_xref="GeneID:877487" CDS complement(3620..4384) /gene="incC2" /locus_tag="R751p06" /function="plasmid partitioning" /codon_start=1 /transl_table=11 /product="IncC2" /protein_id="NP_044218.1" /db_xref="GI:10955188" /db_xref="GeneID:877487" /translation="MKTLVTAIQKGGQGKTFATCHLAFDFLERGLRVAVIDLDTQGNA SFTLSAYQSGYLASQLFTGDTDDLRYWFGKREGESLALIAADANLANLDKMELSQAAA ALRASVAALGEFFDVCLIDTAPSLGVAMTAAVLTADYMLSPIEMEAYSLQGMKKMVAV ISNLRKQNPKLRFLGMVPNKVDARKPRHVNNLATLQQAYPQLILPFSIGARDSIAEAL GEQMPVWKIKKTAARKATQEVRALADYVFTKMEIAQ" misc_feature complement(3848..4378) /gene="incC2" /locus_tag="R751p06" /note="ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042" /db_xref="CDD:238997" misc_feature complement(3737..4375) /gene="incC2" /locus_tag="R751p06" /note="CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656" /db_xref="CDD:250775" misc_feature complement(4337..4357) /gene="incC2" /locus_tag="R751p06" /note="P-loop; other site" /db_xref="CDD:238997" misc_feature complement(order(4022..4024,4337..4339)) /gene="incC2" /locus_tag="R751p06" /note="Magnesium ion binding site [ion binding]; other site" /db_xref="CDD:238997" RBS complement(3632..3635) /gene="korB" /locus_tag="R751p04" misc_feature 3648..3665 /note="encodes an ATP binding motif" misc_feature 3960..3977 /gene="incC1" /locus_tag="R751p05" /note="encodes an ATP binding motif" gene complement(4381..4784) /gene="korA" /locus_tag="R751p07" /db_xref="GeneID:877480" CDS complement(4381..4683) /gene="korA" /locus_tag="R751p07" /function="regulation of gene expression" /codon_start=1 /transl_table=11 /product="KorA" /protein_id="NP_044219.1" /db_xref="GI:10955190" /db_xref="GeneID:877480" /translation="MKKRLTEAQFQTAIKGLEIGQQTIDIARGVLVDGRPQAEFVTSL GLTKGAVSQAVSRVWAAAGEQLPEGFERVTAVLPEHQAFIVKKWEADAKRKQEPKS" misc_feature complement(4399..>4506) /gene="korA" /locus_tag="R751p07" /note="conjugal transfer protein TrbA; Provisional; Region: PRK13890" /db_xref="CDD:237547" RBS complement(4394..4397) /gene="incC2" /locus_tag="R751p06" misc_feature 4490..4534 /note="the encoded sequence is predicted to form an alpha helix-turn-helix motif responsible for binding to the KorA operator in DNA; mutational data is available to support this" misc_feature 4577..4681 /note="encodes a region which is similar to Escherichia coli plasmid RK2 TrbB protein encoded by GenBank Accession Number X03962" RBS complement(4690..4693) /gene="korA" /locus_tag="R751p07" RBS complement(4701..4704) /gene="incC1" /locus_tag="R751p05" misc_feature 4748 /note="transcription start point" protein_bind 4756..4768 /bound_moiety="KorA" -10_signal complement(4756..4761) /gene="korA" /locus_tag="R751p07" -35_signal complement(4779..4784) /gene="korA" /locus_tag="R751p07" protein_bind 4788..4803 /bound_moiety="KorB" gene complement(4790..5064) /gene="kleG" /locus_tag="R751p08" /db_xref="GeneID:877481" CDS complement(4790..5053) /gene="kleG" /locus_tag="R751p08" /function="unknown" /codon_start=1 /transl_table=11 /product="KleG" /protein_id="NP_044220.2" /db_xref="GI:15029579" /db_xref="GeneID:877481" /translation="MRHSSLTPRGKSWPCSAPPWPSSRTGWACLPRRCASRRRWRAGR PCSTTRTGPRFARARWIPTTGDRRGRRPQRHRPSTRREQIFSR" gene complement(4797..5338) /gene="kleF" /locus_tag="R751p09" /db_xref="GeneID:877486" CDS complement(4797..5327) /gene="kleF" /locus_tag="R751p09" /function="plasmid maintenance" /codon_start=1 /transl_table=11 /product="KleF" /protein_id="NP_044221.2" /db_xref="GI:15029580" /db_xref="GeneID:877486" /translation="MAKQTLPYPPGFVEPTTGRVAVMVREYADSDLNGDAPAYWYSAQ SEEWGLDPWRLVEGVDPHVGGGSFDVCFASGGTRTVGPLMTFFLSAAHAAQLIDAKGE ELALQRATLAVIADGLGLPAKALRIEAKVEGRPAVFYDQDGATLCACAVDSDHWRQAR ATAATASAIDKARTNF" misc_feature complement(5022..5309) /gene="kleF" /locus_tag="R751p09" /note="Protein of unknown function (DUF2761); Region: DUF2761; pfam10959" /db_xref="CDD:151406" RBS complement(5060..5064) /gene="kleG" /locus_tag="R751p08" gene complement(5329..5671) /gene="kleE" /locus_tag="R751p10" /db_xref="GeneID:877484" CDS complement(5329..5658) /gene="kleE" /locus_tag="R751p10" /function="plasmid maintenance" /codon_start=1 /transl_table=11 /product="KleE" /protein_id="NP_044222.2" /db_xref="GI:15029581" /db_xref="GeneID:877484" /translation="MSNIVKFPRASKPPAPEPVQPAAPAAAPAAPKAEGRGLVAGLVK FVWVATVLVWPVLKWVLAIITFFQFVRMLYHWNTPGVYAGWSFLAYFAALTAITYFVS IYKPKGL" RBS complement(5335..5338) /gene="kleE" /locus_tag="R751p10" RBS complement(5667..5671) /gene="kleE" /locus_tag="R751p10" repeat_region 5744..5765 /rpt_type=inverted gene complement(5803..6032) /gene="kleB" /locus_tag="R751p11" /db_xref="GeneID:877483" CDS complement(5803..6018) /gene="kleB" /locus_tag="R751p11" /function="plasmid maintenance" /codon_start=1 /transl_table=11 /product="KleB" /protein_id="NP_044223.1" /db_xref="GI:10955194" /db_xref="GeneID:877483" /translation="MSKGKIEIIETCCRRCGKSIRTLSHTIIGADDAREKFGSICGGC ITPEEDNELTEMLLAAAVRRMSGATLQ" misc_feature complement(5839..6018) /gene="kleB" /locus_tag="R751p11" /note="Protein of unknown function (DUF2688); Region: DUF2688; pfam10892" /db_xref="CDD:151340" RBS complement(6028..6032) /gene="kleB" /locus_tag="R751p11" repeat_region 6049..6068 /rpt_type=inverted gene complement(6077..6394) /gene="kleA" /locus_tag="R751p12" /db_xref="GeneID:877485" CDS complement(6077..6313) /gene="kleA" /locus_tag="R751p12" /function="plasmid maintenance" /codon_start=1 /transl_table=11 /product="KleA" /protein_id="NP_044224.1" /db_xref="GI:10955195" /db_xref="GeneID:877485" /translation="MSKNKIMPWVDALPNVEATDFQARRDQIEATMAEAAELVKQAEE LRGKAYFAALSLEASAKGEWSSQAVEQAKRSVGW" misc_feature complement(<6182..>6310) /gene="kleA" /locus_tag="R751p12" /note="Sec1 family; Region: Sec1; cl15415" /db_xref="CDD:246954" RBS complement(6322..6325) /gene="kleA" /locus_tag="R751p12" -10_signal complement(6365..6370) /gene="kleA" /locus_tag="R751p12" protein_bind 6369..6386 /bound_moiety="KorC" -35_signal complement(6389..6394) /gene="kleA" /locus_tag="R751p12" protein_bind 6399..6408 /bound_moiety="KorA" protein_bind 6444..6456 /bound_moiety="KorB" gene complement(6473..6744) /gene="korC" /locus_tag="R751p13" /db_xref="GeneID:877482" CDS complement(6473..6730) /gene="korC" /locus_tag="R751p13" /function="regulation of gene expression" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044225.2" /db_xref="GI:15029582" /db_xref="GeneID:877482" /translation="MTNDANIRLECLKPAERWAQPSGEEVREVLRLAGLTGGKAAKVL GLGPKGDRTIRRWVGEDTPIPYAAWALLCDYAGLGLIWKEV" RBS 6740..6744 gene complement(6747..7968) /gene="klcB" /locus_tag="R751p14" /db_xref="GeneID:877462" CDS complement(6747..7952) /gene="klcB" /locus_tag="R751p14" /codon_start=1 /transl_table=11 /product="KlcB" /protein_id="NP_044226.2" /db_xref="GI:15029583" /db_xref="GeneID:877462" /translation="MAKRTKQPAQTGQDWSAPAAELLAELPADRDGLLAAAVAAVVEI DAAVMRGDGAAAELAGDRYEAIIWKLNGGTNFGCMADDEAAGRVIERHCAAVPGDVPL WGQRGQFLAVAGDVRALVEYEAGYGGPLNAHFQFHAVDLDRPFISATGYRSHFDTARG CMTVDEVARGILTAMLAEKKRPVLIEANYRDRLADAPLPDWLAGLVPPARREPATVTI PPGFVLVDVVLPAHKAFIARRWAAEAAGKVKAARAARSNAKGKAGGRERDPASAETAM RCSTAKADDCKAEAGPVSPEATMPGAGEASCSTARNGDAGPADLVEFTPAPGQRCEIV SVHHPVFAKEIGKRVIIVKVHPDTRQVWAHDDRPVTYKTNRAGRRVVDSDPSCIQSIY GFDQLRLIT" misc_feature complement(7209..>7409) /gene="klcB" /locus_tag="R751p14" /note="conjugal transfer protein TrbA; Provisional; Region: PRK13890" /db_xref="CDD:237547" RBS complement(7964..7968) /gene="klcB" /locus_tag="R751p14" repeat_region 7972..7997 /rpt_type=inverted gene complement(8004..8512) /gene="klcA" /locus_tag="R751p15" /db_xref="GeneID:877472" CDS complement(8004..8432) /gene="klcA" /locus_tag="R751p15" /function="possible anti-restriction system" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044227.1" /db_xref="GI:10955198" /db_xref="GeneID:877472" /translation="MNTQDQPVTASLVAEAQRLDFLPTYFGPRLMMRGEALVYAWLRR LCERYNGAYWHYYTLSDGGFYLAPDLAERLEIEVDGNGFRGELSADAAGIVATLFALG QLAAEIAGTDAADALIDRYHFLRGFAAGHPEAAAIYRAID" misc_feature complement(8007..8300) /gene="klcA" /locus_tag="R751p15" /note="Antirestriction protein; Region: Antirestrict; pfam03230" /db_xref="CDD:251814" RBS complement(8440..8443) /gene="klcA" /locus_tag="R751p15" -10_signal complement(8483..8488) /gene="klcA" /locus_tag="R751p15" protein_bind 8486..8504 /bound_moiety="KorC" -35_signal 8507..8512 protein_bind 8517..8526 /bound_moiety="KorA" protein_bind 8528..8540 /bound_moiety="KorB" protein_bind 8565..8579 /note="putative" /bound_moiety="KorC" gene 8601..8870 /gene="kluA" /locus_tag="R751p16" /db_xref="GeneID:877451" CDS 8601..8870 /gene="kluA" /locus_tag="R751p16" /codon_start=1 /transl_table=11 /product="KluA" /protein_id="NP_149414.1" /db_xref="GI:15029584" /db_xref="GeneID:877451" /translation="MRTTQQLSITLPNDMADVVKTKVKTGEYASESEVIRDGLRALLA RDRAVESWLHNQVGPAYDALKADPSRAVTADQVRARLAAEHAKAQ" misc_feature 8610..8867 /gene="kluA" /locus_tag="R751p16" /note="Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609" /db_xref="CDD:226136" gene 8867..9181 /gene="kluB" /locus_tag="R751p17" /db_xref="GeneID:877459" CDS 8867..9181 /gene="kluB" /locus_tag="R751p17" /codon_start=1 /transl_table=11 /product="KluB" /protein_id="NP_149415.1" /db_xref="GI:15029585" /db_xref="GeneID:877459" /translation="MSYAVVFSPEAEEQLAELYRYIAAAASPDVAARYTEAIVTYCES LRTFPLRGTMRDDVRPGLRITNYRKRAVIAFDVAGDLVSIIGVFYGGQDYETILHDDA DD" misc_feature 8879..9166 /gene="kluB" /locus_tag="R751p17" /note="Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668" /db_xref="CDD:226194" repeat_region complement(9180..9212) /rpt_type=direct repeat_region complement(9237..9253) /rpt_type=direct repeat_region complement(9323..9338) /rpt_type=direct gene 9438..9596 /locus_tag="R751p18" /db_xref="GeneID:3251110" CDS 9438..9596 /locus_tag="R751p18" /codon_start=1 /transl_table=11 /product="unidentified orf1" /protein_id="NP_044228.1" /db_xref="GI:10955199" /db_xref="GeneID:3251110" /translation="MKAVGRGATPLGGWEAALAAGWGSRRGGTPLRRPIILRGTLGRF AAFFDTRL" repeat_region 9452..9472 /note="unidentified orf1" /rpt_type=inverted gene 9476..9631 /locus_tag="R751p19" /db_xref="GeneID:3251111" CDS 9476..9631 /locus_tag="R751p19" /codon_start=1 /transl_table=11 /product="unidentified orf2" /protein_id="NP_044229.1" /db_xref="GI:10955200" /db_xref="GeneID:3251111" /translation="MGGRFSGRVGIEKGGHPPSAADHSAGHLGPVCRFFRHPVITTRF NIKVMKG" repeat_region 9482..9497 /note="unidentified orf2" /rpt_type=inverted repeat_region 9511..9531 /note="unidentified orf2" /rpt_type=inverted misc_feature 9591..9633 /note="A/T-rich region" repeat_region complement(9698..9714) /rpt_type=direct repeat_region complement(9699..9743) /rpt_type=direct repeat_region complement(9721..9737) /rpt_type=direct repeat_region complement(9766..9782) /rpt_type=direct gene complement(9780..9875) /locus_tag="R751p20" /db_xref="GeneID:3251112" CDS complement(9780..9875) /locus_tag="R751p20" /codon_start=1 /transl_table=11 /product="unidentified orf3" /protein_id="NP_044230.1" /db_xref="GI:10955201" /db_xref="GeneID:3251112" /translation="MCLIGLALSTEVVDKPVGKALAVLTLEGRGC" repeat_region complement(9789..9805) /note="unidentified orf3" /rpt_type=direct repeat_region 9810..9824 /note="unidentified orf3" /rpt_type=inverted gene complement(9832..9936) /locus_tag="R751p21" /db_xref="GeneID:3251113" CDS complement(9832..9936) /locus_tag="R751p21" /codon_start=1 /transl_table=11 /product="unidentified orf4" /protein_id="NP_044231.1" /db_xref="GI:10955202" /db_xref="GeneID:3251113" /translation="MRGRPRNRPAGAAPEAVEAAYVLDRAGFIHRSCG" repeat_region 9832..9854 /note="unidentified orf4" /rpt_type=inverted RBS complement(9882..9885) /locus_tag="R751p21" /note="unidentified orf3" repeat_region complement(9898..9982) /rpt_type=direct repeat_region complement(9926..9942) /rpt_type=direct repeat_region complement(9961..9977) /rpt_type=direct misc_feature 10032..10111 /note="identical to a region of Tn501 merR proximal end from the Pseudomonas aeruginosa plasmid pVS: EMBL Accession Number Z0027" misc_feature 10112..10133 /note="similar to Tn501 and Tn21 merR proximal end: EMBL Accession Number Z00027" misc_feature 10114..11460 /note="putative insertion sequence IS4321L; similar to Yersinia enterocolitica insertion sequence IS1328: EMBL Accession Number Z48244, Serratia marcescens plasmid pDU1358: GenBank Accession Number M24940 and Klebsiella pneumoniae plasmid pCFF04: EMBL Accession Number X64523" repeat_region 10117..10127 /note="probable transposase binding site" /rpt_type=inverted gene complement(10389..11393) /gene="tnpA" /locus_tag="R751p22" /db_xref="GeneID:877444" CDS complement(10389..11393) /gene="tnpA" /locus_tag="R751p22" /function="transposase for IS4321L, based on similarity to transposases of other IS elements including IS1111a from Coxiella burnetii, IS116 from Streptomyces clavuligerus, Mycobacterium paratuberculosis and IS1000 from Thermus thermophilus" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044232.1" /db_xref="GI:10955203" /db_xref="GeneID:877444" /translation="MENIALIGIDLGKNSFHIHCQDRRGKAVYRKKFTRPKLIEFLAT CPATTIAMEACGGSHFMARKLEELGHFPKLISPQFVRPFVKSNKNDFVDAEAICEAAS RPSMRFVQPRTESQQAMRALHRVRESLVQDKVKTTNQMHAFLLEFGISVPRGAAVISR LSTLLEDNSLPLYLSQLLLKLQQHYHYLVEQIKDLESQLKRKLDEDEIGQRLLSIPCV GTLTASTISTEIGDGKQYASSRDFAAATGLVPRQYSTGGRTTLLGISKRGNKKIRTLL VQCARVFIQKLEHQSGKLADWVRDLLCRKSNFVVTCALANKLARIAWALTARQQTYVA " misc_feature complement(10419..11378) /gene="tnpA" /locus_tag="R751p22" /note="Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547" /db_xref="CDD:226077" misc_feature complement(10977..11375) /gene="tnpA" /locus_tag="R751p22" /note="Transposase; Region: DEDD_Tnp_IS110; pfam01548" /db_xref="CDD:216564" misc_feature complement(10536..10766) /gene="tnpA" /locus_tag="R751p22" /note="Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371" /db_xref="CDD:217002" -10_signal complement(11422..11427) repeat_region 11443..11453 /note="probable transposase binding site" /rpt_type=inverted -35_signal complement(11447..11452) misc_feature 11461..11656 /note="similar to Tn501 merR 3' end: EMBL Accession Z00027" gene complement(11735..12157) /locus_tag="R751p22a" /db_xref="GeneID:3251114" CDS complement(11735..12157) /locus_tag="R751p22a" /function="possible polypeptide cyclase on basis of weak similarity to TcmJ of Streptomyces glauscens, GenBank Accession Number M80674" /note="orf1" /codon_start=1 /transl_table=11 /product="Pep1" /protein_id="NP_044233.1" /db_xref="GI:10955204" /db_xref="GeneID:3251114" /translation="MNRRTKLLAALSGAALAVSAAYAQDPKDVPQKTGVTPNDLVVRG VDGAENLEFIVIDVKYEPGGINRRHYHPAAVTFYVLSGTPVFQEEGKEPVTLKPGDSL LVPAGTTHSHWNPSRTQGVRWLEFIVAERGKGKSIRKP" misc_feature complement(11786..11986) /locus_tag="R751p22a" /note="Cupin domain; Region: Cupin_2; pfam07883" /db_xref="CDD:254486" RBS complement(12166..12168) /note="orf1" -35_signal 12211..12216 /note="orf2" -10_signal 12233..12238 /note="orf2" -10_signal complement(12234..12239) /note="orf1" RBS 12249..12251 /note="orf2" -35_signal 12255..12260 /note="orf1" gene 12260..13222 /locus_tag="R751p23" /db_xref="GeneID:3251115" CDS 12260..13222 /function="gene regulation based on sequence similarity to members of the LysR family of bacteria regulator proteins" /note="orf2 (based on pattern)" /codon_start=1 /transl_table=11 /product="Pep2" /protein_id="NP_044234.1" /db_xref="GI:10955205" /translation="MSPTDAVARHVTLRELRLLLAVARSGSILKAANEIGLTQPALSR SIADLEGAFGVRLFDRTNRGVAPTPHGEVLLRRATGVFEELRQAVNELRALADAAHGE LRIGGTPAMCAGLLPRIIGTVRSDRPRLQFHVAELESGPLASEVVGRSLDLGLGREHA VRESHDLVFEGLFEDRLFVVAGSQHPLAERRSISLEETLRHHWVLPTEGAVTAHLQGE FGRQGLAIPEAAITTMSMLVRCELIATGSFLTVMYGSVLRFGNAPKSLRVLPVDLPSG IPVGVIRLKNRTLAPSAEMFIQASRRMVRSMPSLSASQLRRARP" misc_feature 12293..13186 /note="Transcriptional regulator [Transcription]; Region: LysR; COG0583" /db_xref="CDD:223656" misc_feature 12296..12475 /note="Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126" /db_xref="CDD:249610" misc_feature 12566..13156 /note="The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398" /db_xref="CDD:264351" misc_feature order(12608..12613,12617..12622,12629..12631,12641..12643, 12647..12667,12947..12964,12980..12985,12989..12994) /note="dimerization interface [polypeptide binding]; other site" /db_xref="CDD:176102" misc_feature 12336..12395 /note="encodes an helix-turn-helix motif; orf2 (based on pattern)" misc_feature 13404..14729 /note="putative insertion sequence IS4321R; similar to Yersinia enterocolitica insertion sequence IS1328: EMBL Accession Number Z48244, Serratia marcescens plasmid pDU1358: GenBank Accession Number M24940 and Klebsiella pneumoniae plasmid pCFF04: EMBL Accession Number X64523" repeat_region 13411..13421 /note="probable transposase binding site" /rpt_type=inverted -35_signal 13412..13417 -10_signal 13434..13440 RBS complement(13459..13462) gene 13470..14474 /locus_tag="R751p24" /db_xref="GeneID:3251116" CDS 13470..14474 /locus_tag="R751p24" /function="transposase for IS4321R; for basis see note for tnpA of IS4321L" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044235.1" /db_xref="GI:10955206" /db_xref="GeneID:3251116" /translation="MENIALIGIDLGKNSFHIHCQDRRGKAVYRKKFTRPKLIEFLAT CPSTTIAMEACGGSHFMARKLEELGHSPKLISPQFVRPFVKSNKNDFVDAEAICEAAS RPSMRFVQPRTESQQAMRALHRVRESLVQDKVKTTNQMHAFLLELGISVPRGAAVISR LSTILEDNSLPLYLSQLLLKLQQHYHYLVEQIKDLESQLKRKLDEDEVGQRLLSIPCV GTLTASTISTEIGDGKQYASSRDFAAATGLVPRQYSTGGRTTLLGISKRGNKKIRTLL VQCARVFIQKLEHQSGKLADWVRDLLCRKSNFVVTCALANKLARIAWALTARQQTYVA " misc_feature 13485..14444 /locus_tag="R751p24" /note="Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547" /db_xref="CDD:226077" misc_feature 13488..13886 /locus_tag="R751p24" /note="Transposase; Region: DEDD_Tnp_IS110; pfam01548" /db_xref="CDD:250699" misc_feature 14097..14327 /locus_tag="R751p24" /note="Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371" /db_xref="CDD:251256" repeat_region 14716..14726 /note="probable transposase binding site" /rpt_type=inverted misc_feature 14730..14741 /note="an inverted repetition of this sequence occurs at nucleotides 10026..10047" protein_bind 14947..14961 /bound_moiety="TrfA" repeat_region complement(14975..14993) /rpt_type=direct repeat_region complement(15015..15032) /rpt_type=direct repeat_region complement(15046..15065) /rpt_type=direct repeat_region complement(15092..15111) /rpt_type=direct repeat_region complement(15149..15168) /rpt_type=direct terminator 15175..15203 gene complement(15226..16460) /gene="trfA1" /locus_tag="R751p25" /db_xref="GeneID:877461" CDS complement(15226..16449) /gene="trfA1" /locus_tag="R751p25" /function="initiation of vegetative plasmid replication; DNA binding" /codon_start=1 /transl_table=11 /product="TrfA1" /protein_id="NP_044236.1" /db_xref="GI:10955207" /db_xref="GeneID:877461" /translation="MQNEFNEQEYRRKLIEGGLSEADATDLAARTAAARRDSGSAGGA FRPAGSLFELPATAGDNEAALPPKLPTPASAAVERSERMAQESAELARTMGLPPEPRT AVNKMAEQIGALAQDKRSSAMATKKRTAGGELAEKVSEAKQTALLKHTKQQIKDMQLS LFDLAPWTGSHAALPNDFGRSAIFTVRNKKVPRPALQGQSIYHVNKDVEITYTGIELR ADDDELVFAQVLEYANGTALGEPVSFTFYELCQDLDWSINGRYYTRAEECLTRLQASA MQFSSQRIGRLESVSLIRRFRVLDRGKRTSRCQVEIDAEIVVLFAGDHYTKFVWEKYR KLSPNRDGRMFDYFATHKEPYPLKLETFRLMCGSDSTRPKKWREQVGEACDELRENGL VESAWVNDDLVHCKR" misc_feature complement(15229..16074) /gene="trfA1" /locus_tag="R751p25" /note="TrfA protein; Region: TrfA; pfam07042" /db_xref="CDD:115680" gene complement(15226..16096) /gene="trfA2" /locus_tag="R751p26" /db_xref="GeneID:877447" CDS complement(15226..16083) /gene="trfA2" /locus_tag="R751p26" /note="initiation of vegetative plasmid replication; DNA binding" /codon_start=1 /transl_table=11 /product="S-TrfA" /protein_id="NP_044237.1" /db_xref="GI:10955208" /db_xref="GeneID:877447" /translation="MATKKRTAGGELAEKVSEAKQTALLKHTKQQIKDMQLSLFDLAP WTGSHAALPNDFGRSAIFTVRNKKVPRPALQGQSIYHVNKDVEITYTGIELRADDDEL VFAQVLEYANGTALGEPVSFTFYELCQDLDWSINGRYYTRAEECLTRLQASAMQFSSQ RIGRLESVSLIRRFRVLDRGKRTSRCQVEIDAEIVVLFAGDHYTKFVWEKYRKLSPNR DGRMFDYFATHKEPYPLKLETFRLMCGSDSTRPKKWREQVGEACDELRENGLVESAWV NDDLVHCKR" misc_feature complement(15229..16074) /gene="trfA2" /locus_tag="R751p26" /note="TrfA protein; Region: TrfA; pfam07042" /db_xref="CDD:115680" RBS complement(16091..16096) /gene="trfA2" /locus_tag="R751p26" RBS complement(16453..16460) /gene="trfA1" /locus_tag="R751p25" gene complement(16496..16852) /gene="ssb" /locus_tag="R751p27" /db_xref="GeneID:877448" CDS complement(16496..16837) /gene="ssb" /locus_tag="R751p27" /function="single strand DNA binding protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044238.1" /db_xref="GI:10955209" /db_xref="GeneID:877448" /translation="MSHNLFQFIGNLTRDTDVRHSENSARAVFDLAVNRVWRNAAGAK QEQTDFFRIKSFGGLAENAGKYLGKGSKVFVQGRIEPTKYEKDGKTEYGFDFIAEEIE YLDTKAPGGGQ" misc_feature complement(<16499..16837) /gene="ssb" /locus_tag="R751p27" /note="Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629" /db_xref="CDD:223702" misc_feature complement(16526..16822) /gene="ssb" /locus_tag="R751p27" /note="SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496" /db_xref="CDD:239942" misc_feature complement(order(16556..16558,16565..16567,16595..16597, 16622..16624,16685..16687,16691..16693,16733..16741, 16811..16822)) /gene="ssb" /locus_tag="R751p27" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:239942" misc_feature complement(order(16547..16549,16553..16555,16589..16594, 16598..16600,16604..16606,16628..16633,16670..16672, 16676..16678,16682..16684,16688..16690,16694..16699, 16730..16735,16754..16756,16781..16783,16799..16807)) /gene="ssb" /locus_tag="R751p27" /note="ssDNA binding site [nucleotide binding]; other site" /db_xref="CDD:239942" misc_feature complement(order(16532..16534,16610..16612,16616..16618, 16622..16624)) /gene="ssb" /locus_tag="R751p27" /note="tetramer (dimer of dimers) interface [polypeptide binding]; other site" /db_xref="CDD:239942" gene 16778..17313 /gene="trbA" /locus_tag="R751p28" /db_xref="GeneID:877455" -35_signal 16778..16783 /gene="trbA" /locus_tag="R751p28" -10_signal 16801..16806 /gene="trbA" /locus_tag="R751p28" RBS complement(16846..16852) /gene="ssb" /locus_tag="R751p27" gene complement(16869..16897) /gene="trfA" /locus_tag="R751p29" /db_xref="GeneID:877442" -10_signal complement(16869..16874) /gene="trfA" /locus_tag="R751p29" protein_bind 16871..16880 /bound_moiety="KorA protein" -35_signal complement(16892..16897) /gene="trfA" /locus_tag="R751p29" protein_bind 16902..16914 /bound_moiety="KorB protein" RBS 16937..16940 /gene="trbA" /locus_tag="R751p28" CDS 16951..17313 /gene="trbA" /locus_tag="R751p28" /function="gene regulation" /note="TrbA repressor" /codon_start=1 /transl_table=11 /product="conjugal transfer protein TrbA" /protein_id="NP_044239.1" /db_xref="GI:10955210" /db_xref="GeneID:877455" /translation="MYNYIFFTNVLRLLDERHMTKKELSDRSGVSISFLSDLTTGKAN PSLKVMEDIAQALETPLPLLLESTDLDKEALDALAGGKAPRSLPPGFERVAAVLPEHQ AFIVKKWGEATRKKLRGS" misc_feature 16951..17310 /gene="trbA" /locus_tag="R751p28" /note="conjugal transfer protein TrbA; Provisional; Region: PRK13890" /db_xref="CDD:237547" misc_feature 16984..17118 /gene="trbA" /locus_tag="R751p28" /note="Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093" /db_xref="CDD:238045" misc_feature order(16990..16992,17065..17067) /gene="trbA" /locus_tag="R751p28" /note="salt bridge; other site" /db_xref="CDD:238045" misc_feature order(16993..16995,17068..17070) /gene="trbA" /locus_tag="R751p28" /note="non-specific DNA binding site [nucleotide binding]; other site" /db_xref="CDD:238045" misc_feature order(17011..17016,17047..17049,17056..17058,17068..17073) /gene="trbA" /locus_tag="R751p28" /note="sequence-specific DNA binding site [nucleotide binding]; other site" /db_xref="CDD:238045" protein_bind 17375..17387 /bound_moiety="KorB protein" gene 17539..18580 /gene="trbB" /locus_tag="R751p30" /db_xref="GeneID:877441" -35_signal 17539..17544 /gene="trbB" /locus_tag="R751p30" misc_feature 17545..17559 /gene="trbB" /locus_tag="R751p30" /note="palindrome (OX)" -10_signal 17560..17564 /gene="trbB" /locus_tag="R751p30" RBS 17605..17612 /gene="trbB" /locus_tag="R751p30" CDS 17618..18580 /gene="trbB" /locus_tag="R751p30" /function="ATPase autophosphorylase" /codon_start=1 /transl_table=11 /product="conjugal transfer ATPase TrbB" /protein_id="NP_044240.1" /db_xref="GI:10955211" /db_xref="GeneID:877441" /translation="MTDQKPEHNSIKERAKKKLERDMGPELLAALNDPKTVEIMLNAD GKLWLERLGEPMKCIGTLRVAQAQAIIETIAGYHGKEVTRSKPILEGELPLDGSRFAG QLPPVVPAPTFAIRKKGVAIFTLDQYVERGIMTAPQREALIAAVRAHRNILVIGGTGS GKTTLVNAIINEMVIQDPTERVFIIEDTGEIQCAAENYVQYHTSIDVNMTALLKTTLR MRPDRILVGEVRGPEALDLLMAWNTGHEGGAATLHANNAKAGLDRLAMLISMHPDSPK PIEPLIGEAVHVVVHIARVEGSRRIQEILEVSGFANGQYITKTL" misc_feature 17621..18577 /gene="trbB" /locus_tag="R751p30" /note="conjugal transfer ATPase TrbB; Provisional; Region: PRK13894" /db_xref="CDD:184377" misc_feature 17990..18535 /gene="trbB" /locus_tag="R751p30" /note="Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130" /db_xref="CDD:238550" misc_feature order(17999..18001,18092..18109,18512..18514) /gene="trbB" /locus_tag="R751p30" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:238550" misc_feature order(18083..18088,18098..18106) /gene="trbB" /locus_tag="R751p30" /note="Walker A motif; other site" /db_xref="CDD:238550" misc_feature order(18089..18094,18158..18160,18182..18184,18203..18214, 18218..18223,18269..18277,18281..18283,18320..18322, 18332..18334,18341..18346,18374..18382,18392..18394, 18401..18403,18497..18499) /gene="trbB" /locus_tag="R751p30" /note="hexamer interface [polypeptide binding]; other site" /db_xref="CDD:238550" misc_feature 18284..18301 /gene="trbB" /locus_tag="R751p30" /note="Walker B motif; other site" /db_xref="CDD:238550" gene 18583..19061 /gene="trbC" /locus_tag="R751p31" /db_xref="GeneID:877437" RBS 18583..18587 /gene="trbC" /locus_tag="R751p31" CDS 18597..19061 /gene="trbC" /locus_tag="R751p31" /function="mating pair formation (mpf) during bacterial conjugation" /note="cleavage point for export signal sequence between amino acids 36..37" /codon_start=1 /transl_table=11 /product="conjugal transfer protein TrbC" /protein_id="NP_044241.1" /db_xref="GI:10955212" /db_xref="GeneID:877437" /translation="MQATFPAFRLNRNALFYMGLFALLAFFLLAPQHAFASEGTGGSL PYESWLTNLRNSVTGPVAFALSIIGIVVAGGILIFGGELNGFLRTLIFIVLVMGLLVG AQNMMSTFFGRGAEIAALTDGALHQVKVAALDVAGFPGEAVMRWAERGHIAG" misc_feature 18597..18998 /gene="trbC" /locus_tag="R751p31" /note="conjugal transfer protein TrbC; Provisional; Region: PRK13892" /db_xref="CDD:184376" misc_feature 18637..18690 /gene="trbC" /locus_tag="R751p31" /note="encodes a hydrophobic region" gene 19055..19376 /gene="trbD" /locus_tag="R751p32" /db_xref="GeneID:877466" RBS 19055..19058 /gene="trbD" /locus_tag="R751p32" CDS 19065..19376 /gene="trbD" /locus_tag="R751p32" /codon_start=1 /transl_table=11 /product="conjugal transfer protein TrbD" /protein_id="NP_044242.1" /db_xref="GI:10955213" /db_xref="GeneID:877466" /translation="MALRAIPIRRAGNRENLFMGGDRELVMFSGLCGGALIFSAQEVR ATVFGIALWFGALFALRLMAKADPKLRHVYLRHRRYKPYYPARSTPFRDNTPSQGKQY K" misc_feature 19065..19346 /gene="trbD" /locus_tag="R751p32" /note="conjugal transfer protein TrbD; Provisional; Region: PRK13823" /db_xref="CDD:184348" misc_feature 19174..19233 /gene="trbD" /locus_tag="R751p32" /note="encodes a bacterial leucine zipper motif" gene 19361..21931 /gene="trbE" /locus_tag="R751p33" /db_xref="GeneID:877453" RBS 19361..19364 /gene="trbE" /locus_tag="R751p33" CDS 19373..21931 /gene="trbE" /locus_tag="R751p33" /function="mpf" /note="type IV secretion system ATPase VirB4 family" /codon_start=1 /transl_table=11 /product="conjugal transfer protein TrbE" /protein_id="NP_044243.1" /db_xref="GI:10955214" /db_xref="GeneID:877453" /translation="MIEAIAIAIAVLGAVLLLILFARIRAVDAELKLKKHRAKDAGLA DLLNYAAAVDDGVIVGKNGSFMAAWLYKGDDNASSTEEQREMVSFRINQALAGLGNGW MVHVDAVRRPAPNYSERGVSSFPDSVSFAIDEERRRLFEGLGAMFEGYFVLTVTWFPP VLAQRKFVELMFDDDAVAPDHTARTTGLIAQFKREITSLESRLSSAVKMTRLGGQKVV SEEGREVTHDDFLSWLQFCVTGLHHPVMLPSNPMYLDAVIGGQELWGGVVPKIGRKFI QVVAIEGFPLESTPGVLSALAELPSEYRWSSRFIFMDQHESLKHLDKFRKKWKQKIRG FFDQVFNTNTGSINQDAAAMVGDAEAAIAEVNSGLVAAGYYTSVVVLMDEDRERLAAS ALLVEKAVNRLAFAARIETINTLDAYLGSLPGHGVENVRRPLINTMNLADLLPTSSIW TGSATAPCPMYPPLSPALMHCVTVGATPFRLNLHVRDLGHTFMFGPTGAGKSTHLGII AAQLRRYAGMSIYAFDKGMSMYPLAAGIRAATKGKSGLHFTVAADDDRLAFCPLQFLE TKGDRAWAMEWIDTILALNGVNTTPAQRNEIGNAIMSMHASGARTLSEFSVTIQDEAI REGIKQYTVDGSMGHLLDAEEDGLSLSDFTVFEIEELMNLGEKFALPVLLYLFRRIER ALKGQPSVIILDEAWLMLGHPAFRAKIREWLKVLRKANCLVLMATQSLSDAANSGILD VIVESTATKIFLPNVYARDEDTSALYRRMGLNARQIEILATAIPKRQYYYVSENGRRL YDLALGPMALAFVGASDKESVATIKSLEAKFGHEWVHEWLAARGLNLNDYLETA" misc_feature 19403..21928 /gene="trbE" /locus_tag="R751p33" /note="conjugal transfer protein TrbE; Provisional; Region: PRK13891" /db_xref="CDD:184375" misc_feature 20018..20665 /gene="trbE" /locus_tag="R751p33" /note="CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135" /db_xref="CDD:251751" misc_feature 20840..>21205 /gene="trbE" /locus_tag="R751p33" /note="RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233" /db_xref="CDD:266574" misc_feature order(20855..20860,20870..20878) /gene="trbE" /locus_tag="R751p33" /note="Walker A motif; other site" /db_xref="CDD:238540" misc_feature order(20858..20860,20870..20878,20933..20935,20942..20947, 21107..21112) /gene="trbE" /locus_tag="R751p33" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:238540" misc_feature order(21089..21097,21104..21109) /gene="trbE" /locus_tag="R751p33" /note="Walker B motif; other site" /db_xref="CDD:238540" misc_feature <21404..21583 /gene="trbE" /locus_tag="R751p33" /note="ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267" /db_xref="CDD:213179" misc_feature 21440..21457 /gene="trbE" /locus_tag="R751p33" /note="Walker B; other site" /db_xref="CDD:213179" misc_feature order(21464..21472,21476..21478) /gene="trbE" /locus_tag="R751p33" /note="D-loop; other site" /db_xref="CDD:213179" misc_feature 21542..21562 /gene="trbE" /locus_tag="R751p33" /note="H-loop/switch region; other site" /db_xref="CDD:213179" misc_feature 21267..21290 /gene="trbE" /locus_tag="R751p33" /note="encodes a nucleotide binding motif" gene 21919..22710 /gene="trbF" /locus_tag="R751p34" /db_xref="GeneID:877438" RBS 21919..21923 /gene="trbF" /locus_tag="R751p34" CDS 21928..22710 /gene="trbF" /locus_tag="R751p34" /function="mpf" /codon_start=1 /transl_table=11 /product="conjugal transfer protein TrbF" /protein_id="NP_044244.1" /db_xref="GI:10955215" /db_xref="GeneID:877438" /translation="MSIADTLKGLIFKKPANSAEPRDPRRSKEPLAGGRRAGEAENPY LAARRTWNDHVGGVVSQRQTWQVIGILSLLIALAGVGGVIHIGSQSKFIPYVVEVDKL GQTVAAGPVQAAGKADPRVIHAAVADWMSCARMVSPDVALQRKCVFKAYSMFAPNDPA TPKMNEWLNGTPDSSPFKRAEKEMVSVEIKTVIPQTPDTWQVEWVETTRDRQGTLKGQ PVTWRALVTTYIAEVTPNTTDEQLRNNPLSIYVRDYSWSRIQ" misc_feature 21928..22707 /gene="trbF" /locus_tag="R751p34" /note="conjugal transfer protein TrbF; Provisional; Region: PRK13887" /db_xref="CDD:237544" gene 22694..23627 /gene="trbG" /locus_tag="R751p35" /db_xref="GeneID:877446" RBS 22694..22696 /gene="trbG" /locus_tag="R751p35" CDS 22707..23627 /gene="trbG" /locus_tag="R751p35" /function="mating pair formation" /note="type IV secretion system VirB9/CagX family" /codon_start=1 /transl_table=11 /product="conjugal transfer protein TrbG" /protein_id="NP_044245.1" /db_xref="GI:10955216" /db_xref="GeneID:877446" /translation="MNSRSSTMKKTLSALIVGAAVAVPSLALAAPGDDIADKYFNKTN PTLTAQERAALAIAKRWEAGSATGIKPVAGSGGAIKFVYGAQQPSIVCAVLQVCDVAL QPGEQVNSINLGDTARWTVEPAITGSGATEVQHLIIKPMDVGLETSLVVITNRRSYHF RLRSHRTEYMPQVSFTYPEEAQAKWDAIQRREKQERTDNTLPVTGEYLGDLSFDYELS GSASWKPVRVYNDGRKTIIEMPGTMQQTEAPTLLVVRKEGGLFTDDETVLVNYRVQGN RYIVDTVFDRAILIAGVGSSQDRVTISRRK" misc_feature 23337..23624 /gene="trbG" /locus_tag="R751p35" /note="VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911" /db_xref="CDD:132874" misc_feature order(23343..23363,23376..23393,23568..23570,23595..23615) /gene="trbG" /locus_tag="R751p35" /note="VirB7 interaction site; other site" /db_xref="CDD:132874" misc_feature 22720..22755 /gene="trbG" /locus_tag="R751p35" /note="encodes a hydrophobic region" gene 23618..24118 /gene="trbH" /locus_tag="R751p36" /db_xref="GeneID:877443" RBS 23618..23621 /gene="trbH" /locus_tag="R751p36" CDS 23630..24118 /gene="trbH" /locus_tag="R751p36" /function="mating pair formation" /note="cleavage point for export signal sequence between amino acids 18..19" /codon_start=1 /transl_table=11 /product="conjugal transfer protein TrbH" /protein_id="NP_044246.1" /db_xref="GI:10955217" /db_xref="GeneID:877443" /translation="MRKIVSLALLALALGLGGCATTSQYGNFVQSAALDQQKLATDAV QQLATLYAPARTRLELQQPTPDPFGQALVNSLRDKGYALLEYAPAGASTQAPASAASQ ASAPATTAASGGLPLRYVLDQAGDSNLYRLTLMVGNQSITRPYLAQNGTFAPAGYWVR KE" misc_feature 23630..24115 /gene="trbH" /locus_tag="R751p36" /note="conjugal transfer protein TrbH; Provisional; Region: PRK13883" /db_xref="CDD:184367" misc_feature 23649..23669 /gene="trbH" /locus_tag="R751p36" /note="encodes a hydrophobic region" gene 24111..25544 /gene="trbI" /locus_tag="R751p37" /db_xref="GeneID:877458" RBS 24111..24115 /gene="trbI" /locus_tag="R751p37" CDS 24123..25544 /gene="trbI" /locus_tag="R751p37" /function="mating pair formation" /codon_start=1 /transl_table=11 /product="conjugal transfer protein TrbI" /protein_id="NP_044247.1" /db_xref="GI:10955218" /db_xref="GeneID:877458" /translation="MTENADQMAPDASPGEVSKKAGVRRVNNMPMYILGGVLLSFVLV MALVAADRAAKQNAPADGPKEKAGNTSMFAKEIAGDKTGGLIEPASPLKVPDMPTGPA SAPLEIARPSNPEAPPAPPANPGNPGQPVNDDEAQRIRMAKMQMFGEAVKAKTTVRVD GPRSNGSAPGGPSTYTGTPQTRDEMLNRIAAVQQQIDAQRSNDPTAAYQARLAQIRGM GVGGGGAAPAAGGMGAGGAPQLLQTSTSGGGRNSMAQFGQGGQGDRWKLDSQPEAPRT PFELRAGFVVPATLISGINSDLPGQIMAQVAQDVYDTPTGKHLLIPQGSRLVGSYSSD VAYGQARVLVAWQRIVFPDGKAMDIGAMPGADSAGYAGFHDQVNNHYVRLFGSAFLMS GVTAGITYSQRQNQATNTYGAPSASSALSEALGQQLGQVTAQLIAKNLSISPTLEIRP GYRFNVVVTKDMTFSKPYRSFDY" misc_feature 24123..25541 /gene="trbI" /locus_tag="R751p37" /note="conjugal transfer protein TrbI; Provisional; Region: PRK13881" /db_xref="CDD:237541" misc_feature <24936..25541 /gene="trbI" /locus_tag="R751p37" /note="Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948" /db_xref="CDD:225499" gene 24551..26329 /gene="trbJ" /locus_tag="R751p38" /db_xref="GeneID:877460" RBS 24551..25555 /gene="trbJ" /locus_tag="R751p38" CDS 25565..26329 /gene="trbJ" /locus_tag="R751p38" /function="mating pair formation and entry exclusion" /note="cleavage point for export signal sequence between amino acids 21..22" /codon_start=1 /transl_table=11 /product="conjugal transfer protein TrbJ" /protein_id="NP_044248.1" /db_xref="GI:10955219" /db_xref="GeneID:877460" /translation="MKPKFLAAKLALVIAVSSTLAVTPVQAGIPVIDGTNLSQNIMTA IESVAQTLKQIEQYSTQLQQYQNQLQNTMAPAAYIWDQAQSTINGLMNAVNTLDYYKT QLGSLDSYIGKFQDVNYYKNSPCFTAAGCSDAERAALRNVAQLASESQKKANDALFKG LDRQQTNLTADAATLQRLQSAAQGAQGQMQAIGYANQLASQQANQLLQIRGLLIAQQN AMATKMQADADKEAQQAAAAAQLRQGSYRASPARTW" misc_feature 25574..26326 /gene="trbJ" /locus_tag="R751p38" /note="conjugal transfer protein TrbJ; Provisional; Region: PRK13879" /db_xref="CDD:184363" protein_bind 25579..25591 /bound_moiety="KorB" misc_feature 25581..25613 /gene="trbJ" /locus_tag="R751p38" /note="encodes a hydrophobic region" gene 26327..26567 /gene="trbK" /locus_tag="R751p39" /db_xref="GeneID:877445" RBS 26327..26334 /gene="trbK" /locus_tag="R751p39" CDS 26340..26567 /gene="trbK" /locus_tag="R751p39" /function="entry exclusion" /note="cleavage point for export signal sequence between amino acids 21..22" /codon_start=1 /transl_table=11 /product="TrbK" /protein_id="NP_044249.1" /db_xref="GI:10955220" /db_xref="GeneID:877445" /translation="MKAIKALSLASAALVAALVAGCDNKPATAPMPEVNDESCKPENI AKIEDKGVQQAFSSLCLRRGGDFKPSPKREW" misc_feature <26400..26564 /gene="trbK" /locus_tag="R751p39" /note="entry exclusion lipoprotein TrbK; Region: TrbK_RP4; TIGR04359" /db_xref="CDD:234560" misc_feature 26356..26397 /gene="trbK" /locus_tag="R751p39" /note="encodes a hydrophobic region" gene 26566..28296 /gene="trbL" /locus_tag="R751p40" /db_xref="GeneID:877475" RBS 26566..26570 /gene="trbL" /locus_tag="R751p40" CDS 26578..28296 /gene="trbL" /locus_tag="R751p40" /function="mating pair formation" /note="cleavage point for export signal sequence between amino acids 27..28" /codon_start=1 /transl_table=11 /product="TrbL" /protein_id="NP_044250.1" /db_xref="GI:10955221" /db_xref="GeneID:877475" /translation="MRMPANLKTLALPLFVWLAFFAVDAHAAIDNAGVFDSVLDRYQT AASGWAGVITTAATWLFWTLVVISMVWTFGMMALRKADIGEFFAEFVRFTIFTGFFWW ALTNGPNFASSIYASLRQLAGNATGLGNALSPSGIVDVGFAIFDKVMDQSSVWSPVDS MAGILMAVAILVILALVGVNMLLLLASGWVLAYGGVFFLGFGGSRWTSDMAINYYKVV LGVAAQLFAMVLLVGIGKTFLDDYYSRMSAGISLKEMGVMLIVVIILLALVNKIPPLI AGIITGASVGGAGIGQFGAGAALGAAGMAAAAAATGGAALAAGAASAAGGASAVMAAF SKANENVSAGTDVMSAFSGGGSSGGGAGGGGDAGTGSTPFAQAAGFSGSSGGGSSSGG GSPSTGSSSGSSKGGDKGGGKADAGGQGSSSTASTGSSADKAAKNEPKPAGGAGQGQQ AAPGSTGPGLLASAASALGTAGRIAADAGANLAKGTADVAKAKAASLREAAAERIADT TGGKIAAAIKAQGSGTAENIDVPDQQPAPSFGDNRLAGGPADADPESEVAAFANREQG RDGTTA" misc_feature 26665..27444 /gene="trbL" /locus_tag="R751p40" /note="TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503" /db_xref="CDD:260967" misc_feature <27940..28266 /gene="trbL" /locus_tag="R751p40" /note="hypothetical protein; Provisional; Region: PRK12495" /db_xref="CDD:183558" misc_feature 26606..26641 /gene="trbL" /locus_tag="R751p40" /note="encodes a hydrophobic region" gene 28299..28901 /gene="trbM" /locus_tag="R751p41" /db_xref="GeneID:877439" RBS 28299..28304 /gene="trbM" /locus_tag="R751p41" CDS 28314..28901 /gene="trbM" /locus_tag="R751p41" /function="probable role in the formation of the mating lock (cell-cell contact between donor and recipient) during conjugation on the basis that TrbM shows homology to Haemophilus influenzae adhesin and has an export signal sequence" /note="cleavage point for export signal sequence between amino acids 24..25" /codon_start=1 /transl_table=11 /product="conjugal transfer protein TrbM" /protein_id="NP_044251.2" /db_xref="GI:113911682" /db_xref="GeneID:877439" /translation="MKKKLFALAALVAALGSTAGTASAQDVLTGDTRLACEAILCLSS GTRPSECTPSLSRYFNITKRKLSDTIRARLNFLQLCPVASQTPEMQSLVSAISRGAGR CDAQSLNSTLVMWTGGYDDGRTYISNQLPDYCGAYTGHAYTDFASSGTLPRYVGTPER GGYWVEARDYDRALAEYNERIRREDEERRRQSWLN" misc_feature 28314..28898 /gene="trbM" /locus_tag="R751p41" /note="conjugal transfer protein TrbM; Provisional; Region: PRK13893" /db_xref="CDD:237548" misc_feature 28327..28368 /gene="trbM" /locus_tag="R751p41" /note="encodes a hydrophobic region" gene 28908..29550 /gene="trbN" /locus_tag="R751p42" /db_xref="GeneID:877456" RBS 28908..28912 /gene="trbN" /locus_tag="R751p42" CDS 28915..29550 /gene="trbN" /locus_tag="R751p42" /function="mating pair formation" /codon_start=1 /transl_table=11 /product="conjugal transfer protein TrbN" /protein_id="NP_044252.1" /db_xref="GI:10955223" /db_xref="GeneID:877456" /translation="MPFFADLPPQLQERVVCSISAAVKYEVPVNIVLAVAEKEGGKPG QWVRNSNGTHDVGPMQFNTAYLGDLARYGITANDVAAAGCYSFDLAAWRLRMHIRNDK GDLWTKAANYHSRTPQYNAVYRADLMRKASKWADWLEARFVTLDVTKAGATPLTPSQP ATVAQRATPAARPAPAPQQAAPAAAAARSVSVAGYVPRTVSFNTSREGSAE" misc_feature 28999..29295 /gene="trbN" /locus_tag="R751p42" /note="Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254" /db_xref="CDD:238157" misc_feature order(29029..29031,29098..29100,29191..29193,29248..29250) /gene="trbN" /locus_tag="R751p42" /note="N-acetyl-D-glucosamine binding site [chemical binding]; other site" /db_xref="CDD:238157" misc_feature 29029..29031 /gene="trbN" /locus_tag="R751p42" /note="catalytic residue [active]" /db_xref="CDD:238157" gene 29566..29843 /gene="trbO" /locus_tag="R751p43" /db_xref="GeneID:877454" RBS 29566..29570 /gene="trbO" /locus_tag="R751p43" CDS 29577..29843 /gene="trbO" /locus_tag="R751p43" /function="unknown" /codon_start=1 /transl_table=11 /product="TrbO" /protein_id="NP_044253.1" /db_xref="GI:10955224" /db_xref="GeneID:877454" /translation="MDKFHAFMMRYTLGVGRLLQAYCKWAEGQAKNQLDLLLLGLGPI FALGLLLWALPAWIGKPIAFVLSLPALYIIFLVLRAYAIRGGRR" gene 29829..30541 /gene="trbP" /locus_tag="R751p44" /db_xref="GeneID:877436" gene 29829..29833 /gene="trb" /locus_tag="R751p45" /db_xref="GeneID:4246829" misc_feature 29829..29833 /gene="trb" /locus_tag="R751p45" RBS 29829..29833 /gene="trbP" /locus_tag="R751p44" CDS 29843..30541 /gene="trbP" /locus_tag="R751p44" /function="possible role in pillus assembly on the basis of analogy to (i) the TraX protein of E.coli, which is involved in the N-terminal modification of pilin for F-pilus synthesis and (ii) a possible fimbrial assembly protein F" /codon_start=1 /transl_table=11 /product="conjugal transfer protein TrbP" /protein_id="NP_044254.1" /db_xref="GI:10955225" /db_xref="GeneID:877436" /translation="MKALRIPDGTVEALKWLALVLMTGDHVNKYLFNATLPVLFEAGR VALPLFVFVLAYNLARRGTLERGVYGRTMSRLAMFGALASVPFVALGGLYAGWWPLNV MFTLLVVTATAYLVERGGKLHLAAAGVVFLVGGSSVEYWWPAVAFGLAVWSYTRRPSW AAAAVAVLACAALWFVNRNLWALAALPVLFLASRVDVRVPRLRWAFYAYYPLHLASLW LIRIPMSKAGYLFF" misc_feature 29843..30538 /gene="trbP" /locus_tag="R751p44" /note="conjugal transfer protein TrbP; Provisional; Region: PRK13882" /db_xref="CDD:237542" misc_feature 29867..30508 /gene="trbP" /locus_tag="R751p44" /note="TraX protein; Region: TraX; pfam05857" /db_xref="CDD:218781" gene 30544..30985 /gene="upf30.5" /locus_tag="R751p46" /db_xref="GeneID:877463" RBS 30544..30547 /gene="upf30.5" /locus_tag="R751p46" CDS 30557..30985 /gene="upf30.5" /locus_tag="R751p46" /function="the absence of a upf30.5 promoter sequence and the close proximity of this gene to trbP which is part of the Tra2 operon, whose genes are involved in mpf, together with findings which show that upf30.5 shows similarity to (i) OmpA adhesion protein of Bordetella avium, (ii) a porin in Leptothrix discophora and (iii) an outer membrane precursor for a root adhesin in Pseudomonas fluorescens, indicates a possible role for upf30.5 in mpf" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044255.1" /db_xref="GI:10955226" /db_xref="GeneID:877463" /translation="MRKPVLLALSLAFLVSAQSALAGDAGNFGTPIKSGVSVSFPDSS ATFQPTPEALELLADARNAAIIYISGRTSTLRPSAADEALALRRALSARSYLVARGVS PLKIMVNFASAADFVADNSTAEGRRENQRVDIEVVYIPTY" misc_feature 30662..30964 /gene="upf30.5" /locus_tag="R751p46" /note="Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931" /db_xref="CDD:243245" misc_feature order(30680..30685,30770..30775,30782..30784,30794..30799, 30806..30808,30932..30934,30944..30946) /gene="upf30.5" /locus_tag="R751p46" /note="ligand binding site [chemical binding]; other site" /db_xref="CDD:143586" repeat_region 30995..31014 /rpt_type=direct repeat_region 31039..31058 /rpt_type=direct gene 31078..31664 /gene="upf31.0" /locus_tag="R751p47" /db_xref="GeneID:877468" -35_signal 31078..31083 /gene="upf31.0" /locus_tag="R751p47" repeat_region 31085..31104 /rpt_type=direct -10_signal 31100..31106 /gene="upf31.0" /locus_tag="R751p47" RBS 31128..31133 /gene="upf31.0" /locus_tag="R751p47" CDS 31140..31664 /gene="upf31.0" /locus_tag="R751p47" /function="putative adenine methylase on basis of (i) similarity to a hypothetical adenine specific methylase from the FIS-ENVR intergenic regions (ORF2) in E.coli and (ii) the presence of the VYADDPY motif for N-6 adenine specific methylases encoded by nucleotides 31322..31342 (amino acids 89..95)" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044256.1" /db_xref="GI:10955227" /db_xref="GeneID:877468" /translation="MRYPGGKGGAGVYQTIINNIPPHDTYIETHLGGGNILERKRPAA RSVGIDVDPEVIEVWQQLDVPGLELHHGDAVAWLESHQFTGSEFVYADPPYVMDSRRG GKLYRHEYDDADHVRLLDVLAGLPCAVMVSGYSSTIYDSSPLASWRTIDFNAMTRGGI AIERLWMNYPEPAE" misc_feature 31233..>31424 /gene="upf31.0" /locus_tag="R751p47" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440" /db_xref="CDD:100107" misc_feature order(31233..31244,31287..31292,31353..31361,31413..31415) /gene="upf31.0" /locus_tag="R751p47" /note="S-adenosylmethionine binding site [chemical binding]; other site" /db_xref="CDD:100107" misc_feature <31389..31646 /gene="upf31.0" /locus_tag="R751p47" /note="Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338" /db_xref="CDD:223415" misc_feature 31709..39108 /note="similar to Xanthomonas sp. Tn5053: GenBank Accession Number L40585" gene complement(31911..32924) /gene="int" /locus_tag="R751p48" /db_xref="GeneID:877440" CDS complement(31911..32924) /gene="int" /locus_tag="R751p48" /function="integrase for integration of cassettes with 59bp element" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044257.1" /db_xref="GI:10955228" /db_xref="GeneID:877440" /translation="MKTATAPLPPLRSVKVLDQLRERIRYLHYSLRTEQAYVNWVRAF IRFHGVRHPATLGSSEVEAFLSWLANERKVSVSTHRQALAALLFFYGKVLCTDLPWLQ EIGRPRPSRRLPVVLTPDEVVRILGFLEGEHRLFAQLLYGTGMRISEGLQLRVKDLDF DHGTIIVREGKGSKDRALMLPESLAPSLREQLSRARAWWLKDQAEGRSGVALPDALER KYPRAGHSWPWFWVFAQHTHSTDPRSGVVRRHHMYDQTFQRAFKRAVEQAGITKPATP HTLRHSFATALLRSGYDIRTVQDLLGHSDVSTTMIYTHVLKVGGAGVRSPLDALPPLT SER" misc_feature complement(31920..32924) /gene="int" /locus_tag="R751p48" /note="integrase/recombinase; Provisional; Region: PRK15417" /db_xref="CDD:185315" misc_feature complement(31980..32786) /gene="int" /locus_tag="R751p48" /note="IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193" /db_xref="CDD:238598" misc_feature complement(order(31989..31991,32016..32018,32085..32087, 32094..32096,32412..32414,32487..32489)) /gene="int" /locus_tag="R751p48" /note="Int/Topo IB signature motif; other site" /db_xref="CDD:238598" gene 32809..33365 /gene="dhfrIIc" /locus_tag="R751p49" /db_xref="GeneID:877493" -35_signal 32809..32814 /gene="dhfrIIc" /locus_tag="R751p49" -10_signal 32832..32837 /gene="dhfrIIc" /locus_tag="R751p49" RBS 33120..33122 /gene="dhfrIIc" /locus_tag="R751p49" CDS 33129..33365 /gene="dhfrIIc" /locus_tag="R751p49" /function="trimethoprim resistant dihydrofolate reductase" /codon_start=1 /transl_table=11 /product="DhfrIIc" /protein_id="NP_044258.1" /db_xref="GI:10955229" /db_xref="GeneID:877493" /translation="MDQHNNGVSTLVAGQFALPSHATFGLGDRVRKKSGAAWQGQVVG WYCTKLTPEGYAVESESHPGSVQIYPVAALERVA" misc_feature 33129..33362 /gene="dhfrIIc" /locus_tag="R751p49" /note="R67 dihydrofolate reductase; Region: DHFR_2; pfam06442" /db_xref="CDD:115119" gene 33502..33792 /locus_tag="R751p50" /db_xref="GeneID:3251118" CDS 33502..33792 /locus_tag="R751p50" /function="unknown" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044259.1" /db_xref="GI:10955230" /db_xref="GeneID:3251118" /translation="MFIQTAFSFSNAVQRWVCRFSGLRLVALRWFVVFLASGPCVASA SSYFFRSAVPPRWHRAFSQLAPVAKLRLSVLASGSNISVKPTRILRSAYLAR" misc_feature 33511..33789 /locus_tag="R751p50" /note="Protein of unknown function (DUF1010); Region: DUF1010; pfam06231" /db_xref="CDD:114923" gene 33886..34229 /gene="qacE" /locus_tag="R751p51" /db_xref="GeneID:877489" RBS 33886..33889 /gene="qacE" /locus_tag="R751p51" CDS 33897..34229 /gene="qacE" /locus_tag="R751p51" /function="resistance to bacteriocidal quarternary ammonium compounds, multidrug exporter" /codon_start=1 /transl_table=11 /product="QacE" /protein_id="NP_044260.1" /db_xref="GI:10955231" /db_xref="GeneID:877489" /translation="MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAF YFLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIVSGVVVLN LLSKASAH" misc_feature 33897..34214 /gene="qacE" /locus_tag="R751p51" /note="Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076" /db_xref="CDD:224987" gene complement(34478..35111) /gene="tniC" /locus_tag="R751p52" /db_xref="GeneID:877490" CDS complement(34478..35101) /gene="tniC" /locus_tag="R751p52" /function="transposition" /codon_start=1 /transl_table=11 /product="TniC" /protein_id="NP_044261.1" /db_xref="GI:10955232" /db_xref="GeneID:877490" /translation="MLIGYMRVSKADGSQSTNLQRDALIAAGVSLAHLYEDLASGRRD DRPGLAACLKALREGDTLIVWKLDRLGRDLRHLINTVHDLTARSVGLKVLTGHGAAVD TTTAAGKLVFGIFAALAEFERELISERTVAGLISARARGRKGGRPFKMTAAKLRLAMA SMGQPETKVGDLCEELGITRQTLYRHVSPKGELRPDGVKLLSLGSAA" misc_feature complement(34523..35101) /gene="tniC" /locus_tag="R751p52" /note="multiple promoter invertase; Provisional; Region: mpi; PRK13413" /db_xref="CDD:184041" misc_feature complement(34703..35098) /gene="tniC" /locus_tag="R751p52" /note="Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768" /db_xref="CDD:239737" misc_feature complement(order(34886..34888,34895..34900,35075..35077, 35081..35083)) /gene="tniC" /locus_tag="R751p52" /note="catalytic residues [active]" /db_xref="CDD:239737" misc_feature complement(35075..35077) /gene="tniC" /locus_tag="R751p52" /note="catalytic nucleophile [active]" /db_xref="CDD:239737" misc_feature complement(order(34736..34738,34748..34753,34757..34762, 34901..34903)) /gene="tniC" /locus_tag="R751p52" /note="Presynaptic Site I dimer interface [polypeptide binding]; other site" /db_xref="CDD:239737" misc_feature complement(order(34730..34732,34739..34741,34748..34753, 34760..34765,34772..34774,34865..34870,34883..34885)) /gene="tniC" /locus_tag="R751p52" /note="Synaptic Antiparallel dimer interface [polypeptide binding]; other site" /db_xref="CDD:239737" misc_feature complement(order(34715..34717,34727..34729,34736..34738, 34748..34750,34757..34762,34769..34774,34799..34804, 34814..34816)) /gene="tniC" /locus_tag="R751p52" /note="Synaptic Flat tetramer interface [polypeptide binding]; other site" /db_xref="CDD:239737" misc_feature complement(order(34715..34717,34727..34729,34736..34738, 34748..34750,34757..34759,34814..34816)) /gene="tniC" /locus_tag="R751p52" /note="Synaptic Site I dimer interface [polypeptide binding]; other site" /db_xref="CDD:239737" misc_feature complement(order(34712..34717,34733..34735)) /gene="tniC" /locus_tag="R751p52" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:239737" misc_feature complement(34541..34669) /gene="tniC" /locus_tag="R751p52" /note="Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569" /db_xref="CDD:259851" misc_feature complement(order(34544..34552,34556..34561,34658..34666)) /gene="tniC" /locus_tag="R751p52" /note="DNA-binding interface [nucleotide binding]; DNA binding site" /db_xref="CDD:259851" RBS complement(35107..35111) /gene="tniC" /locus_tag="R751p52" gene complement(35163..36380) /locus_tag="R751p53" /db_xref="GeneID:877467" CDS complement(35163..36380) /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044262.1" /db_xref="GI:10955233" /translation="MKPAPRWPLHPAPKEGEALSSWLNRVALCYHMEEPDLLEHDLGH GQVDDLDTAPPLSLLALLSQRSGIELDRLRCMSFAGWVPWLLDSLDDQIPDALETYAF QLSVLLPRLRRKTRSITSWRAWLPSQPINRACPLCLSDPENQAVLLAWKLPLMLSCPL HGCWLESYWGVPGRFLGWENADAEPRTASDAIAAMDQRTWQALTTGHVELPRRRIHAG LWFRLLRTLLDELNTPLSACGTCAGYPRQVWEGCGHPLRAGQSLWRPYETLNPIVRLQ MLEAAATAISLIEVRDISPPGEQAKLFWSEPQTGFTSGLPTKAPKPEPINHWQRAVQA IDEAIIEARHNPETARSLFALASYGRRDPASLERLRATFVKEGIPPEFLSHYLPDAPF ACLKQNDGLSDKF" misc_feature complement(35886..36365) /note="TniQ; Region: TniQ; pfam06527" /db_xref="CDD:253782" gene complement(36377..37299) /gene="tniB" /locus_tag="R751p54" /db_xref="GeneID:877488" CDS complement(36377..37285) /gene="tniB" /locus_tag="R751p54" /function="transposition" /codon_start=1 /transl_table=11 /product="TniB" /protein_id="NP_044263.1" /db_xref="GI:10955234" /db_xref="GeneID:877488" /translation="MDEYPIIDLSHLLPAAQGLARLPADERIQRLRADRWIGYPRAVE ALNRLEALYAWPNKQRMPNLLLVGPTNNGKSMIVEKFRRTHPASSDADQEHIPVLVVQ MPSEPSVIRFYVALLAAMGAPLRPRPRLPEMEQLALALLRKVGVRMLVIDELHNVLAG NSVNRREFLNLLRFLGNELRIPLVGVGTRDAYLAIRSDDQLENRFEPMMLPVWEANDD CCSLLASFAASLPLRRPSPIATLDMARYLLTRSEGTIGELAHLLMAAAIVAVESGEEA INHRTLSMAVYTGPSERRRQFERELM" misc_feature complement(36380..37285) /gene="tniB" /locus_tag="R751p54" /note="Bacterial TniB protein; Region: TniB; pfam05621" /db_xref="CDD:203290" RBS complement(36387..36390) /note="note=orf6" gene complement(37288..39060) /gene="tniA" /locus_tag="R751p55" /db_xref="GeneID:3251119" CDS complement(37288..38967) /gene="tniA" /locus_tag="R751p55" /function="transposition" /codon_start=1 /transl_table=11 /product="TniA" /protein_id="NP_044264.1" /db_xref="GI:10955235" /db_xref="GeneID:3251119" /translation="MATDTPRIPEQGVATLPDEAWERARRRAEIISPLAQSETVGHEA ADMAAQALGLSRRQVYVLIRRARQGSGLVTDLVPGQSGGGKGKGRLPEPVERVIHELL QKRFLTKQKRSLAAFHREVTQVCKAQKLRVPARNTVALRIASLDPRKVIRRREGQDAA RDLQGVGGEPPAVTAPLEQVQIDHTVIDLIVVDDRDRQPIGRPYLTLAIDVFTRCVLG MVVTLEAPSAVSVGLCLVHVACDKRPWLEGLNVEMDWQMSGKPLLLYLDNAAEFKSEA LRRGCEQHGIRLDYRPLGQPHYGGIVERIIGTAMQMIHDELPGTTFSNPDQRGDYDSE NKAALTLRELERWLTLAVGTYHGSVHNGLLQPPAARWAEAVARVGVPAVVTRATSFLV DFLPILRRTLTRTGFVIDHIHYYADALKPWIARRERWPSFLIRRDPRDISRIWVLEPE GQHYLEIPYRTLSHPAVTLWEQRQALAKLRQQGREQVDESALFRMIGQMREIVTSAQK ATRKARRDADRRQHLKTSARPDKPVPPDTDIADPQADNLPPAKPFDQIEEW" misc_feature complement(38029..38442) /gene="tniA" /locus_tag="R751p55" /note="Integrase core domain; Region: rve; pfam00665" /db_xref="CDD:216050" misc_feature complement(37606..37800) /gene="tniA" /locus_tag="R751p55" /note="Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299" /db_xref="CDD:220169" RBS complement(37296..37299) /gene="tniB" /locus_tag="R751p54" RBS complement(38973..38976) /gene="tniA" /locus_tag="R751p55" -10_signal complement(39033..39038) /gene="tniA" /locus_tag="R751p55" -35_signal complement(39055..39060) /gene="tniA" /locus_tag="R751p55" repeat_region 39083..39107 /note="similar to Tn402" /rpt_type=inverted repeat_region 39202..39221 /note="belongs to family of inverted repeats in oriV-trfA and tra1-tra2 gaps" /rpt_type=direct repeat_region 39256..39337 /note="belongs to family of inverted repeats in oriV-trfA and tra1-tra2 gaps" /rpt_type=direct repeat_region 39296..39315 /note="belongs to family of inverted repeats in oriV-trfA and tra1-tra2 gaps" /rpt_type=direct repeat_region 39350..39369 /note="belongs to a family of inverted repeats in oriV-trfA and tra1-tra2 gaps" /rpt_type=direct terminator complement(39383..39413) /note="transcriptional terminator following traC" gene complement(39518..43877) /gene="traC-2" /locus_tag="R751p56" /db_xref="GeneID:877491" CDS complement(39518..43864) /gene="traC-2" /locus_tag="R751p56" /function="primase" /codon_start=1 /transl_table=11 /product="TraC2" /protein_id="NP_044265.1" /db_xref="GI:10955236" /db_xref="GeneID:877491" /translation="MPITKAEAQGVTRAFVRDYPGALELAYKFREDAAELYGPRAAEV PADMKGGYVPKETLHAGRAYRGRVDVPLQNVESASDLLMTLRHEVLGHYGANTFAPGE KRALLDGLAAARNEPTLKPLWDDVNRRYAGQSLDVRAEEVFALHCEGIEPSQHQVADQ VQQRGQQSFTETCIARVRPMQADDLHNIVCMVAQGLRDRSRTQQNFPQFNELFRRDEN MEPKKPFHEVVAEKLIEQLKAGTAPWQKPWEPGEPNAYLPMNPTTGKRYKGINAIHLM AQGRSDARWMTYKQAAAVGAQVRKGEKGTPVQYWKFSEEQDKLDDSGRPVLDAKGQPV KETVMLERPRVFFATVFNGEQIDGLPPLQPKKEQTWNAVERAEHILKASGATITHAAG DRAFYRPSTDSITLPERGQFPSSDRYYATALHELGHWTGHASRLDRDLAHPFGSEGYA KEELRAEIASMIVGDELGIGHDPGQHAAYVGSWIKALQDEPLEVFRAAADAEKIHDYV LAFEQKQVQEQDQQQSQAQDEAVAQALAVDIAEVLDNPDVSFSHYQAFQGDTLEDALR SRGLETVGSITGTDPEQFYAVAHDRLSPVFGIDPSHTDTDNAYLERKGLAQEFANMAE QLHLAQQLQQHGEQIVSSIDAEARWSDGQRIFAFHDQDGEPHQVRSLDELNNYAPDQL MALPALTQQQAAVADQEANMTPPTIDQAAALLAAHPADAVQGIEQAAAARRQLAAGEI DGQAFADATRQHLGVELPPDWSGELRIVGVAEQDGQTVDAAQAGIEPQAFQVYARKAD AQFGEDAFAFVAGTRTEGQAEALAERLHLVDALGTDNQHERAAKLARVQEERVRRDPN ATEEDISAAKEARKTAEASAMLNDSDAQRRAAELERQERDRQQAQPQAEKPERQYINV PYKEKDEAKSLGARWDRQQQSWYVPPGTDAAPFAKWAQGAATAAVEPRSAQPAPEAQG EAQKPAQQAQQARQYLAVPYEQRNAAKAAGALWDKAAKSWYVGPRADAAKLERWKPEN VQAQQGPAMTPREEFAEAMRSAGLFTGSNAQGDHPIMDGKRHRVPVEGGKKGALDGFY VGHLDGHPAGRIINNKTGTDITWKSKGYALSDQEKAKLQAEAAEKLAQRAVEQDKAQE ATAQRVGRQMADLVPIEQPTPYLQAKGIQAQAGVMTDREGQKTYIPAFDAEGKQWTMQ YIQEDGTKRFAKDSKKEGCFHPVGGMDALAAAPALVISEGYATAAQVAEAVGHATVAA FDSGNLEAVAKALHAKFPDKPVIIAGDDDRHLVMTHGNNPGREKAEAAAQAVGGKAIF PIFAPAENTYPRDLPAITPDSFKTHLRAEQRLADAAAGKVELAGDEAAKLKASMLSGA QIAALSTMKQHTDFNDLAHKSELGIEGVKRQIGAAISQVQRDEQQHQEQKHVEKKQQQ IEQRPRRAARIG" misc_feature complement(42329..43222) /gene="traC-2" /locus_tag="R751p56" /note="Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227" /db_xref="CDD:226680" misc_feature complement(42827..43201) /gene="traC-2" /locus_tag="R751p56" /note="Domain of unknown function (DUF1738); Region: DUF1738; pfam08401" /db_xref="CDD:254778" misc_feature complement(39881..40774) /gene="traC-2" /locus_tag="R751p56" /note="Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643" /db_xref="CDD:226990" misc_feature complement(39896..40150) /gene="traC-2" /locus_tag="R751p56" /note="TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029" /db_xref="CDD:173779" misc_feature complement(order(39968..39970,39992..39994,39998..40000, 40124..40126,40133..40138)) /gene="traC-2" /locus_tag="R751p56" /note="active site" /db_xref="CDD:173779" misc_feature complement(order(39998..40000,40136..40138)) /gene="traC-2" /locus_tag="R751p56" /note="metal binding site [ion binding]; metal-binding site" /db_xref="CDD:173779" misc_feature complement(order(40076..40078,40106..40111,40127..40132)) /gene="traC-2" /locus_tag="R751p56" /note="interdomain interaction site; other site" /db_xref="CDD:173779" gene complement(39518..43223) /gene="traC-3" /locus_tag="R751p57" /db_xref="GeneID:877470" CDS complement(39518..43210) /gene="traC-3" /locus_tag="R751p57" /function="primase" /codon_start=1 /transl_table=11 /product="TraC3" /protein_id="NP_044266.1" /db_xref="GI:10955238" /db_xref="GeneID:877470" /translation="MEPKKPFHEVVAEKLIEQLKAGTAPWQKPWEPGEPNAYLPMNPT TGKRYKGINAIHLMAQGRSDARWMTYKQAAAVGAQVRKGEKGTPVQYWKFSEEQDKLD DSGRPVLDAKGQPVKETVMLERPRVFFATVFNGEQIDGLPPLQPKKEQTWNAVERAEH ILKASGATITHAAGDRAFYRPSTDSITLPERGQFPSSDRYYATALHELGHWTGHASRL DRDLAHPFGSEGYAKEELRAEIASMIVGDELGIGHDPGQHAAYVGSWIKALQDEPLEV FRAAADAEKIHDYVLAFEQKQVQEQDQQQSQAQDEAVAQALAVDIAEVLDNPDVSFSH YQAFQGDTLEDALRSRGLETVGSITGTDPEQFYAVAHDRLSPVFGIDPSHTDTDNAYL ERKGLAQEFANMAEQLHLAQQLQQHGEQIVSSIDAEARWSDGQRIFAFHDQDGEPHQV RSLDELNNYAPDQLMALPALTQQQAAVADQEANMTPPTIDQAAALLAAHPADAVQGIE QAAAARRQLAAGEIDGQAFADATRQHLGVELPPDWSGELRIVGVAEQDGQTVDAAQAG IEPQAFQVYARKADAQFGEDAFAFVAGTRTEGQAEALAERLHLVDALGTDNQHERAAK LARVQEERVRRDPNATEEDISAAKEARKTAEASAMLNDSDAQRRAAELERQERDRQQA QPQAEKPERQYINVPYKEKDEAKSLGARWDRQQQSWYVPPGTDAAPFAKWAQGAATAA VEPRSAQPAPEAQGEAQKPAQQAQQARQYLAVPYEQRNAAKAAGALWDKAAKSWYVGP RADAAKLERWKPENVQAQQGPAMTPREEFAEAMRSAGLFTGSNAQGDHPIMDGKRHRV PVEGGKKGALDGFYVGHLDGHPAGRIINNKTGTDITWKSKGYALSDQEKAKLQAEAAE KLAQRAVEQDKAQEATAQRVGRQMADLVPIEQPTPYLQAKGIQAQAGVMTDREGQKTY IPAFDAEGKQWTMQYIQEDGTKRFAKDSKKEGCFHPVGGMDALAAAPALVISEGYATA AQVAEAVGHATVAAFDSGNLEAVAKALHAKFPDKPVIIAGDDDRHLVMTHGNNPGREK AEAAAQAVGGKAIFPIFAPAENTYPRDLPAITPDSFKTHLRAEQRLADAAAGKVELAG DEAAKLKASMLSGAQIAALSTMKQHTDFNDLAHKSELGIEGVKRQIGAAISQVQRDEQ QHQEQKHVEKKQQQIEQRPRRAARIG" misc_feature complement(42329..43204) /gene="traC-3" /locus_tag="R751p57" /note="Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227" /db_xref="CDD:226680" misc_feature complement(42827..43201) /gene="traC-3" /locus_tag="R751p57" /note="Domain of unknown function (DUF1738); Region: DUF1738; pfam08401" /db_xref="CDD:254778" misc_feature complement(39881..40774) /gene="traC-3" /locus_tag="R751p57" /note="Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643" /db_xref="CDD:226990" misc_feature complement(39896..40150) /gene="traC-3" /locus_tag="R751p57" /note="TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029" /db_xref="CDD:173779" misc_feature complement(order(39968..39970,39992..39994,39998..40000, 40124..40126,40133..40138)) /gene="traC-3" /locus_tag="R751p57" /note="active site" /db_xref="CDD:173779" misc_feature complement(order(39998..40000,40136..40138)) /gene="traC-3" /locus_tag="R751p57" /note="metal binding site [ion binding]; metal-binding site" /db_xref="CDD:173779" misc_feature complement(order(40076..40078,40106..40111,40127..40132)) /gene="traC-3" /locus_tag="R751p57" /note="interdomain interaction site; other site" /db_xref="CDD:173779" RBS complement(41767..41772) /gene="traC-3" /locus_tag="R751p57" RBS complement(43220..43223) /gene="traC-3" /locus_tag="R751p57" gene complement(43868..44269) /gene="traD" /locus_tag="R751p59" /db_xref="GeneID:877435" CDS complement(43868..44257) /gene="traD" /locus_tag="R751p59" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044268.1" /db_xref="GI:10955239" /db_xref="GeneID:877435" /translation="MNEQTTTNTAAHDEPLAVLPPVDDDAAGREAVREKMADALTPGF QVEFDPDEAERVGAFVEDALSEQDAAASGDDLVEVDGALEPAFLDDEGPSADIPPFIT TTNARELYDLRPGETVAQAAARKASEG" RBS complement(43873..43877) /gene="traC-2" /locus_tag="R751p56" RBS complement(44265..44269) /gene="traD" /locus_tag="R751p59" gene complement(44279..46353) /gene="traE" /locus_tag="R751p60" /db_xref="GeneID:877471" CDS complement(44279..46342) /gene="traE" /locus_tag="R751p60" /function="possible helicase" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044269.1" /db_xref="GI:10955240" /db_xref="GeneID:877471" /translation="MRLFIAEKPSVAKAIAGELGATGKGDGFIECGTDKVTWCFGHML EQADPDEYTPDDVPRGQSGKKVWRVDELPIIPESWILKPKDDAKKQLAVIGKLLKEAK EIVNAGDPDREGQLLVDEVLEHFRNSKPVRRFWVSAQDSVSVKRGLAALKENTTYAGW ADAARGRQRADWLIGMNLSRAYTLRAQRGGSRALLTVGRVQTPTLALVVARDREIEAF KAVPYHTIRAVVQHAGGSFAAAWKAKEDQAGLYSEGRLVDTAVADALVAAVKGQPGTI AAYKQEAKKQNQPLAFALSDITALASAKFGYSAEDVLNTCQALYETHKLTCTRAPTAP TCRSRSTPTRRACWRRSSTSTPTGRPGRWCRSAYQVQDVGRLEDHRAPRHRADHAEGQ QGRPQRARAQHLRPDRARLPGAVLPAARVHADHRGRSRFAGENFAASGKVVTRNGWRD VYSQADEEGEKDEDDDSGTQALPSMAQGDAVTCTDATRKDAKTKPPARFTEGTLIRAM ENIHKFVSDAEHKKMLREGDGIGTSATRASIISELKRREFLAVKGKQIISTTLGRSVI DALPEVVKSPVLTALYERMLKGVEQGTAALDAFITKQETFIRDQVAKANSGAVTIAGG KEAAPVSSLHKCMACGSGLSRRPSKKKGQFWWGCSNFPTCKQTYPDLKGRPDYSKGRN GQASE" misc_feature complement(45890..46342) /gene="traE" /locus_tag="R751p60" /note="TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362" /db_xref="CDD:173782" misc_feature complement(order(46004..46006,46010..46012,46016..46018, 46310..46312,46319..46324)) /gene="traE" /locus_tag="R751p60" /note="active site" /db_xref="CDD:173782" misc_feature complement(order(45974..45979,45983..45988,46007..46009, 46013..46015,46301..46303)) /gene="traE" /locus_tag="R751p60" /note="putative interdomain interaction site [polypeptide binding]; other site" /db_xref="CDD:173782" misc_feature complement(order(46010..46012,46016..46018)) /gene="traE" /locus_tag="R751p60" /note="putative metal-binding site [ion binding]; other site" /db_xref="CDD:173782" misc_feature complement(46007..46009) /gene="traE" /locus_tag="R751p60" /note="putative nucleotide binding site [chemical binding]; other site" /db_xref="CDD:173782" misc_feature complement(<45365..45868) /gene="traE" /locus_tag="R751p60" /note="DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986" /db_xref="CDD:245827" misc_feature complement(order(45698..45760,45788..45868)) /gene="traE" /locus_tag="R751p60" /note="domain I; other site" /db_xref="CDD:238110" misc_feature complement(order(45713..45715,45725..45727)) /gene="traE" /locus_tag="R751p60" /note="phosphate binding site [ion binding]; other site" /db_xref="CDD:238110" misc_feature complement(44510..>45049) /gene="traE" /locus_tag="R751p60" /note="DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986" /db_xref="CDD:245827" misc_feature complement(order(44510..44626,44633..44677,44687..44758, 44810..44860)) /gene="traE" /locus_tag="R751p60" /note="domain IV; other site" /db_xref="CDD:238110" misc_feature complement(44327..44440) /gene="traE" /locus_tag="R751p60" /note="Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396" /db_xref="CDD:110400" RBS complement(46350..46353) /gene="traE" /locus_tag="R751p60" gene complement(46354..46905) /gene="traF" /locus_tag="R751p61" /db_xref="GeneID:877457" CDS complement(46354..46890) /gene="traF" /locus_tag="R751p61" /function="mpf during conjugation" /codon_start=1 /transl_table=11 /product="conjugal transfer peptidase TraF" /protein_id="NP_044270.1" /db_xref="GI:10955241" /db_xref="GeneID:877457" /translation="MSRILKRIAAGVVIAGVAALLLAAGGYAAGARVNTTKSIPVGLY WTSSAPVEKGAYVLFCPPQLGVFDDAKERGYIGAGFCQGGYGYMMKRVLAAKDDAVAV ADDGVRVNGELLPLSAPIKADKAGRPLPRYQSNSYTLGNSEVLLMSDVSATSFDGRYF GPINRSQIKTVIRPVITW" misc_feature complement(46357..46890) /gene="traF" /locus_tag="R751p61" /note="conjugal transfer peptidase TraF; Provisional; Region: PRK13884" /db_xref="CDD:184368" misc_feature complement(46357..46797) /gene="traF" /locus_tag="R751p61" /note="conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838" /db_xref="CDD:172365" protein_bind complement(46603..46615) /bound_moiety="KorB" gene complement(46887..48808) /gene="traG" /locus_tag="R751p62" /db_xref="GeneID:877464" CDS complement(46887..48800) /gene="traG" /locus_tag="R751p62" /function="unknown" /note="type IV secretion system VirD4 family" /codon_start=1 /transl_table=11 /product="conjugal transfer coupling protein TraG" /protein_id="NP_044271.1" /db_xref="GI:10955242" /db_xref="GeneID:877464" /translation="MKIKMNNAVGPQVRTAKPKPSKLLPVLGAASMVGGLQAATQFFA HTFAYHATLGPNVGHVYAPWSILHWTYKWYSQYPDEIMKAGSMGMLVSTVGLLGVAVA KVVTSNSSKANEYLHGSARWAEKKDIQAAGLLPRERNVLEIVTGKAAPTATGVYVGGW QDKDGNFFYLRHSGPEHVLTYAPTRSGKGVGLVVPTLLSWGASSVITDLKGELWALTA GWRQKHAKNKVLRFEPASTSGGVCWNPLDEIRLGTEYEVGDVQNLATLIVDPDGKGLD SHWQKTAFALLVGVILHALYKAKDDGGTATLPSVDAMLADPNRDIGELWMEMATYGHV DGQNHHAIGSAARDMMDRPEEEAGSVLSTAKSYLALYRDPVVARNVSRSDFRIKQLMH EDDPVSLYIVTQPNDKARLRPLVRVMVNMIVRLLADKMDFEGGRPVAHYKHRLLMMLD EFPSLGKLEIMQESLAFVAGYGIKCYLICQDINQLKSRETGYGHDESITSNCHVQNAY PPNRVETAEHLSRLTGQTTVVKEQITTSGRRTAAMLGQVSRTYQEVQRPLLTPDECLR MPGPKKNAQGEIEEAGDMVIYVAGYPAIYGKQPLYFKDPVFSARAAIPAPKVSDRLRA VAQADTEGEGITI" misc_feature complement(46890..48800) /gene="traG" /locus_tag="R751p62" /note="conjugal transfer coupling protein TraG; Provisional; Region: PRK13880" /db_xref="CDD:237540" misc_feature complement(47100..48272) /gene="traG" /locus_tag="R751p62" /note="RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233" /db_xref="CDD:266574" misc_feature complement(order(48234..48242,48252..48257)) /gene="traG" /locus_tag="R751p62" /note="Walker A motif; other site" /db_xref="CDD:238540" misc_feature complement(order(47448..47453,48174..48179,48183..48185, 48234..48242,48252..48254)) /gene="traG" /locus_tag="R751p62" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:238540" misc_feature complement(47451..47465) /gene="traG" /locus_tag="R751p62" /note="Walker B motif; other site" /db_xref="CDD:238540" RBS complement(46901..46905) /gene="traF" /locus_tag="R751p61" gene complement(48797..51040) /gene="traI" /locus_tag="R751p63" /db_xref="GeneID:877494" CDS complement(48797..51040) /gene="traI" /locus_tag="R751p63" /function="DNA relaxase" /codon_start=1 /transl_table=11 /product="conjugal transfer relaxase TraI" /protein_id="NP_044272.1" /db_xref="GI:10955243" /db_xref="GeneID:877494" /translation="MIAKHVPMRSLGKSDFAGLANYITDAQSKDHRLGHVQATNCEAG SIQDAITEVLATQHTNTRAKGDKTYHLIVSFRAGEQPSADTLRAIEERICVGLGYGEH QRISAVHNDTDNLHIHIAINKIHPTRHTMHEPYYPHRALAELCTALERDYGLERDNHE PRKRGAEGRAADMERHAGVESLVGWIKRECLDEIKGAQSWQELHQVMRDNGMELRVRA NGLVFEAGDGTMVKASTVARDLSKPSLEARLGPFEASPERQAQTTAKRQYRKDPIRLR VNTVELYAKYKAEQQSLTTARAQALERARHRKDRLIEAAKRSNRLRRATIKVVGEGRA NKKLLYAQASKALRSEIQAINKQFQQERTALYAEHSRRTWADWLKKEAQHGGADALAA LRAREAAQGLKGNTIRGEGQAKPGHAPAVDNITKKGTIIFRAGMSAVRDDGDRLQVSR EATREGLQEALRLAMQRYGNRITVNGTVEFKAQMIRAAVDSQLPITFTDPALESRRQA LLNKENTHERTERPEHRGRTGRGAGGPGQRPAADQHATGAAAVARAGDGRPAAGRGDR ADAGLHAATVHRKPDVGRLGRKPPPQSQHRLRALSELGVVRIAGGSEVLLPRDVPRHV EQQGTQPDHALRRGISRPGTGVGQTPPGVAAADKYIAEREAKRLKGFDIPKHSRYTAG DGALTFQGTRTIEGQALALLKRGDEVMVMPIDQATARRLTRIAVGRDAVSITAKGSIK TSKGRSR" misc_feature complement(48800..51040) /gene="traI" /locus_tag="R751p63" /note="conjugal transfer relaxase TraI; Provisional; Region: PRK13878" /db_xref="CDD:237539" RBS complement(48804..48808) /gene="traG" /locus_tag="R751p62" gene complement(49102..49506) /gene="traH" /locus_tag="R751p64" /db_xref="GeneID:877473" CDS complement(49102..49494) /gene="traH" /locus_tag="R751p64" /function="relaxosome stabilisation" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044273.1" /db_xref="GI:10955244" /db_xref="GeneID:877473" /translation="MSEPKDQSIEDELDAALAALDSGPLPTSTLPEPQPSPEQATAGQ PPAEATAPTPAFTPPPSTGSPTLDALEENRRPKASTVCEHCPNSVWFASPAEVKCYCR VMFLVTWSSKEPNQITHCDGEFLGQEQE" RBS complement(49502..49506) /gene="traH" /locus_tag="R751p64" gene complement(51075..51663) /gene="traJ" /locus_tag="R751p66" /db_xref="GeneID:877474" CDS complement(51075..51449) /gene="traJ" /locus_tag="R751p66" /function="oriT recognizing protein" /codon_start=1 /transl_table=11 /product="conjugal transfer relaxosome component TraJ" /protein_id="NP_044275.2" /db_xref="GI:62765884" /db_xref="GeneID:877474" /translation="MENDEKEHGRRRRQHLRVPVFPEEKDEIEANAKRAGVSVARYLR DVGQGYQIKGVMDYQHVRELVRVNGDLGRLGGLLKLWLTDDVRTLQFGEATILALLGR IEATQDEMSRIMKAVVQPRAEP" misc_feature complement(51099..51440) /gene="traJ" /locus_tag="R751p66" /note="conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877" /db_xref="CDD:184361" RBS complement(51087..51090) /note="ORFX" RBS complement(51456..51459) /gene="traJ" /locus_tag="R751p66" misc_feature 51526..51624 /note="relaxation region" repeat_region 51538..51577 /rpt_type=inverted misc_feature 51563..51663 /note="palindrome" misc_feature 51585..51586 /note="nic site" -10_signal complement(51631..51636) /gene="traJ" /locus_tag="R751p66" -35_signal complement(51658..51663) /gene="traJ" /locus_tag="R751p66" gene 51686..52221 /gene="traK" /locus_tag="R751p67" /db_xref="GeneID:3251120" -35_signal 51686..51691 /gene="traK" /locus_tag="R751p67" -10_signal 51709..51714 /gene="traK" /locus_tag="R751p67" RBS 51712..51716 /gene="traK" /locus_tag="R751p67" CDS 51823..52221 /gene="traK" /locus_tag="R751p67" /function="oriT-binding protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_044276.1" /db_xref="GI:10955247" /db_xref="GeneID:3251120" /translation="MPKTYPEELAEWVKGREAKKPRQDKHVVAFLAVKSDVQAALDAG YAMKTIWEHMKETGRLRCRYETFTQHVKRYIKAAPVASPPPPATPPDSQPKGAKPEPK AAPPASESKSEPPKIGGFTFDATPKKEDLL" gene 52204..52946 /gene="traL" /locus_tag="R751p68" /db_xref="GeneID:877452" RBS 52204..52211 /gene="traL" /locus_tag="R751p68" CDS 52221..52946 /gene="traL" /locus_tag="R751p68" /function="essential transfer protein" /codon_start=1 /transl_table=11 /product="conjugal transfer protein TraL" /protein_id="NP_044277.1" /db_xref="GI:10955248" /db_xref="GeneID:877452" /translation="MAKIHMVLQGKGGVGKSMIAATIAQYKAGKGQKPLCIDTDPVNA TFEGYKALNVRRLNIMDGDDINTRNFDALVEMIASAEGDVIIDNGASSFVPLSHYLIS NQVPALLQDMGHELVVHTVVTGGQALVDTVSGFAQLASQFPAECLFVVWLNPYWGPIE HEGKGFEQLKAYTANKGRVSAIIQIPALKEETYGRDFAEMLQDRRTFDEALADSALTI MTRQRLKIVKTQLFAQLENAAVL" misc_feature 52233..52679 /gene="traL" /locus_tag="R751p68" /note="The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034" /db_xref="CDD:238991" misc_feature 52248..52271 /gene="traL" /locus_tag="R751p68" /note="P-loop; other site" /db_xref="CDD:238991" gene 52934..53386 /gene="traM" /locus_tag="R751p69" /db_xref="GeneID:877492" RBS 52934..52939 /gene="traM" /locus_tag="R751p69" CDS 52946..53386 /gene="traM" /locus_tag="R751p69" /function="essential transfer protein" /codon_start=1 /transl_table=11 /product="conjugal transfer protein TraM" /protein_id="NP_044278.1" /db_xref="GI:10955249" /db_xref="GeneID:877492" /translation="MAADDKIEELIREIAAKHGIAVGRDDPILILQTINMKLMQDSAS AQQEILDAFKSELESIAHRWGDDAKGKAERTLNAALAASKDAMTRGMQEGAKAAAEAV RREVEAVTAQLVAPIREARRVAMMNMVAAGMAVVAAGLALWASL" misc_feature 52955..53302 /gene="traM" /locus_tag="R751p69" /note="conjugal transfer protein TraM; Provisional; Region: PRK13895" /db_xref="CDD:184378" CONTIG join(U67194.4:1..53423) ORIGIN 1 gtcgaccgcg ccggcggcat cgccaggttc ggcgatgctg gccagctccc ggcatcgtcg 61 cttgcgacga tgctgcagga tgattcccgc caggccctcg gcgggctccc tcgccagaaa 121 tggcgatgct cgagaaaaaa gcccggcgac cgccgggctt cgtttttatg cgggcctggc 181 tgacaggccc aaggactgcg atctccctgg ccgctcctgg gcctgggatt gcttgcgctc 241 ctgctcctgc ttgcgcatca gcagctcatg ccggcgggcg gcctcgcgca tggcatccca 301 atcggaagcc agctcggggt tctcggcgcg catcttgcgc gtcgccagct cttcgatctt 361 cggcgagtgc aggcccatgc cttccttgat ctcgcggacg gcctccaggc gcgcgtgaag 421 cgtctgcaag cgggcctgct gctgcgcctg ctggttctgc caggctcgct tagagccggg 481 caaggaaagc cggccaggcg cggacgcctg ggtctgctgc aagcgggcct gctgccggtc 541 gatcaggttt tctagcctgt cctcgatgtg tccacctggt cgtgctctgg cctgcacgta 601 gagcgccagg gtttcggggt aggactgctc gaccggggcc gcctctaggg tggcctgctg 661 ctcgatctcg gccgcctggg cggcctccag caagtcggct ccggtgtcct cgcgcgaagc 721 gccgaaggcg gcaccgccga gggtggccgg cgcgctgacg cgggccggct tggtggcgcg 781 gctctcggtg ccgctgccgg ggatggtgag tcgtttcaag ggcgtgcctc ctttttagcc 841 gctaaagcta catggagcgc ccccgcgtca gtttcggggc ctctgcggcg actgccgcct 901 tgccctgggc gttgtagctg atgctctttg cgctcccaat ttcaggtact ttatcgaaat 961 ctgaccgagc gtgcatgaca aagttcttgc cgatctgctg gtacacgttg gtggcgtcgg 1021 catgaacgat cacgccggcg tgggtctgct tcttgtcggc cgcttgggcc gtgtacaggt 1081 tgtagatgcc gggcttcaac gcgcccgcct tgtctacttt ctgattcgtc caagcgccgt 1141 ccttttcggc ctgaacgatg cgttgaccgt tcatgaccaa gaggcgttgt ttcatcgggc 1201 actcctatgg ttgccgtggt tctcaaaagg gtgatggtgg ccccatgcaa gccgcgctcc 1261 aacaaaaaag ccgacctcgg caaagcgagg ccggctcttc ccagcggccg ggttgtgcgt 1321 tttgtcaggg ttccagggta attttaagga aaaccaaccg atttatcagg tctttttgcg 1381 tccgccgctg gtcggatcgg ccgcccggcc ttgcgccatg acggtttcca gggcctccag 1441 ccggccgcga agcccggccg cttcctcgcg ggcctgggca gcgtcgcgct tcgcctggtc 1501 gcgctcgccc tgggcggcgg tcagccgctc ggcctggcgg tgtgcctcgg ccgccatcgc 1561 cttgcgctgc tcctggtggg cctgctcggc cgcctcggcc ttggcctgca ccttcaccag 1621 ctccgcgcgc acctggtcgc gctcggcggc ggccacctcg gccttccgct gctcggcctg 1681 agcggcgcgc gcctggtcgg tcgcctggtt cgcccgctcc aggtcggcac gcagctcgcc 1741 ggcgcggcgc tcgatctcgg cggtacggct gttcgcggcc gcgaggtcgg cccgcagggc 1801 ctccacctgg tcggcgctgg ccgtggccct ctcctgggcc ttgtcgcgct ctgcgcgcgc 1861 ctggcgggct tcctgatggg cgtgatccag ctccgtgcgc agctcgccgg ccctggcctc 1921 ggccgtggcc gcgcgctcgc tggtcgccgc gagcttgccg cgcagctcgt cggcctcgcc 1981 cttggcggcc gcctcgacgg cctccagggc cgcgacgcgg gccttggcct cgtccagctc 2041 gccggtgagc tggtcggcca gctctgcggc ttcctggcgc gctgcttccg tctcctggcg 2101 cacggcctcc agcgcctcgc gctcggcggc caggcggttg ttcgccattt ccagcgccac 2161 ggcccacaag tcgccgccca gctcggccag cttgtcggtg atcgcctgcg gtgccggctc 2221 gcggatcggg gcggcctggc tggccttgcg tgcgcgccac tcgttcatcg cctcgctgat 2281 ggtggtgaag ctgccgctgc cgagctgctt gcgcacgttc gccagcgtgg ggttctggcc 2341 ggccgcgtcc agttcgtcgg ccaccgcaaa tatctgctcc ttcgagatcg ccatgtcggg 2401 cctcctttgg ccggttgtat gttgtagcgt gtagcatact acaacataca acactacgca 2461 agcggtttag ctgaactttt tttagcggct aaaacgcggg caaaaaaaag ccccgctcga 2521 tggcggggcg atgggtgggg gtcggtggtc ggcgatgccc ggcgctgggc gtgtcagccc 2581 tccagcagcg cgacaagctg cacggtgcca aggtcggcct cgaactcctg gccgtcatcc 2641 tcgtatttga gccaggccca gccctcggcc gggggccggc ggttgaggat cagccgtgcc 2701 ggccggtcgt cgtgcttgac ctgtatgatg gccttcttga gcttgtcggg gtcggcctcc 2761 ttcggctcct tcttcccctt ggcgtcatca tcctgcggcc cctgctcgcc gtcgccggcc 2821 tcggcgtcgg tcttgccggt cagcgcatcg acggtgttgg gatcacggtc gccgtcgtcg 2881 tgactgcgct tgtcctccag gaactcgcgc agcagcttca ccgagccgcg cgtcagctcc 2941 tggctgtcgt cggccagcca ggcggccacc tcgtcggggt tcttcttgta ggccgtcacc 3001 agctcgttga tgacagtcac gtccttgccc cggccgctat tgaacgcctc ggcaatgggt 3061 tcgggcaagt ccagcagcgt gacgtgctgc gtgacgaagg ccggcgactt gccgatctcc 3121 ttggcgatct cgcccttctt cttgcccttc gccagctcgc ggccgatgaa gtcggcgatc 3181 tcacgcgccg tcagctcgtt gcgttgcagg ttctcgataa cctggtcggc ctcgttgtag 3241 tcgttgtcga tgaaggccgg gatcgtggtc ttgtgcgccc acttcgagcc gcgatagcgc 3301 cgcgcgccgt ggttgatgag gtagcgcccc ggtgcgtccg gattctcgcg cacgctgatg 3361 ggcgacttca cgccgcgcgc tttgatggtc tcgccgatct ccgcgatgct ctccggcgag 3421 aagccggggt tgtcggccgt gcgcggctgg tgtgggtctt cgtcgatcag gtcaagcggc 3481 agctcctgcg ggcctgcgcc gccggcgttg gccgccggct gctcgttcag caggccggcc 3541 aggtcgccca gcccgtccag gcccagcccg gacgattgcg gcttgtcctg ctccttcttc 3601 ttggcgttgg tcttggcgct cattgcgcga tctccatctt cgtgaacacg taatccgcca 3661 gcgcacgcac ctcctgggtg gccttccgcg cggcggtctt cttgatcttc cacaccggca 3721 tctgctcgcc cagcgcctcg gcgatgctgt cacgcgcgcc gatgctgaac ggcaagatga 3781 gctgcgggta tgcctgctgc aacgtcgcca ggttgttgac gtggcgcggc ttccgcgcgt 3841 ccaccttgtt cggcaccatg ccgaggaagc gcagcttggg gttctgcttg cgcaggttgc 3901 tgatgaccgc gaccatcttc ttcatgccct gcaagctgta cgcctccatt tcgatgggcg 3961 acagcatgta gtcggccgtc agcacggccg ccgtcatggc gacgccaagg gagggggccg 4021 tgtcgatcag gcacacgtcg aagaactcgc ccagcgcggc cacactggcc cgcagcgcgg 4081 cggccgcctg ggaaagctcc atcttgtcca ggttcgccag gttggcgtct gccgcgatca 4141 gcgccaggct ctcgccctcg cgcttgccga accaataccg caggtcatcg gtgtcgccgg 4201 tgaacaactg gctggcgagg tagcccgatt ggtacgccga cagcgtgaac gatgcgttgc 4261 cctgggtgtc caggtcgatc acggccacgc gaaggccgcg ctccaggaag tcgaatgcca 4321 ggtggcaggt ggcgaacgtc ttgccttgac cgcccttctg aattgccgtg accagtgttt 4381 tcatgacttg ggttcctgtt tcctcttggc gtctgcttcc cacttcttga cgatgaacgc 4441 ttgatgctcc ggcagtaccg ccgtcactcg ctcgaagccc tcggggagct gttcccctgc 4501 tgctgcccat acgcgactga ccgcctgcga caccgccccc ttggtcagcc ccagcgaagt 4561 gacaaactcc gcctggggcc ggccatcgac cagcacgccg cgcgctatgt cgatggtctg 4621 ctgcccgatc tccagcccct tgatggccgt ctggaattgg gcttcggtta gccgtttctt 4681 catggattgc acccataaca ctccacaccc ggtttgttga acaaatggcg gtgccagccg 4741 ccgactatgt gcagaagttt agctaaacca tgcgaagccg tcaagcgttt tagcggctaa 4801 aaatttgttc gcgccttgtc gatggccgat gccgttgcgg ccgtcgcccg cgcctgtcgc 4861 cagtggtcgg aatccaccgc gcacgcgcaa agcgtggccc cgtcctggtc gtagaacacg 4921 gccggccggc cctccacctt cgcctcgatg cgcagcgcct tggcaggcag gcccagcccg 4981 tccgcgatga cggccagggt ggcgcgctgc aaggccaact cttccccctt ggcgtcaatg 5041 agctgtgccg catgggcggc actcaggaag aacgtcatca gcgggcctac ggtgcgcgtg 5101 ccgccgctgg caaagcacac gtcgaaggaa ccgccgccca cgtgcggatc gacgccctcc 5161 acgagacgcc aggggtcaag gccccattct tcggattgcg cgctgtacca gtaggccggc 5221 gcgtcgccgt tcaagtcgct gtccgcgtac tcgcgcacca tgacggccac gcggccagtg 5281 gtcggctcca cgaagccagg cgggtagggg agggtctgct ttgccatgtc aaagcccttt 5341 cggtttgtag atcgaaacga agtaggtgat cgcggtcagt gccgcgaagt acgccaggaa 5401 cgaccagccg gcatacacgc caggcgtgtt ccagtggtag agcatccgca cgaactggaa 5461 gaaggtgatg atcgccagca cccacttgag caccggccag accagcacgg tcgccaccca 5521 tacgaacttg accaggccgg ccaccaggcc ccggccttcg gccttgggtg cggcaggcgc 5581 agcagcgggc gcggcaggct gcaccggctc gggagccggc ggcttgctcg ccctggggaa 5641 cttgacgatg ttggacatgg cttgaccctc cacgcggtta cgtgttgaat gctggatgct 5701 cccactcgga agcatggtta cggtgtgcca gcaccaggcc aagcgccccg gatcactccg 5761 gggcgttcct ccacctgggg ccgtcgaacg tgtggaatgc cgtcattgca gcgtcgctcc 5821 gctcatgcgt cgcacggccg ccgccagcag catttccgtc agctcgttat cttcctccgg 5881 cgtgatgcag ccgccgcaga tgctgccgaa cttctcgcgg gcatcatcgg cgccgatgat 5941 ggtgtggctc aaggttcgga tgctcttgcc gcagcgccgg cagcacgtct cgatgatctc 6001 gatcttgcct ttgctcatgg gactgtttcc tcttggcgtt ccgttgatga cccggccgaa 6061 gccgggccgc cttcccttac cagccgacgc tgcgcttggc ctgctcgacc gcttggctcg 6121 accattcgcc cttggcactg gcctccaggc tcaaggcggc gaaataggct ttgccgcgca 6181 gctcttccgc ctgcttcacc agctcggccg cctcggccat cgtggcctcg atctggtcgc 6241 ggcgggcttg gaagtcggtg gcttccacat tcggcagggc gtcaacccaa ggcatgatct 6301 tgttcttgct catcggaacc tctccggtaa tcgacctggg cggaatgccc ggccttcaag 6361 tgctatatta ggacaaaatg tcctagcctg tcaagcactt tagctaaact attttcgctt 6421 taccgtagtc cgatgcctag cactttagcc gctaaagcct ctttccctgg cgtcaaacct 6481 ctttccagat cagcccgagg ccggcgtagt cgcacagcag cgcccacgcg gcataaggga 6541 tcggcgtgtc ctcgcccacc catcgccgga tcgtccggtc gcccttcggg ccgaggccca 6601 gcaccttcgc ggctttgccg ccggtgaggc ccgccaggcg cagcacctcg cgcacctctt 6661 cgccgctcgg ctgcgcccac cgctcggccg gcttcaagca ctccagccgg atattggcgt 6721 cgttcgtcat tcgtttcttc tcctggtcac gtgataagcc gcagttggtc gaatccgtag 6781 atcgactgaa tgcagctcgg gtctgaatcc accacacggc ggcccgcgcg gttggtcttg 6841 tatgtcaccg gccggtcgtc atgcgcccac acctggcggg tgtctggatg caccttcacg 6901 atgatgacgc gcttgccgat ctccttggcg aacaccggat ggtggacgct cacgatctcg 6961 caccgttggc ctggtgcggg cgtgaactcc accaggtcgg ccgggcctgc atcgccattc 7021 ctggcggtgc tgcaggatgc ttcgcctgcg cccggcatcg tcgcttctgg cgatacaggc 7081 ccagcctcgg ccttgcaatc gtcagctttg gcggtgctgc agcgcatcgc cgtttccgcc 7141 gatgcgggat ctcgctcgcg gcccccggcc tttcccttgg cgttcgacct ggcggccctg 7201 gccgccttga ccttgcccgc cgcctcggcc gcccagcgcc gcgcgatgaa cgccttgtgc 7261 gccggcagca ccacatcgac caagacgaag cccggcggga tcgtcacggt cgccggctcg 7321 cgccgcgccg gcggcaccag gccggccagc caatcgggca ggggagcgtc ggccaagcgg 7381 tcgcggtagt tggcctcgat caacaccggc cgcttcttct cggccagcat ggccgtcagg 7441 atgccgcgcg caacctcgtc cacggtcatg cagccccgcg ccgtgtcgaa gtgtgagcga 7501 tagcccgtcg ccgagataaa cggcctgtcc aggtcaaccg cgtggaactg aaaatgcgcg 7561 ttgagcggcc cgccataacc ggcctcgtac tccaccaggg cgcgcacgtc gcccgccacg 7621 gccaggaact ggccgcgctg gccccacaag ggcacgtccc ccggcaccgc agcgcaatgc 7681 cgctcgatga cgcggccggc ggcctcgtcg tcggccatgc acccgaagtt cgtgccgccg 7741 ttcagcttcc agatgatcgc ctcgtatcgg tcgccggcca gctcggccgc cgccccgtcg 7801 ccgcgcatga cagccgcgtc gatctccacc acggccgcaa cggccgcagc cagcaggccg 7861 tcacggtctg ccggcagctc ggccagcagc tcggccgccg gcgcgctcca gtcctggccc 7921 gtctgggccg gttgctttgt tcgcttcgcc atcgcttgac gtgctcctgg tgcagccccg 7981 gccggagccg gggccgcccc tcatcagtca atagcccggt agatcgcagc ggcctcgggg 8041 tggccggccg cgaagccgcg caggaagtga tagcggtcga tcagggcgtc ggccgcgtcc 8101 gtgccggcga tctcggccgc gagctggccg agcgcgaaca gggttgcgac aatgccggcg 8161 gcgtcggccg acagttcgcc ccggaagccg ttgccgtcta cctcgatctc caggcgctcg 8221 gccaggtcgg gggccaggta gaaaccgccg tccgacaggg tgtagtagtg ccaatacgcg 8281 ccgttgtagc gttcgcagag ccggcgcagc caggcgtaca caagggcctc gccgcgcatc 8341 atcaggcgcg ggccgaagta ggtaggcaag aagtcgaggc gctgggcctc ggcgaccagg 8401 gaagcggtga cgggttggtc ttgggtgttc atcggaactc tccggtagtt gacctgggcg 8461 acatgcccgg ccttcaagac gtatattagg acaaaatgtc ctaacctgtc aagcacttta 8521 gctaaacttt agccgctaaa ctggacttcg cccccttgga gtgataggat tgaatcctat 8581 tgaaccgaat ggaggccgcc atgcgaacca cccagcaact gagcatcacc ctgccgaacg 8641 acatggccga cgtggtgaaa acgaaggtca agaccgggga gtacgcgagc gaaagcgagg 8701 tcatccgcga cggcctgcgt gcgctactcg cgcgtgatcg cgccgtcgag tcctggcttc 8761 acaaccaggt cggcccggcg tatgacgccc tgaaagccga tccctcccga gccgtcaccg 8821 ccgaccaggt gcgcgcccgc ctggccgccg agcatgcgaa ggcgcaatga gctacgcggt 8881 cgtcttctcg cccgaggccg aagagcagct tgccgagctg taccgctaca tcgcggcggc 8941 ggcgtcgcct gacgttgccg ctcgctacac cgaggcaatc gtcacctact gcgaaagcct 9001 gcgcacgttt ccactgcgcg gcaccatgcg cgacgatgtg cggcccggcc tgcgcatcac 9061 gaactaccgc aagcgcgccg tgatcgcctt cgatgtggcc ggcgatctgg tttccatcat 9121 cggcgtgttc tacggcgggc aggactacga gacgatcctg cacgacgacg cggacgactg 9181 aattcccccg cttcttgaca cttgaggggc gcaatcacgc cctgggcctg gcaggccgac 9241 ccctcccttg gcgttcaacc ttgcggcctt cgagctggag ccatcttccg acttggcgac 9301 ggcgcaggag tcaccgcggc cttgacagtt ggggagtcca gagggggcct tggccccctt 9361 tggaagagca cgaacttctg ccaggcgctt gcgcctgcta tggtcagccg tagcgccgta 9421 ggcgctccat tcttggggtg aaggccgtag gccgaggggc aacgcccctg gggggatggg 9481 aggccgcttt agcggccggg tggggatcga gaaggggggg cacccccctt cggcggccga 9541 tcattctgcg gggcaccttg ggccggtttg ccgctttttt cgacacccgg ttataacaac 9601 taggtttaat ataaaggtta tgaagggtta aaagccggtt agcttgaccg gaaaacgcgc 9661 gcaagccgtt gatacgccaa ggaaaaggct cgaagggccg cccctcaagt gtcaatggat 9721 aagcccctca agggtcaata gtctgcccgt caagtgtcaa ggatcgcgcc cctcatctgt 9781 cagcaccccc gcccctcaag tgtcagtacg gcaagggcct tgccaacagg cttatccaca 9841 acttctgtgg ataaagccag cccgatcaag cacataggcc gcctcgacgg cctccggcgc 9901 ggctccagcc ggccgatttc gaggccggcc cctcatctgt cagcatcgcg ccggggtgcg 9961 ctgcccccca agtgtcaaga aacgcccctc aactgtcacc agccggcgtt ttgtccccaa 10021 acgatccaca agggggaacc gcagaattcg gaaaaaatcg tacgctaagc taacggtgtt 10081 ctcgtgacag ctctttgact aggctttcta aggggtcgtc tcagaaaacg gaatctatgg 10141 tcactcccgt ttttgcaaca ccgattttga cgataaattg gcttgcttga atctatccgg 10201 cgtctgaatg ggattttatt cccgcgcctc gatgagttcc gcgcctgatg aacctccaga 10261 aaatatacgg cttcaatgag cctttccgtt ttacaggttc ctcaacaggc cggtgggccg 10321 ttagtatcat caatatcagt attcgcaaaa ccagatcagt gattctttaa accggtgtat 10381 ttctgccgtt atgctacata agtttgctgt cgtgccgtta gggcccaggc tattctggcc 10441 agcttgtttg ccagagcaca agtgacgaca aagttgcttt tcctacacag tagatccctg 10501 acccaatcgg ccaatttgcc agactggtgt tccagttttt gtatgaatac cctggcacat 10561 tgaaccaaca aagttcggat ctttttgtta cctcgcttac taattcccag caatgtcgtc 10621 cgacctcccg tgctgtactg tcgaggcact agccctgttg ccgccgcaaa gtcacgactg 10681 ctggcgtact gcttcccgtc gccaatctca gttgaaatag tactcgctgt cagtgttccg 10741 acgcagggaa tgctcagcaa gcgctgtcca atctcatctt cgtccaactt tcgtttcaac 10801 tgggattcca aatctttaat ctgctcaaca agatagtgat aatgctgttg taatttcagc 10861 aataactggc tgaggtatag aggcaaacta ttgtcctcaa gaagggtact cagtcggcta 10921 ataacggcag ctcctcgtgg aacgctgatg ccaaattcca gcagaaaagc atgcatctga 10981 ttggttgttt ttaccttatc ctgaaccagg gattcacgga cacgatgcag cgcacgcatt 11041 gcctgctgag attcagttct gggctgtaca aaacgcatag acggacgcga tgcagcttca 11101 caaatagctt cggcgtcgac aaagtcgttt ttgttacttt taacgaatgg acggacaaat 11161 tgtggtgata tcagcttagg aaaatgcccc aactcttcca acttgcgtgc cataaagtga 11221 gagccaccac aggcttccat tgcgatggtt gtagcggggc atgtcgccaa aaattcgatt 11281 aactttggcc gtgtaaattt tttacggtaa acagccttgc cgcgacgatc ttggcaatga 11341 atatggaaag agtttttacc cagatcgata ccaatgagcg caatgttttc catgatagtt 11401 ctccgaatga aagcctatcc tcagcatagt accgggaagg aaggagtgac catctcatta 11461 aataaagcac gctaaggcat agccgaacct gccaagcttg ctccacctgt agtgacgcga 11521 tcagcgggca ggaaacgttc ccccttcgcg catggcaggc gcacaccaac tcagacagca 11581 cggcctccat gcgcgccagg tcagccattt tctcgcgcac gtccttgagc ttgtgctcgg 11641 ccagactgcg cgcttcgcgg gagaaggatg ttgatcggtt gatcggttga tcggttgatc 11701 gattttcgac gagccttgga gtggcccagc tttgttaagg ctttcggatg gattttccct 11761 tgcctctttc agcaacgata aattccagcc atcgaacacc ttgagtccgg ctcgggttcc 11821 aatgggaatg tgtggtgcca gccggaacga gcaggctgtc accgggtttc agggtaacgg 11881 gttccttgcc ctcttcctgg aacaccggtg tcccggaaag tacatagaag gttaccgccg 11941 ccggatggta atggcgacgg ttgataccgc ccggctcgta cttcacgtcg atgacgatga 12001 actcgaggtt ctccgcgccg tccactccgc gcaccacgag gtcgttgggt gtgaccccgg 12061 tcttttgcgg gacgtctttc ggatcctgcg cgtaggctgc ggacacagcg agagctgcgc 12121 cggacagggc agcgaggagc ttggtgcgtc ggttcattac ggagtccatt cacatcactg 12181 atggacggta gcctacactg cgagctatgc ttgcggtatc gattctcgtc gatcttatat 12241 acctttcaga gcatagccaa tgagccccac agacgctgtc gccaggcacg tgaccctgcg 12301 ggagctgcgg ctgcttctcg cggtcgcccg atcgggcagc atcctcaagg ccgcgaacga 12361 gatcggactc acgcagcccg cgttgtcgcg atccatcgca gatctggagg gcgcgttcgg 12421 ggtgcggcta ttcgatcgca ccaatcgcgg cgttgccccg actccgcacg gcgaggttct 12481 gctgcgtcgt gcaacgggag tctttgagga gcttcgtcag gccgtcaatg aactgcgtgc 12541 cttggccgac gcagcccatg gcgagctgcg catcggcggc acaccggcca tgtgtgcggg 12601 gctgctgcct cgcatcatcg gcaccgtccg gagcgaccgc cccagattgc agtttcatgt 12661 cgcagagctc gagtcaggtc cgttggcgag tgaagttgtc ggcaggtcgc tcgatctggg 12721 tctcggtcgc gagcatgctg tcagggagag ccacgacctg gtcttcgagg gactgttcga 12781 agatcggctg ttcgtcgtcg cgggatcgca gcatcccttg gctgagcgac gatcgatttc 12841 cctggaggaa accctgcgtc atcactgggt gctgcccacg gaaggggcgg tcacagcgca 12901 tcttcagggc gaatttggtc gacaaggact ggccatcccg gaggcagcga tcaccacgat 12961 gtccatgctt gtccgatgcg agctgatcgc gacgggatct ttcctcaccg tcatgtacgg 13021 ttcagttctc cgattcggga acgcgccgaa gtctttgcgt gtcctgccgg ttgatctgcc 13081 gtccggcata ccagtgggag ttattcgctt gaagaatcga acccttgcgc caagcgccga 13141 gatgttcatc caggcgagcc gccggatggt ccggtccatg ccttcactga gcgcaagtca 13201 gctgcggcgg gctcggccgt gatagggcct catgtcggca ggttcttcct cgacgcggtt 13261 gacatcggca gcggcaatgt gagccctggc gacgacggct aaatagctgg tcgagcaagg 13321 aggtcacgtg agattagaag agctggcact tgatgccgta gagaggcgtg tcaaggcaat 13381 gaagccaacg ctaaagcttt atttaatgag atggtcactc ctccttcccg gtactatgct 13441 gaggacaggc tttcattcgg agaactatca tggaaaacat tgcgctcatt ggtatcgatc 13501 tgggtaaaaa ctctttccat attcattgcc aggatcgtcg cgggaaggct gtttaccgta 13561 aaaaatttac ccggccaaag ttgatcgaat ttttggcgac atgcccctcg acaaccatcg 13621 caatggaagc ctgtggcggt tctcacttta tggcacgcaa gttggaagag ttggggcatt 13681 ccccaaagct gatatcacca caatttgtcc gcccgttcgt taaaagcaat aaaaacgact 13741 ttgtcgacgc cgaagctatt tgtgaagctg catcgcgtcc gtctatgcgt tttgtgcagc 13801 ccagaacgga atctcagcag gcaatgcggg ctctgcatcg tgtccgtgaa tccctggttc 13861 aggataaggt aaaaacaacc aatcaaatgc atgcttttct gctggaattg ggcattagcg 13921 ttccccgagg agctgccgtt attagccgac tgagtaccat tcttgaggat aatagtttgc 13981 ctctttacct cagccagtta ttgctgaaat tacaacagca ttatcactat cttgttgagc 14041 agattaaaga tttggaatcc cagttgaaac gaaagttgga cgaagatgag gttggacagc 14101 gcttgctgag cattccctgc gtcggaacac tgacagcgag tactatttca actgagattg 14161 gcgacgggaa gcagtacgcc agcagccgtg actttgcggc ggcaacaggg cttgtacctc 14221 ggcagtacag cacgggaggt aggacgacat tgctgggaat tagtaagcga ggtaataaaa 14281 agatccgaac tttgttggtt caatgtgcca gggtattcat acaaaaactg gaacaccagt 14341 ctggcaaatt ggccgattgg gtcagggatt tactgtgccg gaaaagcaac tttgtcgtca 14401 cttgtgctct ggcaaacaag ctggccagaa tagcctgggc cctaacggca cgacagcaaa 14461 cttatgtagc ataacggcag aaatacaccg gtttaaagaa ttactgatct ggttttgcga 14521 atactgatat tgatgatact aacggcccac cggcctgttg aggaacctgt aaaacggaaa 14581 ggctcattga agccgtatat tttctggagg ttcatcaggc gcggaactca tcaaggcgcg 14641 ggaataaaat cccattcaga cgccggatag attcaagcaa gccaacttgt cgtcaaaatc 14701 ggtgttgcaa aaacgggagt gaccatagat tccgttttct gaggcgaccc cctctatgcc 14761 ccgagaaagg gccagaaagg cccgccaggg cctcgtagcc tagcggcgag gccaccggcc 14821 cggtgagcgt cgggaaggcg ctggaagccc gccaggggcg agaccggccg tggccgcctg 14881 gctcgatgcg tagcacgaca tagccggttc tcgcggccgc cggccgggag aatcccccgc 14941 agcttggccc ctcaaatgtc aaagagtgga tctcatcgtc ggaagtggcg atgcgagatc 15001 cagcggcggc cgtcatcgtc ggaactggcg atggggccct cggggcatcg ttggatgtgg 15061 cgatggtcga ccgtggccag gacgtggcca gcctcgccgg aagtgacgat gctgcagctc 15121 gacgtgcgcg agctggtgcg cggtactgcc tcgccggaag tggcgatgct cgagaaaaaa 15181 agccgcctcg atctcgggcg gctccagggg agggcagggg ggcgatcacc gcttgcaatg 15241 caccaggtcg tcgttcaccc aggcactttc gaccaggccg ttttcgcgca gctcgtcgca 15301 cgcttcgcct acctgctcgc gccacttctt cggccgggtg gaatccgagc cgcacatcag 15361 ccggaacgtc tccagcttga gcgggtacgg ctccttgtgg gtggcgaagt agtcgaacat 15421 gcggccgtcg cggttgggcg acagcttgcg gtacttctcc cacacgaatt tcgtgtagtg 15481 gtcgccggcg aacagcacca cgatttcggc gtcgatctcg acctggcagc gcgacgtgcg 15541 cttgccgcga tccaggacgc ggaagcgccg gatcagcgac accgattcga gccggccgat 15601 gcgttgggat gagaactgca tggccgacgc ctggagccgc gtcaggcatt cctcggccct 15661 tgtgtagtac cgaccgttga ttgaccagtc caagtcctgg caaagctcgt agaacgtgaa 15721 ggaaaccggc tctccgagcg cggtgccgtt cgcgtactcc agcacctggg cgaataccag 15781 ctcgtcgtcg tcggcgcgca gctcgatccc ggtgtaggtg atctccacgt ctttgttgac 15841 gtggtagatc gactggcctt gcagcgcggg gcgcggcacc ttcttgttgc ggacggtgaa 15901 gatcgccgac cgcccgaagt cgttgggcag tgccgcatgt gatccggtcc agggagccag 15961 gtcgaacagc gagagctgca tgtccttgat ctgctgcttc gtgtgcttga gcaaggccgt 16021 ctgcttggcc tcgctgacct tctcggccag ctcaccgccg gccgttcgct tcttggtcgc 16081 catcgcacta ctccgtttgt cctgggccag cgcgccgatc tgctcggcca tcttgttcac 16141 ggcggtgcgc ggttcgggcg gcaggcccat cgtgcgcgca agctcggccg attcctgcgc 16201 catgcgctcg gatcgctcga cggcggcact tgccggcgtc ggtagcttcg gcggcaaagc 16261 cgcctcgttg tcgccggccg tggccggcag ctcgaagagg gaaccggcgg ggcggaaggc 16321 cccgccggcg ctgcccgagt ccctgcgagc ggcggcggta cgggcggcaa ggtcggtggc 16381 gtcggcttcg ctaagcccgc cctcgatgag cttgcgcctg tattcctgct cgttgaactc 16441 gttctgcatc taatctccct cctagcatac tgcccggccg tggccgggcc tggccttact 16501 ggccgccgcc tggcgctttg gtgtccaggt attcgatttc ctcggcgatg aaatcgaacc 16561 cgtattcggt cttgccgtcc ttctcgtact tcgtcggctc gatgcggccc tggacgaaca 16621 ccttggagcc tttgcccagg tacttgcccg cgttctcggc caggccgccg aacgacttga 16681 tgcggaagaa gtccgtctgc tcctgcttcg caccggctgc gttgcgccac acgcgattga 16741 cagccaggtc gaaaacggcg cgggcgctgt tttcgctatg gcgaacgtcg gtatcgcggg 16801 taagattacc gataaactgg aacaggttgt ggctcattcg tcatgctcct ttcgctaatg 16861 gagtcgtcag tttagctaaa cctgcgtccg tggtcaagaa ctttagcggc taaaattttc 16921 tgccgcccgc accgagaagg catacgggcc atgtacaact acatcttctt cacgaacgtg 16981 ctccggctgc tcgatgagcg gcacatgacg aaaaaggagc tatcggacag gtcgggggtt 17041 tcgatctcct tcctgtccga tctcactact ggcaaagcca acccctccct aaaggtgatg 17101 gaggacattg cgcaggccct tgaaactccc ctgccgctcc tgcttgaatc gaccgacctg 17161 gacaaagaag cccttgacgc cctggccggc ggcaaggcac cccgaagcct gccgccaggc 17221 ttcgagcgcg tggcggccgt gctgccagaa caccaggcgt tcatcgtcaa gaagtggggc 17281 gaagcgacaa ggaagaaact tagagggagt tgacgccagg atgtgagaag ggaagggaag 17341 cggcgcggaa ctgagccaca agagccagcc aagttttagc cgctaaagcc cgccggggtg 17401 gctcaacccc cggacaaccc ataacgcaaa cgccacgggt tcggcgcgag ggcacggagc 17461 atgccgcgtt gtcgcctctt tcgcccctgc aatccgcgat gcaacgtcgc gccgaagtca 17521 cccttgtgcg cttcggtgtt gcggtcgaac ttagttcgat atatcgtatg aacctgtgta 17581 gaatgcgcga gacgcaacgg catacagggc atacggaatg accgaccaga aaccagaaca 17641 caacagcatc aaggaacggg cgaagaagaa gctcgaacgc gacatggggc cggagctgct 17701 ggccgccctc aacgatccca agaccgttga aatcatgctc aacgcggacg gcaagctctg 17761 gctcgaacgc ctgggcgagc cgatgaagtg catcggcacg ctgcgcgtcg cgcaggcgca 17821 agccatcatc gaaaccatcg cgggctacca cggcaaggaa gtcacgcgct ccaagccgat 17881 cctggaaggc gagctgcccc ttgatggcag tcgcttcgcc ggccagctcc cgccggttgt 17941 gcccgcaccc accttcgcca ttcggaagaa gggcgtcgcc atcttcacgc tcgatcagta 18001 cgtcgaacgc ggaatcatga ccgcgccgca gcgcgaggca ttgattgcag cggtgcgcgc 18061 gcaccggaac atccttgtga tcggcggcac cggctcgggc aagaccacgc tggtgaacgc 18121 gatcatcaac gagatggtga ttcaagaccc gaccgagcgg gttttcatca tcgaggacac 18181 cggcgaaatc cagtgcgccg ccgagaacta cgtccagtac cacaccagca tcgacgtgaa 18241 catgacggcg ctgctgaaaa ccaccctccg catgcgcccc gaccgaatcc tggtcggtga 18301 ggtgcgcggt cccgaagccc ttgatctgtt gatggcctgg aacaccgggc acgaaggagg 18361 tgctgcaacc ctgcacgcaa acaacgccaa agctggattg gatcggctcg ccatgctcat 18421 cagcatgcac cccgattccc cgaaacccat tgaaccgctt atcggcgagg cggttcacgt 18481 ggttgttcat atcgcccgcg tcgaaggctc gcggcgcatc caggaaatct tggaggtttc 18541 cgggttcgcc aacggccagt acatcaccaa aaccctctga ctaggagtta cgaccaatgc 18601 aagcaacctt cccggcattc cgcctcaacc gcaacgccct gttctacatg ggcctcttcg 18661 ccctcctggc gttcttcctg ctggcccccc agcacgcatt cgcctccgag ggcaccggcg 18721 gctctctgcc gtatgagagc tggctgacca acctccgcaa ctccgtcacc ggcccggtgg 18781 ccttcgcgct gtcgatcatc ggcatcgtgg tcgccggcgg catcctcatc ttcggcggcg 18841 aactcaacgg cttcttgcgc acgttgatct tcatcgtcct ggtcatgggc ctgctggtcg 18901 gcgcgcagaa catgatgagc acgttcttcg gccgtggcgc ggaaatcgcc gccctgaccg 18961 atggcgcgct gcaccaggtc aaggtcgccg cgctggacgt ggccggcttc cccggcgaag 19021 ccgtcatgcg ctgggccgag cgcggccaca tcgcggggta agtcatggct ctgcgcgcga 19081 tccccatccg tagggccggc aaccgagaaa acctgttcat gggcggggat cgtgagctgg 19141 tgatgttctc gggcctgtgt ggcggcgcgc tgattttcag cgcccaagaa gtgagggcaa 19201 cggtgttcgg catcgccttg tggttcggcg cgctcttcgc gctgcgcctc atggcgaagg 19261 ccgatccgaa gctgcgacac gtgtacctgc ggcaccgccg gtacaagccg tactacccgg 19321 ctcgcagcac gcccttccgt gacaacacgc cgagtcaagg gaagcaatac aaatgatcga 19381 agcaatcgca attgccattg ctgtgctcgg tgcggttctg ttgctcatcc tctttgcccg 19441 catccgggct gtcgatgccg agctgaagct caagaagcat cgcgccaagg atgccggcct 19501 ggccgatctg ctcaattacg ccgccgcggt cgatgacggc gtgatcgtgg gcaagaacgg 19561 ctcctttatg gccgcctggc tgtacaaggg ggatgacaac gccagcagca ccgaggaaca 19621 gcgggaaatg gtgtcgttcc gcatcaacca ggccctggcg ggcctgggga acggctggat 19681 ggtgcatgtc gatgctgtgc gtcggcctgc gccgaactac tcggagcggg gcgtgtcatc 19741 gttccccgac tccgtttcct tcgccattga cgaggaacgc cggcgcttgt tcgagggcct 19801 gggcgcgatg ttcgagggct actttgtcct gaccgtcacg tggttcccgc cagtgctggc 19861 ccagcgcaag tttgtcgaac tcatgttcga tgacgatgcg gtggctcccg accatacggc 19921 gcgcactacg ggcctgattg cgcagttcaa gcgcgagatc accagcctgg aatcgcgcct 19981 gtcctcggcg gtcaagatga cgcgcctggg cggccaaaaa gtcgtgtcgg aagagggcag 20041 ggaagtcacg cacgatgact tcctgagctg gttgcagttc tgcgtgacgg gcctccatca 20101 cccggtcatg ctgcccagca atccgatgta cctcgatgcg gtaatcggcg ggcaagagct 20161 gtggggcggc gtcgtgccca agatcgggcg caagttcatc caggtggtcg ccatcgaagg 20221 cttccccttg gagtcaacgc ctggggtgct ctcggccctg gccgagctgc ccagcgaata 20281 ccgctggtcg agccgcttca tcttcatgga tcagcacgag tccttgaagc acctggacaa 20341 gttccgcaag aagtggaagc agaagattcg cggcttcttc gatcaggtgt tcaacacgaa 20401 taccgggtcg atcaaccagg acgcggccgc gatggtcggc gacgccgagg cggccatcgc 20461 cgaggtcaac agcggcttgg tggcggccgg ctactacacc agcgtggtcg tgctgatgga 20521 cgaggatcgg gagcgcctgg cggcctccgc gctcctggtc gagaaggccg tcaaccgcct 20581 ggccttcgcg gcccgtatcg agacgatcaa cacgctcgat gcgtacctgg gcagcttgcc 20641 cggccacggc gtcgagaacg tgcgccggcc gctcatcaac acgatgaacc tggccgacct 20701 gctgccgaca agctcgatct ggacgggcag cgccacggct ccgtgcccga tgtacccgcc 20761 gctgtcgccg gcgctcatgc actgcgtgac ggtgggcgct acgccgttcc gcctgaacct 20821 gcacgtgcgc gacctgggcc acaccttcat gttcggcccg accggcgcag gcaaatcgac 20881 gcacctgggc atcatcgccg cgcagctccg tcgctacgcc ggcatgtcga tctacgcctt 20941 cgacaagggc atgtcgatgt acccactcgc ggccggcatc cgcgcggcca cgaagggcaa 21001 gagcggcctg catttcacgg tggccgccga cgatgaccgc ctggcgttct gcccgctcca 21061 gttcctcgaa acgaaggggg atagggcctg ggcgatggag tggatcgaca ccatcctggc 21121 gttgaacggc gtcaacacca cgccggcgca gcgcaacgag atcggcaacg cgatcatgag 21181 catgcacgcc agcggcgcgc gcacgctctc cgagttctcg gtgacgattc aggacgaggc 21241 gatccgcgag ggcatcaagc agtacacggt ggacggctcg atgggccacc tgctcgacgc 21301 cgaagaggac ggcctgtcgc tgtccgactt cacggtgttc gagatcgaag agctgatgaa 21361 cctgggcgag aagttcgcgc tgccggtgct gctctacctg ttccgccgca tcgagcgcgc 21421 actgaaaggc cagccctccg tcatcatcct ggacgaagcc tggttgatgc tgggccaccc 21481 cgcgttccgc gccaagatca gggaatggct caaggtgctg cgcaaggcca actgccttgt 21541 gctgatggcg acgcaaagcc tctccgacgc ggccaactcg ggcatcttgg acgtgatcgt 21601 ggaatcgacc gcgaccaaga ttttcctgcc caacgtctac gccagggatg aggacacatc 21661 ggcgctctat cgccgtatgg gcctcaacgc gcgtcagatc gaaatcctgg cgactgccat 21721 tccgaagcgt cagtactact acgtctcgga gaacggccgc cgtctctatg accttgccct 21781 ggggccgatg gccctggcct tcgtcggtgc gtccgacaag gaatcggtcg ccaccatcaa 21841 gagcctcgaa gccaagttcg gccacgaatg ggtgcatgag tggctggccg cccgtgggct 21901 gaatctcaac gactacctgg agaccgcatg agcatcgccg acaccctcaa gggcttgatc 21961 ttcaagaagc ccgccaactc cgccgagccg cgcgatccgc gccgctcgaa ggaaccgctc 22021 gccggcggcc gccgtgcggg cgaggccgag aacccctacc tggccgcgcg ccgcacctgg 22081 aacgatcacg tgggcggcgt cgtctcgcag cgccaaacct ggcaggtgat cggcatcctg 22141 tcgctgttga tcgcgctggc cggcgtgggt ggcgtgatcc acatcggcag ccagtcgaag 22201 ttcatcccct acgtggtcga ggtggacaag ctgggccaga cggtggccgc cggcccggtg 22261 caggccgcag ggaaggccga tccgcgtgtc atccacgccg ccgttgcgga ctggatgagc 22321 tgcgcgcgca tggtgtcgcc tgacgtggcc ttgcagcgca agtgcgtgtt caaggcgtac 22381 tcgatgttcg cccccaacga tccggcgacg ccaaagatga acgagtggtt gaacggcacg 22441 cccgattcca gcccgttcaa gcgcgccgag aaggaaatgg tcagcgtcga gatcaagacc 22501 gtcatcccgc aaacgcccga cacctggcaa gtcgagtggg tggaaaccac gcgcgaccgc 22561 caaggcacgc tgaaaggtca gcccgtcacc tggcgcgcgc tcgtgactac ctacatcgcc 22621 gaggtcacgc ccaacaccac cgatgagcaa ctgcggaaca acccgttgag catctacgtg 22681 cgtgattact cctggtcccg catccaatga attcgaggtc atccaccatg aagaaaaccc 22741 tctccgcttt gatcgtgggc gctgctgtgg cggtgccctc cctggctctg gccgcccctg 22801 gggacgacat tgccgacaag tatttcaaca agaccaaccc gacgctgacc gctcaagagc 22861 gcgcggcgct cgccatcgcc aaacggtggg aagcggggtc ggcgacgggc atcaagccgg 22921 tggccggctc gggcggtgcc atcaagttcg tgtacggtgc gcagcagccg agcatcgttt 22981 gcgcggtgct ccaggtgtgc gacgtggcct tgcagcccgg cgaacaagtg aactcgatca 23041 acctgggcga cacggccagg tggacggtgg aaccggccat caccggcagc ggcgcgaccg 23101 aggttcagca cctcatcatc aagccgatgg acgtgggcct cgaaaccagc ctagttgtga 23161 tcacgaaccg ccgcagctac cacttccgcc tgcgctcgca tcgcaccgag tacatgccgc 23221 aagtctcgtt cacgtacccc gaggaagcgc aagccaagtg ggacgcgatc cagcgccgcg 23281 agaagcagga acgcaccgac aacaccctgc cggtgacggg cgagtacctg ggcgatctct 23341 cgttcgacta tgagctgtcc gggtcggcga gctggaagcc tgtgcgcgtc tacaacgatg 23401 gccgcaagac catcatcgaa atgcccggca cgatgcagca gaccgaagcg ccgacgctcc 23461 tggtcgtgcg caaagagggc ggcttgttca ccgacgacga aacggtgctg gtcaattacc 23521 gcgtgcaggg caatcgctac atcgtggaca cggtgtttga ccgcgcgatc ctgattgccg 23581 gtgttggcag tagccaagac cgcgtgacca tcagccggag gaagtgacca tgcgcaagat 23641 cgtctctctc gcgctgctcg ccctcgccct gggcctcggc ggctgcgcaa ccaccagcca 23701 gtacggcaac ttcgtccagt cggccgcgct cgatcagcag aagctcgcca ccgacgcggt 23761 gcagcagctc gccacgctgt acgcgccggc gcgcacgcgc ctggagctgc aacagccgac 23821 gcccgatccg ttcggccagg cgctcgtcaa ttcgctgcgc gacaagggct atgccctcct 23881 ggagtacgcc ccggccggcg cttccacgca ggccccggcc tcggcggcat cgcaggcgag 23941 cgcaccggcc accacggccg cgtcgggcgg cctgccgttg cgctacgtgc tcgaccaggc 24001 tggcgactcg aacctgtacc gcctgacctt gatggtcggc aatcaatcca tcacccgccc 24061 ttacctggcg caaaacggca cgttcgcgcc ggccgggtac tgggtgcgca aggagtgacg 24121 ccatgacaga aaacgccgat cagatggcac ctgacgcttc gcctggcgaa gtgtccaaga 24181 aggcgggcgt ccgtcgcgtc aacaacatgc ccatgtacat cctcggcggc gtcctgctgt 24241 cgttcgtgct ggtcatggcc ctggtcgcgg cggatcgcgc ggccaagcag aacgcgccgg 24301 cggacggccc caaggagaag gccggcaaca cgtcgatgtt cgccaaggag atcgcaggcg 24361 acaagaccgg cggcttgatc gagccggcaa gcccgctcaa ggtgcccgac atgccgaccg 24421 gcccggcgtc ggctccgctg gagatcgcgc ggccgtccaa cccggaagcg ccgccggccc 24481 cgccggccaa ccccggcaac ccgggccagc cggtgaacga cgacgaggcc cagcgcatcc 24541 gcatggcgaa gatgcagatg ttcggcgaag ccgtgaaggc caagaccacc gtgcgcgtgg 24601 atggcccgcg tagcaacggc tccgcgccgg gtggcccgag cacctacacc ggcacgccgc 24661 agacgcgcga tgaaatgctg aaccgcatcg cagcggtgca gcagcaaatt gacgcgcagc 24721 gcagcaacga tccgaccgcc gcctatcaag cacgcctggc gcagattcgc ggcatgggcg 24781 tcggtggtgg cggcgcggct ccggccgccg gcggtatggg cgcgggcggt gcgccgcagc 24841 tcctgcaaac ctcgaccagc ggtggcgggc gcaacagcat ggcgcagttc ggccaaggtg 24901 ggcagggcga ccgctggaag ctggattcgc agccggaagc gccgcgcaca ccgttcgagc 24961 tgcgcgcggg cttcgtcgtg ccggccacgc tcatttcggg catcaactcc gatctgccgg 25021 gccaaatcat ggcccaggtc gcgcaggacg tgtacgacac accgaccggc aagcacctgt 25081 tgatcccgca gggatcgcgc ctcgtcggct cgtattcgag cgacgtggcc tacggccaag 25141 cgcgcgtgct ggttgcgtgg caacgcatcg tgttccccga tggcaaggcg atggacattg 25201 gcgcgatgcc aggcgcggac agcgcgggat acgcgggctt ccacgaccag gtgaacaacc 25261 actatgtgcg cctgttcggc tcggccttcc tcatgtccgg cgtgacagca ggcatcacct 25321 acagccaacg ccagaaccag gccacaaaca cctatggcgc accgagcgcc agcagtgccc 25381 taagcgaagc cctcggccag cagctcggcc aggttacggc gcaactcatc gccaagaacc 25441 tgagcatttc gccgacgctg gaaattcggc cggggtatcg cttcaacgtc gtggtcacga 25501 aggacatgac gttttccaag ccgtaccgtt ccttcgatta ctaacgccat aggagaaaag 25561 caccatgaag ccgaagtttt tagccgctaa attggccctc gtcattgctg tttcgagcac 25621 gctggcggtc acacctgtgc aggctggcat ccccgtcatc gacggcacca acctgtcgca 25681 gaacatcatg acggccatcg aatcggtggc ccaaacgctc aagcaaattg agcagtacag 25741 cacccagctc cagcagtatc agaaccagct ccagaacacg atggccccgg ccgcgtatat 25801 ctgggatcag gcgcaatcga ccatcaacgg gttgatgaac gcggtcaaca cgctggatta 25861 ctacaagacc caactcggca gcctggacag ctacatcggc aagttccagg acgtgaacta 25921 ctacaagaac tcgccgtgct ttacggcggc agggtgctcc gacgcggaac gcgcagcact 25981 tcggaatgtg gcccagctcg cgagcgagtc gcagaagaag gccaacgatg ccttgttcaa 26041 gggcctcgat aggcagcaaa cgaatctcac ggccgatgca gcgacgttgc agcgtcttca 26101 atcggcagcg cagggcgcgc agggccaaat gcaggccatc ggttacgcca accagctcgc 26161 cagccagcag gccaaccagc tcttgcagat tcgtggcctg ctgatcgcgc agcagaacgc 26221 gatggcaacc aagatgcagg ccgacgccga caaggaagcc cagcaggcgg cagcggccgc 26281 acaactgcgc cagggcagct accgggccag cccggcgcgc acctggtaag gggggattca 26341 tgaaagcaat caaggctctg tccttggcct cggccgccct cgtggcggcc ttggtcgccg 26401 gctgcgacaa caagccggcc acggccccca tgccggaagt gaacgacgag agctgcaagc 26461 ccgagaacat cgccaagatc gaggacaagg gcgtccagca ggctttttcg tcgctgtgct 26521 tgcgtcgtgg tggggatttc aagcccagcc cgaaacgcga atggtgaggt gctgacgatg 26581 agaatgccag ccaatctaaa aaccctcgcc ctgccgctgt tcgtctggct ggcgttcttc 26641 gcggtcgatg cccacgcggc catcgacaac gccggcgtgt tcgatagcgt gctggatcgc 26701 taccagaccg ccgcgagcgg ctgggccggt gtcatcacca cggccgcaac ctggctcttc 26761 tggacgctgg ttgtgatctc gatggtctgg acgttcggca tgatggcctt gcgcaaggcc 26821 gacattggcg agttcttcgc ggagttcgtc cgcttcacga tctttaccgg cttcttctgg 26881 tgggcgctga ccaacggccc taacttcgcc tcgtccatct atgcgtcgtt gcggcagctc 26941 gccggcaacg cgacgggcct gggcaatgct ctgtcgccct cggggatcgt ggacgtgggc 27001 tttgcgatct tcgacaaggt gatggatcag tcctcggtgt ggtcgccggt ggacagcatg 27061 gccggcatcc tcatggccgt ggcgatcctg gtcatcctgg ccctggtcgg tgtgaatatg 27121 cttctgctgc tcgcgtcggg ctgggtgctc gcctacggcg gcgtgttctt cctcggcttc 27181 ggtggttcgc gctggacttc cgacatggcg atcaactact acaaggtcgt cctgggcgtg 27241 gccgcgcagc tcttcgcaat ggtgctcctg gtgggcatcg gcaagacctt cctcgatgac 27301 tactactcgc gcatgagcgc cggcatcagc ctcaaggaaa tgggcgtgat gctgatcgtc 27361 gtcatcatcc tcttggcgtt ggtcaacaag attccgccgc tcatcgccgg gatcatcacc 27421 ggcgcgagcg tgggcggtgc cggcatcggc cagttcggtg caggcgctgc gttgggtgcc 27481 gcaggcatgg cagcagcagc ggccgcgacc ggcggcgccg ctctggccgc cggcgcagcc 27541 tcggccgccg gtggtgcctc tgccgtcatg gccgccttct cgaaggccaa tgagaacgtg 27601 tcggcaggca cggacgttat gtcggccttc tcgggcggcg gcagctcggg cggcggtgcg 27661 ggcggcggcg gcgacgccgg caccggcagc acgcccttcg ctcaggctgc gggctttagc 27721 ggcagctccg gcggtggctc ttcgtcgggt ggcggcagcc cctcgaccgg cagcagctcg 27781 ggcagctcga agggcggcga taagggcggc ggcaaagccg acgccggcgg ccagggcagc 27841 agctcgacgg ccagcaccgg cagcagtgcc gacaaggccg ccaagaacga acccaagccc 27901 gccggcgggg cagggcaagg gcagcaggcc gcaccgggca gcaccggccc cggcttgctc 27961 gcatcggccg catcggccct cggcacggcc ggccgcatcg ccgccgacgc cggcgcgaac 28021 ttggcgaagg gaaccgccga tgttgccaag gccaaagccg cgagcctgcg cgaagccgca 28081 gccgagcgga tcgccgacac cactggcgga aagatcgccg ccgcgatcaa ggcgcaagga 28141 agcggcacgg ccgagaacat cgacgtgccc gaccagcagc ccgcgccgag cttcggcgac 28201 aacaggctgg caggcggccc cgccgatgcc gatcccgagt ccgaagtagc tgcgttcgcc 28261 aaccgcgagc aaggccgcga cggcacaact gcgtaaccaa ggagagtcca accatgaaga 28321 agaaactgtt tgccctggcc gccctcgtgg cagccctcgg atcgaccgcc ggcacggcca 28381 gcgcgcaaga cgtgctgacc ggcgacacgc gcctggcctg cgaggcgatc ctgtgcctgt 28441 cgtcgggcac gcgcccgagc gaatgcacgc cgtcgctgtc gcggtacttc aacatcacga 28501 agcgcaagct gtcggacacg atccgcgccc gcctgaactt cctccagctt tgcccggtgg 28561 cgagccagac gccggaaatg cagtcgctcg tgtcggcgat ctcgcgcggc gctggccgtt 28621 gcgacgcgca gtcgctgaac tcgacgttgg tgatgtggac gggcggctac gacgatgggc 28681 gcacgtacat cagcaaccag ttgcctgact actgcggggc ctacaccggc cacgcctaca 28741 ccgacttcgc cagcagcggc acgctgccgc gctatgtcgg gacgccagag cggggcgggt 28801 attgggtcga agcgcgcgac tatgaccgcg ccttggccga gtacaacgaa cgcatccggc 28861 gcgaggacga agagcgccgc cgtcagtcct ggctgaactg agggagggga gggcatgccg 28921 ttcttcgccg atctgccgcc gcagctccag gagcgcgtcg tctgctcgat ctcggccgcc 28981 gtcaagtacg aggtgccggt caacatcgtg ttggccgtcg ccgagaaaga gggcggcaag 29041 ccgggccagt gggtgcgcaa ctcgaatggc acgcatgacg ttggcccgat gcagttcaac 29101 accgcgtacc tgggcgacct ggcccgatac ggcatcacgg cgaacgatgt ggcggctgcc 29161 ggctgctact cgttcgacct ggccgcctgg cggctgcgga tgcacatccg caacgacaag 29221 ggcgacctct ggacgaaggc ggcgaactac cactcgcgca cgccgcagta caacgcggtg 29281 taccgggccg acttgatgcg caaggcgtcg aagtgggccg attggctcga agctcggttc 29341 gtcacgcttg acgtgacgaa ggccggggcc acgcccttga cgcccagcca gcccgcgacg 29401 gtggcccagc gggcgacgcc ggcggccagg ccggcaccag caccccagca ggccgcccca 29461 gcggccgcag cagctcgcag cgtgtcggtg gccggctacg tgccccgcac ggtgtctttc 29521 aacacttcac gcgaggggtc ggccgagtag cccctcttcc gaattagcgg ctaaacatgg 29581 acaaattcca cgccttcatg atgcggtata cgctgggcgt cggccggttg cttcaagcct 29641 attgcaagtg ggcggaagga caggccaaga accagctcga tttgcttctg ctgggcctcg 29701 gcccgatctt cgccttgggc cttctgctgt gggcgctgcc ggcgtggatc ggcaagccca 29761 tcgccttcgt gctctcactg ccagcgctct acatcatctt cctggtgctg cgcgcctacg 29821 cgattcgcgg gggccggcgc tgatgaaggc cctgcggatt cctgatggaa ccgtcgaagc 29881 gttgaagtgg ctcgcactgg ttctcatgac cggcgatcac gtcaacaagt acctgttcaa 29941 cgcgacgctg ccggtgctgt tcgaggccgg ccgcgtggcg ctcccccttt tcgtgttcgt 30001 cctggcctac aacctggccc ggcgcggcac gctcgaacgc ggcgtgtacg gccgcaccat 30061 gtcgcgcctg gcgatgttcg gcgcgctggc ctccgtgccc ttcgtggccc tcggcggcct 30121 gtacgccggt tggtggccgc tcaacgtgat gttcacgctg ctggtcgtca cggccacggc 30181 ttacctggtc gaacgtggcg gcaagctgca cctggcggcc gccggcgtgg tgttcctggt 30241 cggcggcagc tcggtcgaat attggtggcc ggccgtggct ttcggcctgg cggtgtggtc 30301 gtacacgcgc cggccgagct gggccgccgc ggcggtcgcg gtgctggcct gcgcggccct 30361 gtggttcgtc aatcgcaacc tgtgggcctt ggcagccctg ccggtgctct tcctggcctc 30421 gcgggtggat gtgcgcgtgc cgcgcctgcg ctgggccttc tacgcctatt acccgctgca 30481 cctggcctcg ctctggttga tccgcatccc catgagcaag gccggctacc tgttcttctg 30541 attggagtcc tgccccatgc gaaaacccgt tcttctggcc ctctctctgg cgttcctggt 30601 cagcgcgcaa agcgcactgg ccggcgacgc cggcaacttc ggcacgccga tcaagtccgg 30661 cgtatcggtg tccttccccg acagcagcgc gacattccag ccgacgccag aggccctgga 30721 gctgctggcc gacgctagga atgcggcgat catctacatc agcgggcgca ccagcacact 30781 acggcccagc gcggccgatg aggcccttgc actacgccgt gcgctctcgg ccaggtcgta 30841 cttggtggcg cgcggcgtct cgccgctcaa gatcatggtg aacttcgcat cggccgccga 30901 tttcgtggca gacaactcga cggccgaggg ccggcgcgag aaccagcgcg tggacattga 30961 ggtggtctac atccccacct actgagcgat ccggcatcgc cattcctggc ggtgctgcag 31021 gtcgctccag cagcttcgca tcgtcggctc tgacgatgca ggcccggccg gcttcccttg 31081 acagcatcgc catttctgac gatgctggcc aagtcccgat ttactccagg aagaaggcca 31141 tgagataccc cggcggcaag ggcggtgccg gcgtctacca gacgatcatc aacaacatcc 31201 cgcctcacga cacgtacatc gaaacgcacc tgggcggcgg caacatcctg gagcgcaagc 31261 ggcccgctgc ccgcagcgtc ggcatcgacg ttgatcccga ggtgatcgag gtctggcagc 31321 agctcgacgt gcccggcctg gagctgcacc acggcgacgc cgtggcctgg ctggagtccc 31381 accagttcac cggctccgag ttcgtctacg ccgatccgcc ctacgtgatg gacagccggc 31441 gcggcggcaa gctataccgc cacgaatacg acgacgccga ccacgtgcgg ctgctcgacg 31501 tgctggccgg cttgccgtgc gcggtgatgg tgtcgggcta cagctcaacg atctatgaca 31561 gctctccctt ggcgtcatgg agaaccatcg acttcaacgc gatgacgcgc ggcggcatcg 31621 ctatcgaacg gctgtggatg aactaccccg agccggccga gtaggtcacg cctgcgcctg 31681 gttgtgcagc gcccatacgc gcttgacctg tcgttttcag aagacggctg cactgaacgt 31741 cagaagccga ctgcactata gcagcggagg ggttggatcc atcaggcaac gacgggctgc 31801 tgccggccat cagcggacgc agggaggact ttccgcaacc ggccgttcga tgcggcaccg 31861 atggccttcg cgcaggggta gtgaatccgc caggattgac ttgcgctgcc ctacctctca 31921 ctagtgaggg gcggcagcgc atcaagcggt gagcgcactc cggcaccgcc aactttcagc 31981 acatgcgtgt aaatcatcgt cgtagagacg tcggaatggc cgagcagatc ctgcacggtt 32041 cgaatgtcgt aaccgctgcg gagcaaggcc gtcgcgaacg agtggcggag ggtgtgcggt 32101 gtggcgggct tcgtgatgcc tgcttgttct acggcacgtt tgaaggcgcg ctgaaaggtc 32161 tggtcataca tgtgatggcg acgcacgaca ccgctccgtg gatcggtcga atgcgtgtgc 32221 tgcgcaaaaa cccagaacca cggccaggaa tgcccggcgc gcggatactt ccgctcaagg 32281 gcgtcgggaa gcgcaacgcc gctgcggccc tcggcctggt ccttcagcca ccatgcccgt 32341 gcacgcgaca gctgctcgcg caggctgggt gccaagctct cgggtaacat caaggcccga 32401 tccttggagc ccttgccctc ccgcacgatg atcgtgccgt gatcgaaatc cagatccttg 32461 acccgcagtt gcaaaccctc actgatccgc atgcccgttc catacagaag ctgggcgaac 32521 aaacgatgct cgccttccag aaaaccgagg atgcgaacca cttcatccgg ggtcagcacc 32581 accggcaagc gccgcgacgg ccgaggtctt ccgatctcct gaagccaggg cagatccgtg 32641 cacagcacct tgccgtagaa gaacagcaag gccgccaatg cctgacgatg cgtggagacc 32701 gaaaccttgc gctcgttcgc cagccaggac agaaatgcct cgacttcgct gctgcccaag 32761 gttgccgggt gacgcacacc gtggaaacgg atgaaggcac gaacccagtt gacataagcc 32821 tgttcggttc gtaaactgta atgcaagtag cgtatgcgct cacgcaactg gtccagaacc 32881 ttgaccgaac gcagcggtgg taacggcgca gtggcggttt tcatggcttg ttatgactgt 32941 ttttttgtac agtctatgcc tcgggcatcc aagcagcaag cgcgttacgc cgtgggtcga 33001 tgtttgatgt tatggagcag caacgatgtt acgcagcagg gcagtcgccc taaaacaaag 33061 ttgggcttca ccgacgcagc gttgtcgggc tagcaagcat ctcaagaaat tcacaagaaa 33121 ggtcagatat ggaccaacac aacaatggag tcagtactct agttgctggc cagtttgcgc 33181 tcccatcgca cgccacgttt ggcctgggag atcgcgtgcg caagaaatct ggcgccgctt 33241 ggcagggtca agttgtcggg tggtactgca caaaactgac ccctgaaggc tatgccgtcg 33301 agtccgagtc tcaccccggt tcagtacaga tttatcctgt ggctgcgctt gaacgcgtgg 33361 cctgaattca cggttgagtg caccgctcag cgctcaagcc gtgcagtacc gcccacagcc 33421 caactggtcg ctccagcgga cggcttcgcc gcccgctgag ctagagcgtt agtaccactg 33481 aaaccctcct ttatttcgcc catgtttatt caaacggcat tcagtttctc aaacgctgtg 33541 cagcgctggg tttgccgttt ctctgggctt cgcctggtgg cgttacgctg gtttgtggtc 33601 tttttggcct ctggcccttg tgtagcaagc gcgagcagct atttttttcg tagtgctgtg 33661 ccgcctcggt ggcaccgtgc cttttcgcag ttagcgcccg tcgccaagtt acggttatcc 33721 gttttggctt ctggctctaa catttcggtc aagccgaccc gcattctgcg gtcggcttac 33781 ctcgcccgtt agatgcacta agcacataat tgctcacagc caaactatca ggtcaagtct 33841 gcttttatta tttttaagcg tgcataataa gccctacaca aattgggaga tatatcatga 33901 aaggctggct ttttcttgtt atcgcaatag ttggcgaagt aatcgcaaca tccgcattaa 33961 aatctagcga gggctttact aagcttgccc cttccgccgt tgtcataatc ggttatggca 34021 tcgcatttta ttttctttct ctggttctga aatccatccc tgtcggtgtt gcttatgcag 34081 tctggtcggg actcggcgtc gtcataatta cagccattgc ctggttgctt catgggcaaa 34141 agcttgatgc gtggggcttt gtaggtatgg ggctcatagt tagtggtgta gtagttttaa 34201 acttgctttc caaagcaagt gcccactaat aaactcagtc atctaacaag tcgttgcagc 34261 accgctccag cacttcgtgc ctgcgctgga cagtttttaa gtcgcggctt tatggttttg 34321 ctgcgcaaaa gtattccata aaatcacaac ttaaaaactg ccgctgaact cggcgttgaa 34381 cgacagcttt cccaaaagct ctacggctgc tctgggtcga caccggtaat cggatcgttg 34441 ccgcactgaa cagcgccccg ttccaggtcg cctccattta tgcggctgaa ccgagggaga 34501 gcagctttac gccgtctggc cgcagttcgc ccttgggcga cacgtgccgg tagagcgtct 34561 gccgggtaat cccgagttct tcgcagagat cgcccacctt ggtttccggt tgccccatgc 34621 tggccatcgc caggcgtagc ttggcggcgg tcatcttgaa ggggcgcccc cctttcctgc 34681 cgcgagcgcg cgccgagata agtccagcga ctgttcgctc ggaaatcaac tcacgctcga 34741 actcggccag cgcggcaaaa ataccgaaca caagcttgcc ggcggcagtc gtcgtgtcga 34801 ccgccgcacc gtgaccggtc aggaccttca ggcccacgct acgcgcagtt aggtcgtgca 34861 cggtgttgat caggtggcgc agatcacggc caagccgatc gagcttccac acgatcagcg 34921 tgtccccttc acgaagcgcc ttcaggcaag cagccaaccc tgggcgatca tcgcgcctgc 34981 ccgaggccag atcctcgtaa aggtgcgcaa ggctcacacc agcggcgatg agcgcatcgc 35041 gttgcaaatt ggtggactgg gatccgtccg ccttcgatac ccgcatgtag ccgatcagca 35101 ccttttcacc cgtcacgtat acgttcgatt atgtgacagt gtgagccgga aagctctatc 35161 cgtcaaaatt tgtcacttaa cccgtcattt tgtttaagac atgcaaaggg tgcatcaggc 35221 aggtaatgtg acagaaattc cggcgggatg ccttccttca cgaaggtggc gcgcaaccgt 35281 tccaaggaag cgggatcgcg ccgaccatag gaagccaacg cgaacagcga gcgtgccgtc 35341 tcggggttgt gtcgcgcttc aatgatggcc tcgtcgatgg cctggactgc acgctgccag 35401 tgattgatgg gctcgggctt cggcgctttc gtcggcaggc cactggtgaa cccggtttgg 35461 ggctcggacc agaatagctt tgcctgctcg cctggcgggc tgatgtccct cacctcaatc 35521 aagctgattg ccgttgccgc cgcctccagc atctgtaacc gtactatcgg attcagggtt 35581 tcatacggtc gccacagact ttgcccagca cgcagcggat gcccgcagcc ttcccagact 35641 tggcggggat accccgcgca ggttccgcac gcggaaagcg gggtgttcag ctcatcgagc 35701 agcgtgcgaa gaagtcgaaa ccacaatccg gcgtggatgc gtcggcgcgg cagctccacg 35761 tgaccggttg tcagtgcctg ccaggtacgc tggtccatcg ccgcaatcgc gtcgctggcg 35821 gtgcgcggtt cggcgtcggc gttctcccaa ccgagaaacc gccctggcac gccccaatag 35881 gattccagcc agcagccatg cagcgggcag ctcagcatca ggggcagctt ccacgcgagc 35941 agtacggctt ggttctccgg atcgctcagg cagagcggac aggcgcggtt tatcggctgg 36001 ctgggcagcc aggcacgcca gctcgtgatg gatcgcgtct tacggcggag tcttggcagc 36061 aacaccgaga gctgaaacgc ataggtttcc aaggcgtctg gaatctggtc atcaaggctg 36121 tccagtagcc aaggcaccca tccggcgaaa ctcatacagc gcagccggtc cagctcgatg 36181 ccgctccgct gggaaagcaa cgccagcagc gagagtggtg gcgcggtgtc caggtcatcg 36241 acctggccgt gaccaagatc gtgctccagc aggtcgggct cctccatgtg atagcaaagg 36301 gccacgcggt tgagccatga ggacagcgcc tcgccttctt tcggggcggg atgcagcggc 36361 cagcgcggcg caggcttcac atcagttccc gctcgaattg ccgccgccgc tcgctgggtc 36421 cggtgtaaac ggccatgctg agtgtgcgat ggttgatcgc ttcctcgccg ctctccacgg 36481 cgacgatggc cgccgccatc agcaagtgcg ccagttcccc tatggtgccc tcgctgcgtg 36541 tgagcaggta gcgagccatg tccagcgtgg caattgggga aggccggcgc agcgggagcg 36601 aagcggcgaa gctggccagc agtgagcagc aatcgtcgtt ggcctcccat accggcagca 36661 tcatcggctc gaagcgattt tccaactggt catcggagcg gatggctagg taggcgtcgc 36721 gcgtgcctac cccaaccaac gggatgcgca gttcgttgcc gaggaagcgc agcaggttga 36781 ggaattcccg gcggttgacg ctgttgccgg ccagcacgtt gtgcagctcg tcgatcacca 36841 gcatgcgcac gccgaccttg cgcagcagtg ccagagccag ttgctccatt tccggcaacc 36901 gtgggcgtgg gcgcagcggc gcgcccatcg cggcgagcag cgcgacgtag aagcggatca 36961 cggacggctc ggacggcatc tgcacgacca acaccgggat gtgctcctgg tcggcgtcgg 37021 agctggccgg gtgggtgcgg cggaacttct cgacgatcat cgacttgcca ttgttggtcg 37081 ggccaaccag cagcaggttg ggcatgcgtt gcttgtttgg ccacgcataa agggcttcca 37141 gccggttcag cgcctcgact gcgcgcggat agccgatcca gcggtcggcg cgaaggcgct 37201 ggatgcgctc gtccgccgga agacgggcca agccctgggc cgccggcagc aggtgggaca 37261 ggtcgatgat gggatattcg tccacggcta ccactcctca atctggtcga acggtttggc 37321 gggtggcaag ttgtctgcct gcgggtcggc aatatccgta tccggcggaa cgggcttgtc 37381 cggccgagct gatgtcttga ggtgctggcg gcgatccgcg tcacgccgcg ccttgcgtgt 37441 ggccttctgc gcgctggtca caatctcacg catctggccg atcatgcgga acagcgccga 37501 ctcatccacc tgttcgcgcc cttgctgccg cagtttcgcc agcgcctgcc gttgttccca 37561 gagggtgaca gccggatgcg acaaggtacg gtagggaatt tccaggtaat gctgtccctc 37621 cggttccagg acccagatac ggctgatgtc gcgcggatcg cgccggatca gaaaggacgg 37681 ccagcgttca cgccgcgcaa tccacggctt gagcgcatcg gcgtagtagt ggatgtggtc 37741 gatgacaaag ccggtgcggg tcagcgtgcg ccggaggatc ggcagaaaat cgaccaggaa 37801 cgaagtagcg cgtgtgacga cggccggtac gccgacacgc gccacggcct cggcccagcg 37861 cgcggccggc ggttggagca ggccgttgtg caccgaaccg tggtaggtgc cgaccgccaa 37921 tgtgagccag cgctctagct cgcgcagcgt cagggcggcc ttgttttcgg aatcgtagtc 37981 gccgcgctgg tcagggttgg agaaggtcgt tcccggcagt tcgtcgtgaa tcatctgcat 38041 cgccgtgccg atgatccgtt ccacgatgcc gccatagtgc ggctgtccca gcgggcgata 38101 gtccagccgg atgccatgct gctcgcaacc ccggcgcagg gcctcgctct tgaactcggc 38161 cgcgttgtct aggtagagca gcaagggctt gccgctcatc tgccaatcca tttccacgtt 38221 cagtccttcc agccaagggc gcttgtcgca ggcgacatgc acgaggcaca ggccaaccga 38281 aacggcagac ggcgcttcca gcgtgacgac catgccgagc acgcagcggg tgaacacgtc 38341 gatggcgagg gtcaggtacg ggcggccaat aggttgccgg tcgcggtcat cgaccacgat 38401 caggtcgatg accgtatggt ctatctgcac ctgctccagc ggcgcggtca cggcaggagg 38461 ctcgccgccc acaccttgta ggtcacgagc ggcatcctgg ccttcccgcc ggcggatgac 38521 cttgcgcggg tcaaggctag cgatccgtaa ggccacggta ttgcgcgccg gcactcgcag 38581 tttttgagcc ttgcacacct gagtgacttc gcggtgaaag gccgctaggc tgcgcttctg 38641 cttggtcagg aaccgctttt gcagtagctc gtggatgacg cgctcgaccg gttccggcaa 38701 gcgcccctta cctttacctc caccggactg gccgggcacc agatccgtca cgaggccgct 38761 gccttgccgg gcacgccgga tcagaacgta tacctggcgc cgagacaagc ccagcgcctg 38821 agccgccata tcggccgctt cgtgcccgac cgtctccgac tgcgccaacg gactgatgat 38881 ctccgcacga cggcgcgcac gctcccaagc ctcatcaggc agagtggcca cgccttgttc 38941 tggaatccgt ggggtgtccg tcgccatgct cacctcgctt tggtgcacac gagtattgag 39001 catagtcgag attggtgcag atcacttctg atattgaact gtcaggagct ggctgcacaa 39061 cagccattac gcccaatcaa ctggtgcagt cgtcttctga aaatgacatc ttggccgggt 39121 cgttattggc gggtctaaat ggccgctccg tggatctcat cgccagaaat ggcgatgcga 39181 gatccagggc agggcggccg ccatcgtcag acctggcgat ggtcgacgcc ggcgcgcatc 39241 gtcggatgtg gcgatgcgag ctcgaggtcg gtggccaccg ccggcgacct ggtgccatcg 39301 tcggcaatgg cgatgctgca gctcgacgtg cgcggcctgg tcgtctcggc atcgtcggat 39361 gcggcgatgc tcgagcgagg cgaaaaaaaa ccgcctcggg gtgtccgagg cggcaagtct 39421 gcatgcggtt cagggaggaa gaaaccgcgc cggcgatcag ggaggaaaac cgcgcggcct 39481 gatgtgcagc tcggccactt tagccggatt tttcgactta tccgatgcga gcggcccgcc 39541 gtgggcgctg ctcgatctgc tgttgctttt tctcgacgtg cttctgctcc tggtgctgct 39601 gctcgtcgcg ctgcacctgg ctgatggccg cgccgatctg ccgcttcacg ccctcgatgc 39661 ccagctcgct cttgtgcgcc aagtcgttga agtcggtgtg ctgcttcatc gtggacagcg 39721 ccgcgatctg cgcgccgctc aacatcgacg ccttgagctt ggccgcctcg tcgccggcca 39781 gctcgacctt gccggcggcg gcgtcggcaa ggcgctgctc ggcgcgcagg tgggtcttga 39841 agctgtcggg cgtgatggcg ggcaagtcgc gcgggtaggt gttctcggcc ggcgcgaaga 39901 tcgggaagat cgccttgccg cccacggcct gggcggccgc ctcggccttc tcccggccgg 39961 ggttgttgcc gtgggtcatg accaggtgcc ggtcgtcgtc gccggcgatg atgaccggct 40021 tgtccgggaa cttggcgtgc agcgccttcg ccacggcctc aaggttgccg ctgtcgaagg 40081 cggcgaccgt ggcgtggccc acggcctcgg ccacctgggc cgccgtggcg tagccctccg 40141 agatcaccag cgccggcgcg gccgccaggg cgtccatgcc gccgaccggg tggaagcatc 40201 cttccttctt cgagtccttg gcgaaccgct tagtgccgtc ctcctggatg tattgcatcg 40261 tccattgctt gccctctgcg tcgaaggccg ggatgtaggt cttctggcct tcgcggtcgg 40321 tcatcacgcc ggcctgcgcc tggatgcctt tggcttgcag gtagggcgtc ggctgctcga 40381 tgggcacgag gtcggccatc tgccgaccga cgcgctgcgc ggtggcctcc tgggccttgt 40441 cctgctcgac ggctcgctgt gccagcttct cggccgcctc ggcctggagc ttggccttct 40501 cctggtcgct caaggcgtag cccttgctct tccaggtaat gtccgtgccg gtcttgttgt 40561 tgatgatccg cccggccggg tgcccgtcca ggtggcccac gtagaagcca tcgagcgcgc 40621 ccttcttgcc gccctcgacc ggcacgcggt gccgcttgcc atccatgatc gggtgatcgc 40681 cctgggcgtt gctgccggtg aacaggccgg cgctgcgcat ggcctcggcg aactcttccc 40741 ttggcgtcat cgctggccct tgctgggcct gcacgttctc gggcttccag cgttcgagct 40801 tcgccgcgtc ggcgcgcggg ccgacatacc aggacttcgc ggccttgtcc caaagcgcgc 40861 cggcggcctt ggccgcgttg cgctgctcgt agggcacggc caggtactgg cgggcctgct 40921 gggcctgctg cgcgggcttc tgcgcctcgc cctgggcttc gggtgccggc tgggccgaac 40981 gcggctctac ggccgctgta gcggctccct gcgcccattt ggcgaaggga gcggcatcgg 41041 tgcccggcgg cacgtaccag gactgttgct gccgatccca acgcgccccg aggctcttgg 41101 cctcgtcctt ctccttgtac ggcacgttga tgtactgccg ttcgggcttc tcggcctgcg 41161 gctgcgcctg ctgccgatcg cgttcctggc gctccagctc ggccgcgcgg cgctgcgcgt 41221 cgctgtcgtt gagcatggcc gacgcctcgg cggtcttgcg tgcctcttta gcggctgaaa 41281 tgtcctcttc ggtcgcgttg gggtcgcgcc gtacacgctc ttcctgcacg cgggccagct 41341 tggcggcgcg ctcgtgctgg ttgtcggtgc ccagcgcatc gaccaggtgc aggcgctcgg 41401 ccagagcctc ggcctggccc tcggtgcggg tgccggcgac gaaggcaaag gcgtcctcgc 41461 cgaactgcgc atcggccttg cgcgcgtaga cctggaacgc ctgcggctcg atgccggcct 41521 gggcggcatc gacggtctgg ccgtcctgct cggccacgcc gacgatgcgc agctctccgc 41581 tccagtcggg cggcagctca acgccaaggt gttgacgggt cgcgtcggcg aacgcctggc 41641 cgtcgatctc gccggcggcg agctgccggc gcgcggcggc ggcctgctcg atgccctgca 41701 ccgcgtcggc aggatgggcg gccagcaggg cggccgcctg gtcgatggtc ggtggggtca 41761 tgttcgcctc ctggtctgcg acggccgctt gctgctgggt cagcgccggc agggccatca 41821 actggtcggg cgcgtagttg ttcagctcgt ccaggctgcg aacctggtgg ggttcaccgt 41881 cctggtcgtg gaacgcaaag atgcgctggc cgtcgctcca cctggcttcg gcgtcgatgc 41941 tcgacacgat ctgttcgccg tgctgctgga gctgctgcgc gaggtggagc tgttcggcca 42001 tgttggcgaa ctcttgcgcc aagcccttgc gctccaggta ggcgttgtcg gtgtcggtgt 42061 ggctcgggtc gatgccgaac accggcgaca gccggtcatg cgcgaccgcg tagaactgct 42121 cgggatcggt gccggtgatg ctgcccacgg tttcgaggcc acggctgcgc aaggcgtctt 42181 ccagggtgtc gccctggaat gcctggtagt ggctgaaaga cacgtccggg ttgtccagga 42241 cttcggcaat gtccacggcc agggcctggg ccacggcttc gtcctgggcc tggctctgct 42301 gctggtcttg ctcctgaacc tgcttctgct cgaaggccag cacgtagtcg tgaatcttct 42361 cggcatcggc ggccgcgcgg aacacctcca gcggctcgtc ttgcagcgcc ttgatccacg 42421 aacccacata ggcggcgtgc tggcccggat cgtggccgat gcccagctcg tcgccgacga 42481 tcatggaagc gatctcggcg cgcagctctt ccttggcgta cccctcgctc ccgaacgggt 42541 gcgccaggtc gcggtcaagg cgcgaagcgt ggcccgtcca gtggcccagc tcgtgcagcg 42601 cggtcgcgta gtagcggtcg gagctgggga actggccgcg ctccggcagg gtgatgctgt 42661 cggtcgaagg gcggtagaac gcccgatcac cggcggcgtg ggtgatcgtc gcgcccgagg 42721 ctttcaggat gtgctcggcg cgctcgacgg cgttccaagt ctgttccttc ttcggctgga 42781 gcggcggcag gccgtcgatc tgctcgccgt tgaacacggt cgcaaagaac acgcgcggcc 42841 gctccagcat gacggtttcc ttgaccggct ggcccttcgc atcgaggacg ggccggccgc 42901 tgtcgtccag cttgtcttgc tcttcgctga acttccagta ttgaaccggc gtgcctttct 42961 cgcccttgcg aacctgcgcg cccacggcgg cggcctgctt gtaggtcatc cagcgcgcat 43021 cgctgcggcc ctgggccatc aggtggatgg cgttgatccc tttgtaccgc ttgccggtgg 43081 tcgggttcat cggcaggtag gcgttgggtt cgcccggctc ccacggcttt tgccacggtg 43141 cggtgccggc cttgagctgc tcgatcagct tttcggccac gacttcgtga aacggcttct 43201 tcggctccat gttctcgtcc cttcggaata gctcgttgaa ctgagggaag ttctgctgtg 43261 tccgggaacg gtcgcgcagg ccctgggcga ccatgcacac gatgttgtgc aggtcgtcgg 43321 cctgcatggg ccgcacgcgg gcgatgcagg tttccgtgaa tgactgttgg ccgcgctgct 43381 gcacctggtc ggcgacctgg tgctggctcg gctcgatgcc ctcgcagtgc agggcaaaca 43441 cttcctcggc gcgcacgtcc agggactggc cggcatagcg ccggttcacg tcatcccata 43501 gcggcttgag ggtgggttcg ttgcgggcgg ccgccaggcc gtccagcaag gcgcgcttct 43561 cgcccggcgc gaaggtgttg gccccgtagt ggcctagcac ctcgtgccgc agcgtcatca 43621 gtaggtcgct ggcgctctcg acgttctgca agggcacgtc cacgcggcca cggtaagcgc 43681 ggccggcgtg cagcgtctcc ttgggcacgt agccgccctt catgtcggcc ggcacctcgg 43741 ccgctcgcgg cccgtacagc tcggccgcgt cctcgcggaa cttgtaggcc agctccagcg 43801 cgccggggta gtcgcggacg aaagcccgcg tcaccccttg cgcctcggct ttcgtgatcg 43861 gcatgggtca gccctccgac gccttgcgcg cggcggcctg ggcaaccgtc tcgccgggcc 43921 gcaggtcgta cagctcgcgg gcgttcgtgg tggtgatgaa cggcgggatg tcggcgctcg 43981 ggccttcgtc gtccaggaat gccggctcca gcgcgccatc gacttccacc aggtcgtcgc 44041 cgctcgcggc ggcgtcctgc tcggacagcg cgtcctccac gaacgcgccc acgcgctcgg 44101 cttcgtcggg gtcgaactcg acctggaagc cgggcgtcag cgcgtcggcc atcttctcgc 44161 gcacggcctc gcggccggcg gcgtcgtcgt caaccggcgg caggacggcc agcggctcgt 44221 cgtgggcggc ggtgttggtg gtggtttgct cgttcatggt cgatctcctt cgctgtggtc 44281 attcggatgc ctggccgttg cggcccttgc tgtagtcggg ccgacccttg aggtcggggt 44341 aggtctgctt gcatgtgggg aagttgctgc aaccccacca gaattgcccc ttcttcttgc 44401 tcggccggcg cgacaagccg ctgccgcagg ccatgcactt gtgaagggat gacaccggcg 44461 cggcttcctt gccgccggcg atggtcacgg ctccgctgtt ggccttcgcc acctggtcgc 44521 ggatgaacgt ctcttgcttc gtgatgaagg cgtccagggc ggccgtgccc tgctcgacgc 44581 ctttcagcat ccgctcgtag agcgcggtca gcaccgggct tttcacaacc tcgggcagcg 44641 cgtcgatgac gctgcggccg agggtcgtgc tgatgatctg cttgcctttg acggccagga 44701 actcgcgccg cttcaactcg gaaatgatcg acgcgcgggt ggccgacgtg ccgatgccgt 44761 cgccctcgcg cagcatcttc ttgtgctcgg catcgctgac gaacttgtgg atgttctcca 44821 tcgcgcggat cagcgtgccc tcggtaaagc gcgctggcgg cttcgtcttg gcgtccttgc 44881 gggtggcgtc cgtgcaggtc acggcgtcgc cctgggccat cgacggcagg gcctgcgtgc 44941 cgctgtcgtc gtcctcgtcc ttctcgcctt cctcgtcggc ctggctgtac acgtcacgcc 45001 agccgttgcg cgtgactacc ttgccgctcg cggcgaagtt ctcgcccgcg aatctcgaac 45061 gcccacggtg gtctgcatgt actcgtgcag cgggtagaac tgcgccaggt aggcgcgcac 45121 gatcaggtcg tagatgttgc gctcgcgctc gctgagggcg gccttgctgc ccttctgcat 45181 ggtcggcacg atgccgtggt gcgcggtgat cttcgagtcg tcccacgtct tggacttgat 45241 acgcggatcg gcaccatcga ccaggccggc cagttggggt tgacgtgctt gatcgcctcc 45301 agcacgcgcg gcgcgtcggc gtgctgcgac tccggcaggt aggcgcagtc ggtgcgcggg 45361 tacaagtcag cttgtgcgtc tcgtaaagcg cctggcaggt gttcagcacg tcctcggcgc 45421 tgtagccgaa cttggccgag gccagtgccg tgatgtcgga cagggcgaag gccagcggct 45481 ggttctgctt cttggcctcc tgtttgtacg cggcgatggt gcccggctgg cccttgacgg 45541 cggccaccag ggcgtcggcg acggcggtat cgacaaggcg gccttcgctg tacaggccgg 45601 cttgatcctc ctttgccttc catgcggcgg cgaagctgcc gccggcgtgc tgcaccaccg 45661 cccggatggt gtggtacggc acggccttga atgcctcgat ctcgcggtcg cgggcgacca 45721 cgagggccag cgtcggcgtc tgcacgcggc ccacggtcag cagggcgcgc gagccgccgc 45781 gctgcgcgcg cagcgtgtac gcgcggctga ggttcatgcc gatcagccag tcggcgcgct 45841 gccgcccgcg tgcagcgtcg gcccagcctg cataggtggt gttctccttc aacgcggcca 45901 ggccgcgctt gacggaaacg gagtcctgcg cgctcaccca aaagcggcgc accggcttgc 45961 tgttgcggaa gtgctccagc acttcgtcaa ccagcaactg gccttcgcgg tcggggtcgc 46021 cggcgttgac gatctccttg gcctccttga gcagcttgcc gatcacggcg agctgcttct 46081 tcgcgtcgtc cttgggcttg agaatccagc tctcggggat gatgggcagc tcatcgacgc 46141 gccagacctt cttgccggac tggccgcgcg gcacgtcatc gggcgtgtac tcgtcggggt 46201 cggcctgttc gagcatgtgc ccgaagcacc aggtcacttt gtcggtgccg cactcgatga 46261 agccgtcgcc cttgccggtc gcgcccagct cgccggcgat ggccttggcg acggacggct 46321 tttctgcgat gaaaaggcgc atggtgtgtc tccctaccag gtgatgaccg gacggatcac 46381 ggtcttgatt tgcgaacgat tgatcgggcc gaagtagcgg ccgtcgaagg atgtggcgct 46441 cacgtccgac ataagcagca cctcggaatt gccgagcgtg tagctgttgg actgatagcg 46501 cggcagcggc cgaccggcct tgtcggcctt gatcggcgcg ctgaggggca gcagctcgcc 46561 gttgacgcgc acgccgtcat cggcgacggc gacggcatcg tctttagcgg ctaaaacgcg 46621 cttcatcatg tagccgtagc cgccctggca gaagccggcc ccgatgtagc ccctctcctt 46681 ggcgtcatcg aacacgccga gctgcggcgg gcagaagagg acgtaggccc ccttctccac 46741 cggcgcgctg ctcgtccagt acaggccgac cggaatgctc ttggtggtgt tcacgcgggc 46801 accggcggca tagccgccgg cggccagcag cagggcggcc acgcccgcga tgacgacgcc 46861 tgccgcgata cgtttcagga tgcggctcat atcgtgatgc cctccccttc cgtgtcggcc 46921 tgtgcgacgg cgcgcaggcg gtcgctgacc ttgggcgcag ggatcgcggc gcgtgccgag 46981 aacactgggt ctttgaagta caggggttgc ttgccgtaga tcgccgggta gcccgcgacg 47041 tagatcacca tgtcgccggc ttcttcgatc tcgccctggg cgttcttctt tggccccggc 47101 atgcgcaggc attcgtcggg cgtcagcaag ggccgctgca cttcctggta agtgcgcgac 47161 acctggccca gcatcgccgc cgtgcggcgg ccgctggtcg tgatctgctc cttcaccacg 47221 gtggtctgcc cggtgaggcg ggacaggtgt tcggccgtct cgacgcggtt gggcgggtag 47281 gcgttctgca cgtggcagtt cgacgtgatg ctttcgtcgt ggccgtagcc cgtctcgcgg 47341 ctcttgagct ggttaatgtc ctggcagatg aggtagcact tgatgccgta gccggccacg 47401 aaggccagcg actcttgcat gatctccagc ttcccgaggc tcgggaactc gtccagcatc 47461 atcaagagcc ggtgcttgta gtgcgccacc ggccggccgc cctcgaagtc catcttgtcg 47521 gccagcaggc gcacgatcat gttcaccatg acgcgcacca gcggccgcag gcgggcctta 47581 tcgttgggct gggtgacgat gtagaggctt accgggtcgt cctcgtgcat caactgcttg 47641 atgcggaagt ccgaccggct gacgttgcgg gccaccacgg ggtcgcggta cagggccagg 47701 tacgacttgg ccgtggacag caccgatccg gcttcttcct cgggccgatc catcatgtcg 47761 cgggccgccg agccgatggc gtgatggttc tggccgtcta cgtgcccgta ggtcgccatt 47821 tccatccaaa gctcgccaat gtcccggttc gggtcggcca gcatcgcatc gacggacggc 47881 agcgtggcgg tgccgccatc gtccttggcc ttgtacagcg cgtgcaggat cacgccgacc 47941 aggagcgcga aggcggtctt ctgccagtgc gagtccaggc ccttgccgtc cgggtcaacg 48001 atcagcgtgg caaggttctg cacgtcaccc acctcgtatt cggtgccgag gcggatttcg 48061 tccagcggat tccagcagac gccgcccgag gtgctggccg gctcgaagcg cagcaccttg 48121 ttcttggcgt gcttctgccg ccagccggcg gtcaaggccc acaactcgcc cttcaagtcg 48181 gtgatgacgc tgctcgcgcc ccacgacagc agcgtgggca ccaccaggcc gacgcccttg 48241 cccgagcgcg tgggcgcgta ggtcagcacg tgctcggggc cgctgtgccg caggtagaag 48301 aaattgccgt ccttgtcctg ccagccgccc acgtacacgc cggtagccgt gggtgcggcc 48361 ttgccggtga cgatctccag gacgttgcgc tcgcgtggca gcaggccggc cgcctgaatg 48421 tccttcttct cggcccagcg ggccgagccg tgcaggtact cgttcgcctt cgagctgttg 48481 gacgtgacga ccttcgccac ggccacgccc agcaggccca cggtcgaaac cagcatcccc 48541 atgctgccgg ccttcatgat ctcgtccggg tactggctgt accacttgta cgtccagtgc 48601 aggatcgacc agggcgcgta cacgtggccc acgttggggc cgagggtcgc gtgataggcg 48661 aacgtgtggg cgaagaactg cgtcgcggcc tggaggccgc cgaccatcga ggccgcgccc 48721 agcaccggca gcagcttgct cggcttcggt ttggcggttc ggacttgcgg ccctaccgcg 48781 ttgttcatct tgatcttcat ctactccttc ctttcgacgt tttgatggag cctttcgcgg 48841 tgatcgagac ggcatcgcga ccgaccgcga tgcgcgtcaa gcgccgggcc gtggcctggt 48901 cgatgggcat aaccatgacc tcatcacctc gtttcaagag ggccagcgcc tggccctcga 48961 tagtcctggt gccctggaac gtgagcgcac catcaccggc agtatatcgg gaatgcttcg 49021 gtatatcgaa accttttagg cgctttgcct cgcgttcggc gatgtacttg tcggcggcgg 49081 cgacgcccgg cggcgtctgg cctactcctg ttcctggccg agaaattccc cgtcgcagtg 49141 cgtgatctgg ttgggttcct tgctgctcca cgtgacgagg aacatcacgc ggcaatagca 49201 cttcacttcc gccggcgatg cgaaccacac cgagttcgga cagtgctcgc aaacggtgct 49261 ggctttgggg cggcggtttt cttccaaggc gtccaacgtc gggcttccgg tggacggtgg 49321 cggcgtgaag gccggcgtcg gcgcggtcgc ctcggccggc ggctggccgg ccgtcgcctg 49381 ctcgggcgac ggctgcggct ccggtagcgt gctggtcggc agcgggccgc tgtccagggc 49441 cgccagcgcc gcgtccagtt cgtcctcgat gctctggtct ttcggttcgc tcatgggtgt 49501 tctccttgtt caaaagcgcc tgccgccggc tctcaagagc cggatcggtg aaggtgatgg 49561 gtagctggga atcgacggcg gcgcggatca tctgcgcctt gaactccacc gtgccgttga 49621 cggtgatgcg gttgccgtag cgttgcatcg ccaggcgcag ggcttcttgc agcccttcgc 49681 gcgtggcctc gcgggagact tgcaggcggt caccgtcatc gcgcacggcg ctcatgccgg 49741 cgcggaagat gatcgtcccc ttcttcgtga tgttgtccac cgccggcgcg tggccgggct 49801 tcgcctggcc ctcgccccgg atggtgttgc ccttgaggcc ctgggccgcc tcgcgggcgc 49861 gcagggcggc cagggcgtcg gcgccgccgt gctgcgcctc cttcttgagc cagtcggccc 49921 acgtgcgccg gctgtgctcg gcgtagaggg ccgtgcgctc ctgctggaac tgcttgttga 49981 tcgcctggat ttcgctgcgc agggccttgc tcgcctgggc gtacagcagc ttcttgttcg 50041 cgcggccctc gccgaccacc ttaatcgtgg cgcggcgcag gcggttcgac ctcttggccg 50101 cctcgatcag ccgatccttg cgatgccggg cgcgctccag ggcctgggcg cgcgccgtgg 50161 tcaagctctg ctgctcggcc ttgtacttcg cgtacagctc cacggtgttg acgcgaaggc 50221 ggatggggtc tttgcggtac tgccgcttcg cggtggtttg cgcctgccgt tcgggcgaag 50281 cctcgaacgg gccaagccgc gcctccaggc tcggcttgga aaggtcgcgg gctactgtgc 50341 tcgccttcac catcgttccg tcgccggcct cgaacacgag gccattggcg cggacgcgca 50401 gctccattcc gttgtcgcgc atgacctggt gcagttcctg ccaggactgc gcgcccttga 50461 tctcgtccag gcactcgcgc ttgatccagc cgaccaggct ttcaacgccg gcatgccgct 50521 ccatgtcggc ggcccggccc tccgcgccgc gcttgcgcgg ctcgtggttg tcgcgctcca 50581 ggccgtagtc gcgctccagg gccgtgcaga gttccgccag cgcccggtgc gggtagtacg 50641 gctcgtgcat cgtgtgccgc gtcgggtgaa tcttgttgat ggcgatgtgg atgtgcaggt 50701 tgtcggtgtc gttgtggacg gcactgattc gctgatgctc gccataaccc agcccgacgc 50761 agatgcgttc ctcaatcgcg cgcaaggtgt cggcgctggg ctgctcgccg gcccggaagc 50821 tgacgatcag gtggtaggtc ttgtcgccct tcgcgcgggt gttcgtgtgc tgggtcgcca 50881 gcacctccgt gatggcgtcc tggatggaac cggcttcgca gttcgtcgcc tgcacgtggc 50941 ccagccggtg gtctttgctt tgggcgtcgg tgatgtagtt cgccaggccc gcgaagtcgc 51001 tcttgccaag cgagcgcatc ggcacgtgct tggcgatcat ggccgcccct ccggcttttt 51061 agccgctaaa gaagtcaagg ctcggccctc ggctgaacca cggccttcat gatccggctc 51121 atttcgtcct gggtggcctc gatccggccc agcagggcca ggatggtcgc ctcgccgaac 51181 tggagcgttc gcacgtcatc ggtcagccag agcttgagca ggccgccaag gcggccaagg 51241 tcgccgttga cgcgcaccag ctcgcgcacg tgctggtagt ccatgacgcc cttgatctgg 51301 tagccctggc ccacgtcgcg cagatagcgc gccacgctga cgcccgccct cttggcgttc 51361 gcctcgatct cgtctttctc ttcggggaac accggcaccc gcaggtgctg ccgccgccgg 51421 cggccgtgtt ccttttcgtc gttctccatg cctcgcctcg tctctcatgc cggcggtagc 51481 cggctgcctc gcagagcagg atgacccgtt gagcgccccc ggcgcgaata agggacagtg 51541 aagatagata accggctcgc cggttagcta acttcacaca tcctgcccgc cttacggcgt 51601 taataacacc aaggaaagtc tacaccagcc attacgattt atccgcaact atcgcgctat 51661 caggccgcaa aagcagcaac ggatatagcg aaacccgcca caatggccca taatgccgct 51721 atcgaagcgt gccaatgcac gccgatagcg gactttttgc gtttccgtag cgccgcttag 51781 tagcgttaca tttgcgatga gaggattaga tggacgaaca cgatgccaaa gacctacccc 51841 gaagagctgg ctgaatgggt gaagggacgg gaagccaaga agccgcgcca ggacaagcac 51901 gtggtcgcgt tcctggccgt caagagcgac gttcaagcgg cgctcgatgc gggctatgcg 51961 atgaaaacga tctgggagca catgaaggaa accggccggc tgcgctgtcg gtacgaaacc 52021 ttcacccagc acgtgaagcg gtacatcaag gccgcgccgg tagcttcccc gccgcctccc 52081 gccactcccc cggacagcca gcccaagggc gcgaagcccg agccgaaggc cgccccgccg 52141 gcctcggaat ccaagagtga gccacccaag atcggcggct tcacgtttga tgcgactcca 52201 aagaaagagg atttactgta atggcgaaaa ttcacatggt tctgcaaggc aagggcggcg 52261 tcggcaagtc gatgatcgcg gccaccatcg cgcagtacaa agccggcaag ggacagaagc 52321 cgctttgcat cgacaccgat ccggtgaacg cgacgttcga gggctacaaa gccctcaacg 52381 tgcgccggct caacatcatg gacggcgacg acatcaacac ccggaatttc gacgccctgg 52441 tcgagatgat cgcgtcggcc gagggcgacg tcatcatcga caacggggcc agctcgttcg 52501 tgccgctgtc gcactacctc atcagcaacc aggtgccggc gctgctccag gacatgggcc 52561 acgaactcgt ggtgcatacg gtcgtcaccg gcggccaggc cctggtggac acggtgagcg 52621 gcttcgccca gctcgccagc cagttcccgg ccgaatgcct gttcgtggtc tggctgaacc 52681 cgtattgggg gccaatcgag cacgagggca aggggttcga gcagttgaag gcgtacacgg 52741 ccaacaaggg ccgtgtgtcc gccatcatcc agattccggc gctgaaagag gaaacctacg 52801 gccgcgactt cgccgaaatg ctccaggatc ggcgcacctt cgatgaggcc ctggccgatt 52861 cggcgctcac gatcatgacg cggcagcggc tcaagatcgt gaaaacccag ctcttcgccc 52921 agctcgaaaa cgcggcggtg ctctgatggc ggccgacgac aagatcgagg agctgatacg 52981 ggagatcgcg gccaagcacg gcatcgccgt gggccgcgac gatccgatct tgatcctcca 53041 gaccatcaac atgaagctga tgcaggacag cgcatcggcc cagcaggaaa tcttggacgc 53101 cttcaagtcg gaactggagt ccatcgccca ccgatggggt gatgacgcca agggaaaggc 53161 ggaaaggacg ctcaacgcgg cgttggcggc cagcaaggac gccatgacgc ggggaatgca 53221 ggagggcgcg aaggcggccg ccgaggccgt gcggcgtgag gttgaggcgg tgacggcgca 53281 gctcgtcgcg ccgatccgcg aggcgcggcg cgtcgccatg atgaacatgg tcgcggccgg 53341 catggcggtc gtggccgccg gcctggccct gtgggcctcg ctgtagatgg cgatgcggga 53401 tctcatcgtc agaactggcg atg //